Tbio VMP1 Vacuole membrane protein 1

Protein Summary

Description

Stress-induced protein that, when overexpressed, promotes formation of intracellular vacuoles followed by cell death. May be involved in the cytoplasmic vacuolization of acinar cells during the early stage of acute pancreatitis. Plays a role in the initial stages of the autophagic process through its interaction with BECN1 (By similarity). Involved in cell-cell adhesion. Plays an essential role in formation of cell junctions (PubMed:17724469). Required for autophagosome formation (PubMed:30093494). This gene encodes a transmembrane protein that plays a key regulatory role in the process of autophagy. The ectopic overexpression of the encoded protein in cultured cells triggers autophagy even under nutrient-rich conditions. This gene is overexpressed in pancreatitis affected acinar cells where the encoded protein mediates sequestration and degradation of potentially deleterious activated zymogen granules in a process termed, zymophagy. [provided by RefSeq, Jul 2016]

Uniprot Accession IDs

• Q96GC9
• B4DVV9
• Q9H0P4
• Q9P089

Gene Name

• VMP1

Ensembl ID

• ENST00000262291
• ENSP00000262291
• ENSG00000062716

Symbol

• TDC1
• TMEM49
• EPG3
• TANGO5
• TMEM49

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	1
small molecule perturbation	0.96
transcription factor binding site profile	0.9
histone modification site profile	0.84
cell type or tissue	0.8

Protein Classes

PANTHER Classes

Protein / Signaling Molecule / Vacuole Membrane Protein 1

Protein / Receptor / Vacuole Membrane Protein 1

DTO Classes

Protein / Signaling / Vacuole Membrane Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 154.33   (req: < 5)

Gene RIFs: 30   (req: <= 3)

Antibodies: 207   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 154.33   (req: >= 5)

Gene RIFs: 30   (req: > 3)

Antibodies: 207   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0