Property Summary

NCBI Gene PubMed Count 3,705
PubMed Score 17832.74
PubTator Score 20585.28

Knowledge Summary


No data available


  Disease (6)

Disease Target Count
Age related macular degeneration 84
Macular retinal edema 11
Coronary artery disease 240
Atherosclerosis 275
Asthma 349
psoriasis 6685
Acute kidney injury 65
Alzheimer's disease 644
Arthritis, Experimental 39
Brain Neoplasms 23
Bronchitis, Chronic 9
Carcinoma, Pancreatic Ductal 19
Cerebral Hemorrhage 27
Choroidal Neovascularization 1
Colonic Neoplasms 126
Complications of Diabetes Mellitus 5
Congenital Heart Defects 37
Contact Dermatitis 80
Corneal Neovascularization 2
Diabetes Mellitus, Experimental 106
Diabetes Mellitus, Non-Insulin-Dependent 161
Diabetic Nephropathy 37
Endometrial Neoplasms 50
Epilepsy, Temporal Lobe 23
Erectile dysfunction 10
Gastric ulcer 34
Head and Neck Neoplasms 23
Heart Diseases 42
Heart failure 80
Hemangiosarcoma 18
Hypertension, Portal 3
Hypoxia-Ischemia, Brain 5
Inflammation 109
Learning Disorders 27
Liver Cirrhosis 101
Liver Cirrhosis, Experimental 108
Liver Failure 4
Lung diseases 48
Memory Disorders 36
Myeloid Leukemia 19
Myocardial Ischemia 169
Myocardial Reperfusion Injury 34
Neoplasm Metastasis 138
Neoplasm Recurrence, Local 23
Neoplasms, Experimental 33
Osteochondrodysplasias 15
Pathologic Neovascularization 6
Precancerous Conditions 69
Prostatic Neoplasms 471
Proteinuria 63
Retinal Diseases 21
Retinal Vein Occlusion 6
Rhabdomyosarcoma 29
Rheumatoid Arthritis 1170
Squamous cell carcinoma 96
Status Epilepticus 85
Thrombotic Microangiopathies 2
glioblastoma 5572
gliosarcoma 19
non-small cell lung carcinoma 413
osteosarcoma 7933
Disease Target Count Z-score Confidence
Cancer 2346 7.572 3.8
Kuhnt-Junius degeneration 14 6.347 3.2
Retinopathy of prematurity 21 5.762 2.9
Hypertension 293 5.412 2.7
Peripheral vascular disease 90 5.381 2.7
Keratitis 42 5.203 2.6
diabetes mellitus 1663 5.144 2.6
Blindness 84 5.128 2.6
POEMS syndrome 6 4.85 2.4
Ovarian hyperstimulation syndrome 15 4.786 2.4
Retinal detachment 33 4.727 2.4
Cerebrovascular disease 231 4.715 2.4
Endometriosis 535 4.682 2.3
Hemangioma 35 4.668 2.3
Arthritis 248 4.482 2.2
Limb ischemia 12 4.401 2.2
Macular holes 9 4.219 2.1
Endophthalmitis 10 4.194 2.1
Lung disease 136 4.175 2.1
Retinal ischemia 5 4.059 2.0
Heart disease 279 4.03 2.0
Cataract 104 3.958 2.0
Brain edema 26 3.916 2.0
Leukostasis 5 3.872 1.9
Glaucoma 135 3.754 1.9
Hyperglycemia 120 3.753 1.9
Osteonecrosis 25 3.725 1.9
Capillary hemangioma 11 3.681 1.8
Adenoma 165 3.638 1.8
Diarrhea 155 3.596 1.8
Polyneuropathy 30 3.493 1.7
Angioid streaks 5 3.447 1.7
Exanthem 39 3.419 1.7
Hypersensitivity reaction type II disease 235 3.419 1.7
Neurodegenerative disease 383 3.411 1.7
Liver disease 219 3.4 1.7
Neuropathy 210 3.352 1.7
Lymphedema 26 3.347 1.7
Portal hypertension 21 3.322 1.7
Collagen disease 25 3.317 1.7
Myopia 99 3.315 1.7
Coats disease 13 3.312 1.7
Anemia 252 3.22 1.6
Neutropenia 78 3.215 1.6
Rubeosis iridis 4 3.199 1.6
Uveitis 103 3.132 1.6
Peripheral artery disease 8 3.122 1.6
Thrombocytopenia 105 3.106 1.6
Hereditary hemorrhagic telangiectasia 14 3.083 1.5
Inflammatory bowel disease 142 3.072 1.5
Impotence 45 3.005 1.5


  Differential Expression (25)

Disease log2 FC p
glioblastoma 3.500 1.2e-03
osteosarcoma 2.629 4.8e-03
