Tbio VMA21 Vacuolar ATPase assembly integral membrane protein VMA21

Protein Summary

Description

Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum. This gene encodes a chaperone for assembly of lysosomal vacuolar ATPase.[provided by RefSeq, Jul 2012]

Uniprot Accession IDs

• Q3ZAQ7
• A6NKV7
• B3KUA9

Gene Name

• VMA21

Ensembl ID

• ENST00000330374
• ENSP00000333255
• ENSG00000160131
• ENST00000370361
• ENSP00000359386

Symbol

• MEAX
• XMEA
• MEAX
• XMEA

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.94
histone modification site profile	0.88
microRNA	0.75
cellular component	0.73
small molecule perturbation	0.68

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.41   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 70   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3.41   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 70   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0