Tdark VPS26B Vacuolar protein sorting-associated protein 26B

Protein Summary

Description

Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5. May be involved in retrograde transport of SORT1 but not of IGF2R. Acts redundantly with VSP26A in SNX-27 mediated endocytic recycling of SLC2A1/GLUT1 (By similarity).

Uniprot Accession IDs

• Q4G0F5
• Q96A55

Gene Name

• VPS26B

Ensembl ID

• ENST00000281187
• ENSP00000281187
• ENSG00000151502
• ENST00000525095
• ENSP00000434162

Symbol

• Pep8b

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.99
histone modification site profile	0.81
co-expressed gene	0.69
transcription factor	0.62
transcription factor binding site profile	0.6

Protein Classes

PANTHER Classes

Protein / Membrane Traffic Protein / Vacuolar Protein Sorting-associated Protein 26b

DTO Classes

Protein / Transporter / Vacuolar Protein Sorting-associated Protein 26b

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.69   (req: < 5)

Gene RIFs: 2   (req: <= 3)

Antibodies: 109   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.69   (req: >= 5)

Gene RIFs: 2   (req: > 3)

Antibodies: 109   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0