psoriasis -1.300 3.7e-04
gastric cancer -1.600 1.8e-02
hepatocellular carcinoma -1.800 5.3e-06
pancreatic cancer 1.900 1.9e-02
interstitial lung disease -1.600 1.4e-02
posterior fossa group A ependymoma 3.300 2.5e-10
cystic fibrosis 1.438 2.0e-05
atypical teratoid / rhabdoid tumor 2.300 1.4e-04
limb girdle muscular dystrophy 2A -1.447 4.9e-04
acute quadriplegic myopathy -1.094 1.9e-02
tuberculosis and treatment for 3 months -3.100 3.1e-06
primary pancreatic ductal adenocarcinoma 1.890 7.0e-03
intraductal papillary-mucinous neoplasm ... 1.700 1.0e-02
pediatric high grade glioma 2.000 3.2e-04
pancreatic carcinoma -1.400 3.2e-02
lung adenocarcinoma 1.200 3.6e-04
Breast cancer 1.500 3.6e-09
Polycystic Ovary Syndrome -1.303 1.5e-02
mucosa-associated lymphoid tissue lympho... 1.040 9.6e-03
invasive ductal carcinoma 1.200 1.9e-02
ovarian cancer 2.900 2.4e-05
chronic rhinosinusitis -1.350 2.1e-02
dermatomyositis -1.100 3.6e-04
See source...

Protein-protein Interaction (12)

Gene RIF (3803)

27455016 The -1154A or -2578A alleles of the VEGF gene can significantly decrease the risk of EP among Chinese women
27430109 The mean intensity of VEGF staining was statistically significantly higher in melanomas than in benign or dysplastic naevi.
27358128 The action of VEGF and NOS molecules are important mediators of angiogenesis during dental tissue development.
27097314 FGF-2, VEGF-A, and HIV-Tat, may affect the glomerular filtration barrier in HIV+ children through the induction of synergistic changes in Rho-A and Src activity
27067785 The modulatory role of miR-126 on expression of VEGF-A and its tumor suppressive roles were demonstrated for the first time in thyroid cancer
27033444 Novel angiogenic agent COA-Cl induced activation of PGC-1alpha/ERRalpha/VEGF signaling pathway in fibroblasts.
27029009 Suggest that R-Ras regulates angiogenic activities of endothelial cells in part via inhibition of the p38MAPK-HSP27 axis of VEGF signaling.
27001300 VEGF-A effectively stimulateS proliferation, motility, and directed migration of human EA.hy926 cells.
27000664 By simulating the tumor microenvironment, the MV-delivered miR-29a/c significantly suppresses VEGF expression in gastric cancer cells, inhibiting vascular cell growth, metastasis, and tube formation.
26992254 VEGF serum and biliary levels were increased in malignant biliary obstruction patients.
26957843 Rs699947 or rs10434 polymorphism was not associated with the presence of diabetic retinopathy in Egyptian patients.
26930285 overexpressed during later phase of liver regneration suggesting its implications in inducing angiogenesis
26925746 serum levels elevated in ovarian cancer
26909926 The VEGF-C936T polymorphism does not discriminate patients with progressing autosomal dominant polycystic kidney disease from controls.
26909925 The 1p/19q status and VEGF mRNA expression in tissues could be used in combination to predict the prognosis of gliomas.
26907493 ANDV caused long-term elevated levels of eotaxin-1, IL-6, IL-8, IP-10, and VEGF-A that peaked 20-25 days after infection
26905425 altering the amount of VEGF signaling in endothelial cells by stimulating them with different VEGF concentrations triggered distinct and mutually exclusive dynamic Ca(2+) signaling responses that correlated with different cellular behaviors.
26890264 increased expression of VEGF-A and VEGFR-2 mRNA in neointima compared to normal aorta; a significantly higher protein content of VEGF-A and VEGFR-2 in neointima samples compared to controls was also observed; results indicate possible involvement of VEGF-A and VEGFR-2 system in the pathologic process of neointima formation after vascular interventions
26882471 Collectively, we found that ZEB1-expressing breast cancer cells increase VEGFA production and thus stimulate tumor growth and angiogenesis via a paracrine mechanism.
26882120 ENO1 was demonstrated to be up-regulated by HIF-1alpha in retinal pigment epithelial cells in response to hypoxia, without influencing VEGF secretion.
26873137 VCAN and VEGF were associated with survival in CRC patients with PM after CRS and HIPEC
26868378 increased peritoneal permeability in ovarian cancer is due to down-regulation of adhesion proteins via tumor derived VEGF.
26861446 Metformin simultaneously increases VEGFA and reduces CXCL10 and TIMP1 in CD34(+) cells in a model of the diabetic state combined with hypoxia to stimulate angiogenesis.
26852650 Genetic interactions of SNPs in CARD14, SENP1 and VEGFA might represent a functional mechanism in the pathogenesis of high altitude polycythemia.
26842181 Although none of the polymorphisms were significantly associated with breast cancer, some of the VEGF genotypes may influence tumor growth through an altered expression of VEGF and tumor angiogenesis.
26840372 The aim of this study was to investigate microRNA-497 (miR-497) expression and its role in development of colorectal cancer.
26830037 Allelic polymorphisms in common VEGF single nucleotide polymorphisms was associated with Recurrent spontaneous abortion samples and haplotypes with at least one minor allele showing an association with RSA pathogenesis.
26828991 Serum concentrations of HIF-1alpha (t=25.53, P<0.05) and VEGF (t=12.10, P<0.05) in early stage group were significantly higher than those in normal group.
26827826 In conclusion, this study revealed that miR-26b suppresses NSCLC metastasis by targeting MIEN1 via NF-kappaB/MMP-9/VEGF pathways, implicating a potential prognostic biomarker and therapeutic target for NSCLC treatment.
26825024 VEGF polymorphisms might be important indicators of disease activity and synovial lesions, and prognostic factors in evaluating the treatment effectiveness in rheumatoid arthritis.
26823724 Suggest that miR-195, a tumor suppressor miRNA, contributes to the lung metastasis of HCC by negatively regulating FGF2 and VEGFA expression.
26822586 HO-1 inhibitor, ZnPP, possessed the properties of anti-tumor agent by decreasing HIF-1alpha levels, blocking VEGF production, impairing tumor angiogenesis, and inhibiting tumor growth.
26805761 VEGF/NRP-1axis promotes progression of breast cancer via enhancement of epithelial-mesenchymal transition and activation of NF-kappaB and beta-catenin.
26798059 these data demonstrate that FGF-2 priming enhances the angiogenic potential of SHED through the secretion of both HGF and VEGF.
26785251 Results show that aqueous humor levels of VEGF-A and PlGF were significantly elevated in the eyes with neovascular glaucoma, and there was a positive correlation between the levels.
26783521 Our data indicated that Eag1 promotes osteosarcoma proliferation and migration, at least in part, by targeting STAT3-VEGF pathway.
26782587 VEGF and MMP-9 are overexpressed in lung adenocarcinoma tissues, and they have a synergistic effect on the invasion and metastasis of adenocarcinoma.
26782573 VEGF mediates shock wave-induced endothelial cell proliferation in a cell-autonomous manner.
26782388 VEGF could be a potential biomarker for HCC, while AFP could be used to distinguish between patients with HCC and cirrhosis or HCV.
26773192 Plasma levels of VEGF were elevated in endometriosis patients compared with controls.
26738492 Data highlight the importance of the catalytic activity of PIMT to mediate VEGF effects during endothelial cell migration and tube formation in angiogenesis.
26730574 Results identified following parameters as statistically significant independent confounders of vascular endothelial growth factor-A (VEGF-A) measurements: analyzing center, anticoagulant, centrifuge, analyzing method and sex of the proband.
26728374 Data show that cryptotanshinone (CTS) could down-regulate the expression of vascular endothelial growth factor (VEGF) and inhibit angiogenesis in U2OS osteosarcoma cells.
26718740 activation of TLR7 upregulated the expression levels of IFN-lambda1 and MMP-9 were increased by ~3 fold, whereas other genes (p53, PTEN, TIMP-1) were upregulated by ~2 fold, and VEGF was marginally upregulated after 10 min.
26718330 miR-497 inhibited the growth of tumors and reduced angiogenesis in a nude mouse xenograft tumor model, which was probably caused by the downregulation of pro-angiogenic molecules, such as VEGF and HIF-1alpha.
26718123 The results indicated that vascular endothelial growth factor A (VEGFA) was a direct target of miR-206 in renal cancer cells. Further studies revealed that upregulation of miR-206 inhibited renal cancer cell proliferation, invasion and migration
26712576 The administration of bFGF alone or in combination with VEGF improved the quality of postgraft human ovarian tissue, though VEGF, regardless of different concentrations, did not influence effect of bFGF.
26709129 Negative for VEGF/VEGFR2.
26708340 Both placental NRP1 and VEGF were expressed at lower levels in women with pre-eclampsia and homocysteine-treated mice, which may contribute to endothelial damage.
26706786 diagnostic value of soluble CD40 ligand (sCD40L) and vascular endothelial growth factor (VEGF) for Alzheimer's disease
26701102 the VEGF-A ACGG haplotype from VEGF-A -2578, -1498, -1154, and -634 was significantly associated with an increased recurrence of renal cell carcinoma (OR = 3.34, 95% CI = 1.03-10.91;the combination of high urinary total arsenic level and VEGF-A risk haplotypes affected the OR of renal cell carcinoma recurrence in a dose-response manner.
26678613 VEGF-A is a promising target for molecular fluorescence endoscopy because it showed a high protein expression, especially in sessile serrated adenomas/polyps and Lynch syndrome
26676934 TMP upregulated the expression of prolyl hydroxylase (PHD)2, reduced the protein and mRNA expression levels of vascular endothelial growth factor (VEGF), and reduced the expression of HIF-1alpha only at the protein level, not at the mRNA level in HUVECs, in a concentration-dependent manner
26676225 High VEGF expression was subsequently correlated with a short overall survival rate for patients exhibiting lymph node metastasis (P=0.0128); however, there was no significant difference in overall survival rate regarding the expression levels of TP and CD34
26667022 The melanoma cell lines showed different growth patterns in the brain, and these differences were associated with differences in expression of the angiogenic factors VEGF-A and IL-8 and the matrix metalloproteinases MMP-2 and MMP-9.
26662393 we discovered that the VEGF +936C/T gene polymorphism influences the response to chemotherapy and overall survival of NSCLC patients.
26662142 Immunohistochemical reaction for VEGF was different in the gingival mucosa fragments with papilloma compared with condyloma acuminata samples.
26662133 serum VEGF (vascular endothelial growth factor) and its inter-relation with the severity of microvascular damage, was assessed.
26654980 Results show that senescent cells disrupted the expression of two major players in age-related Macular Degeneration: VEGF and CFH.
26647818 downregulated miR429 functioned as a tumor suppressor by restraining cellular proliferation and migration, and inducing apoptosis, as well as targeting VEGF in Clear cell renal cell carcinoma cells.
26647730 hVEGF enhanced pulp cell proliferation and neovascularization, and markedly increased formation of reparative dentin in dental pulp.
26630663 These results suggest that lymph node lymphangiogenesis occurs before metastasis in OSCC. VEGF-A and VEGF-D play critical roles in this process.
26627848 High expression of VEGFA is associated with astrocytomas.
26627607 Identify a mechanism of VEGF overexpression in liver and mesentery that promotes pathologic, but not physiologic, angiogenesis, via sequential and nonredundant functions of CPEB1 and CPEB4.
26625311 Metformin inhibits breast tumor angiogenesis and suggest role of HIF-1alpha-VEGF signaling axis in mediating HER2-induced tumor angiogenesis.
26619025 The expression of the neural stem cell marker Sox2 is associated with eyes with increased VEGF-A expression and tumor invasiveness.
26615857 VEGFA genetic variations might influence response/resistance of FOLFIRI plus cetuximab treatment in metastatic colorectal cancer patients.
26615570 Observed highly significant reductions in the concentration of circulating interleukin (IL)-16, IL-7, and Vascular Endothelial Growth Factor A (VEGF-A) in encephalomyelitis/chronic fatigue syndrome patients.
26615568 in vitro study supports previously reported observations of elevated VEGF and chemokines in tear fluids of dysfunctional tear syndrome (DTS) patients, reiterating the role of inflammatory reactions in DTS
26600515 our study suggests that the TT genotype of VEGF +936C/T genetic variants is associated with an increased risk of osteosarcoma
26600499 This meta-analysis suggests the VEGF +405 C/G polymorphism confers susceptibility to psoriasis in Asians, and that the -460 C/T and -1154 A/G polymorphisms confer susceptibility to psoriasis in Europeans.
26587841 This study provides further evidence that a SNP in the VEGF gene may contribute to the comorbid conditions of dialysis patients
26586335 ERRalpha suppression inhibits angiogenesis in HUVECs
26577912 Peritoneal VEGF-A expression is regulated by TGF-beta1 through an ID1 pathway in women with endometriosis
26573068 Compared with p53 and siVEGF single transfections, the Pvp53 coexpression plasmid significantly increased the proportion of apoptotic cells and inhibited cell motility and proliferation.
26572705 inhibition of miR566 expression increases the expression levels of VHL, decreases the expression levels of VEGF, and inhibits the invasive and migratory abilities of glioblastoma.
26562248 High(Ang-2/VEGF) serum levels could be exploited as a new valuable integral biomarker in NSCLC.
26558525 VEGF genetic polymorphisms, -2578C>A and -634C>G, may be associated with an increased Tetralogy of Fallot risk
26556286 Vascular endothelial growth factor A (VEGF) levels is suggested to have a role in the pathophysiology of depression.
26553653 Angiogenic isoforms of VEGFA are hypothesized to promote spermatogonial stem cells (SSC) self-renewal, and the divergent isoforms are thought to balance one another to maintain SSC homeostasis in vivo. [review]
26553067 Our meta-analysis confirmed the association between the VEGF rs2146323 polymorphism and the risk of diabetic retinopathy.
26544730 our results indicate that KLF5 promotes angiogenesis of bladder cancer through directly regulating VEGFA transcription
26542886 our data suggested that VEGFA contributes to lung cancer progression by inducing a network of angiogenic factors, which might offer potential for therapeutic intervention
26535706 the VEGF -634 G/C polymorphism may not be related to the development of cancer (Meta-Analysis)
26535684 the VEGF polymorphisms may contribute to osteonecrosis of the femoral head (Meta-Analysis)
26531769 Study demonstrated that NAMPT, VEGF and HER2 were overexpressed in breast tumors as well as in the serum and their circulating levels declined after tumor removal, suggesting a clinical application of this triplet as biomarker for breast cancer diagnosis.
26510548 VEGFR2, the main target of VEGFA-induced angiogenesis, was underexpressed in BA, and VEGFA was decreased in most BA patients.
26501555 Low level of VEGF may have a role in poor clinical outcome of coronary heart disease patients after Percutaneous Coronary Intervention treatment
26489635 Increased plasma renin, AT and VEGF might play a role in the onset or development of superficial infantile hemangiomas.
26489624 ANGPT1, ANGPT2, and VEGF are associated with development of acute graft-versus-host disease after allogeneic hematopoietic stem cell transplantation.
26485685 miR-497 has a prominent role in suppression of VEGF-A-mediated non-small cell lung cancer cancer cell growth and invasion.
26485166 co-immobilizing of specific ratios of EGF and VEGF demonstrated a synergistic effect on cell survival compared to each GF captured alone.
26484606 VEGF gene silencing could inhibit the cell proliferation, migration and invasion of RCC 786-O cells; inhibition of VEGF protein expression could prevent transplanted RCC growth and tumor angiogenesis.
26476711 VEGF has a role in outcome of hepatocellular carcinoma treated with sorafenib [meta-analysis]
26476544 Our findings suggest a strong association between the VEGFA and VEGFR2 polymorphisms and adverse clinico-pathological parameters in chronic myeloid leukemia, also found significant genotype interactions in VEGFA and VEGFR2 genes in elevated risk for chronic myeloid leukemia susceptibility.
26475697 The -2549 I/D polymorphism in the VEGFA gene in men might be associated with idiopathic recurrent spontaneous abortion.
26470709 Real-time PCR and dual-luciferase assay showed CDK11(p58) inhibited the mRNA levels of VEGF and the promoter activity of VEGF
26467187 Human lung-resident macrophages express CB1 and CB2 receptors whose activation inhibits the release of angiogenic and lymphangiogenic factors
26466227 the VEGF-C936T polymorphism was not found to be associated with age-related macular degeneration.
26463632 Bis(2,3-dibromo-4,5-dihydroxybenzyl) ether downregulate the expression of VEGF and VEGFR, and simultaneously regulates VEGF signaling pathway to prevent angiogenesis.
26458588 These studies demonstrate for the 1 st time that Cur-NLC exerts an antitumor effect on HepG2 cells by modulating VEGF/VEGFRs signaling pathway.
26453303 Considering the actions of IL-8 and VEGF, our results suggest that NE contributes to the pathogenesis of COPD by enhancing inflammation and apoptosis
26451370 These results demonstrated that the cotransfection of BMP-2 and VEGF into microencapsulated C2C12 cells is of potent utility for the potentiation of bone regeneration.
26451090 Type IV collagenases, MMP-2 and MMP-9, play important roles in hair cycle, and this could be mediated by induced expression of VEGF, IGF-1, and TGF-beta.
26450919 Using in vivo mouse models, we demonstrated that tamoxifen induced a dose-dependent shift in endogenous uterine angiogenic balance favoring VEGF over PEDF.
26446987 HIV-1 Tat upregulates VEGFA (VEGF) expression in HUVEC and EA.hy926 cells
26446654 In ARPE-19 cells[Retinal Pigment Epithelium], resveratrol significantly inhibited HIF-1alpha and VEGF in a dose-dependent manner, by blocking the PI3K/Akt/mTOR signaling pathway and by promoting proteasomal HIF-1alpha degradation.
26445225 TGF-beta/Smad signalling pathway and VEGF-A participate in the pathogenesis of sarcoidosis.
26432919 apart from being less robust and dysregulated as compared with N-ECFCs, VEGF-induced Ca(2+) oscillations modestly stimulate PMF-ECFC growth and in vitro angiogenesis.
26432868 recruitment of base excision DNA repair (BER) enzymes in response to hypoxia-induced promoter modifications was required for transcription complex assembly and VEGF mRNA expression.
26429165 vascular endothelial growth factor may have a role in increased microvascular density in women with endometrial hyperplasia, and possibly a relationship with uterine natural killer cells
26429157 DOG-1, VEGFA and p16 are expressed in cutaneous basal and squamous cell carcinomas
26427711 Our results imply that mTOR regulates the expression of VEGF and is involved in breast cancer progression
26422603 VEGFA and VEGFB associated sub-network, kinase insert domain receptor (KDR), fibronectin 1 (FN1), transforming growth factor beta induced (TGFBI) and proliferating cell nuclear antigen (PCNA) found to interact with at least two of the three hub genes.
26422107 Our study demonstrate that VEGF -2578A/C and +936C/T polymorphisms are among the factors determining the individual peculiarities of NSCLC course in this population and can be used for clarifying the prognosis of the disease.
26416045 No significant association was identified between VEGF +405 G/C polymorphism and breast cancer risk
26408740 Low expression of VEGF is associated with poor response to chemotherapy in Metastatic Renal Cell Carcinoma.
26403405 CoCl2 was proved to control MCF-7 cell proliferation and increase expression of HIF-1alpha, CXCR4 and VEGF.
26402430 Study showed downregulation of miR-140 in colorectal cancer (CRC) closely associated with overall survival. VEGFA, its target, is up-regulated in CRC cells suggesting a tumor suppressive role of miR-140-5p in CRC and progression by targeting VEGFA.
26400342 AA genotype of VEGF -2578C/A genetic variants is associated with increased risk of renal cell carcinoma.
26400284 The AA and CA+AA genotypes of the VEGF -2578C/A polymorphism might modify the risk of osteosarcoma in a Chinese population.
26398444 Collectively, our results indicated that miR125a regulated the paracrine of VEGF-A in gastric cancer and thereby controlled the angiogenesis of the tumor.
26392741 The loss of HIF-1alpha by hypoxic lens epithelial cells decreases the expression of the epithelial to mesenchymal transition marker proteins without sacrificing the levels of the prosurvival protein VEGF.
26372896 oxaliplatin-based chemotherapy increases ERCC1 and DPYD expression levels; bevacizumab induces VEGFA expression in metastatic colorectal cancer
26361270 Increased osteoclast formation and higher VEGF levels may contribute to acroosteolysis in systemic sclerosis patients.
26350463 results show that activation of CRH receptors by CRH ligands stimulates VEGF-A expression in intestinal epithelial cells through the cAMP/CREB pathway
26346135 Data show that both VEGF/VEGFR and mTOR inhibitors indicated antitumour activity following PD-1/PD-L1 blockade.
26345918 Vascular endothelial growth factor gene is associated with hypertensive cerebellar hemorrhage and rehabilitative treatment
26345822 This study aimed to analyze the association between the 405G/C and -2578C/A polymorphisms of the vascular endothelial growth factor (VEGF) gene and breast cancer risk by meta-analysis
26345754 cancer. In summary, this study found that the VEGF -634G/C gene polymorphism was associated with an increased risk of osteosarcoma
26341082 Dysregulation of the vascular endothelial growth factor and semaphorin ligand-receptor families in prostate cancer metastasis
26339416 Report VEGF expression in giant cell tumor of bones.
26339385 Immunohistochemical expression of COX-1 and VEGF is associated with poor prognostic parameters in renal cell carcinoma.
26336994 Data suggest that ppp-RNA orchestrating retinoic acid-inducible gene-I protein (RIG-I) activation to 5'-triphosphate siRNA targeting VEGF (ppp-VEGF) could be strategy for cancer therapy.
26336827 Results indicate that microRNA miR-497 directly inhibited the 3'-untranslated regions (3' UTRs) of vascular endothelial growth factor A (VEGFA) and astrocyte elevated gene-1 (AEG-1).
26336029 VEGFA may represent a candidate gene contributing to venous thromboembolism development in chemotherapy treated cancer patients. -1154G/A SNP might provide useful clinical information on the efficacy and toxicity of bevacizumab in metastatic patients.
26327764 Carvedilol has an anti-angiogenic effect on HUVECs. This inhibitory effect is mediated by VEGF-induced Src-ERK signaling pathways.
26325091 colocalization of HuR and the distal part of the VEGFA 3'-untranslated region (UTR) in the cytoplasm. We propose that under hypoxia-like conditions, HuR enhances VEGFA mRNA translation.
26323923 High expression of COX-2, EGFR, and VEGF is an unfavorable prognostic factor in ESCC, and could be used as a poor prognosis indicator for the ESCC patients.
26320510 High VEGF expression is associated with Metastatic Colorectal Cancer.
26318037 The prognosis was poorer in colorectal cancers that expressed both PROK1 and VEGF relative to the cases that expressed only 1 protein, and the expression of both proteins was found to be an independent prognostic factor.
26313304 Vascular endothelial growth factor-A, -C and -D mRNA, and VEGF-A and -D protein were expressed by all CM and UM cell lines, while VEGF-C protein was only expressed by UM cell lines.
26310563 data indicate that the inhibition of VEGF expression by RNAi reduces VEGF mRNA levels, and inhibits angiogenesis and tumor growth in RCC, providing a future treatment option for RCC.
26308290 Data suggest differences in regulation of expression of PEDF (up-regulation) vs. VEGF (down-regulation) in granulosa cells explain reduced risk of ovarian hyperstimulation syndrome due to ovulation induction using GnRH/GNRHR agonists rather than hCG.
26307351 Dual-poly-siRNA carrying glycol chitosan nanoparticles demonstrated successful VEGF/Bcl2 gene silencing in prostate tumors.
26305668 This study showed an association between the VEGF -1154G/A polymorphism and RIF in Brazilian women
26302981 Elevated sVEGF is associated with an increased risk of VTE in patients with cancer.
26301881 Data show that serum interleukin 17 (IL-17) was elevated and the levels positively correlated with vascular endothelial growth factor (VEGF) concentration in non-small-cell lung cancer (NSCLC) patients.
26299712 In hyperuricemia, miR-92a downregulation increased KLF2 expression, subsequently inhibiting VEGFA, which resulted in decreased angiogenesis.
26299356 Upregulation of CLOCK is associated with the expression of HIF-1alpha and VEGF in varicose veins.
26287601 NCOA1 potentiates breast cancer angiogenesis through upregulating HIF1alpha and AP-1-mediated VEGFa expression
26279254 time changes of sCD40L over 1 month after myocardial infarct onset were associated with G894T eNOS polymorphism and with the VEGF concentrations, but not to the platelet CD62P expression
26275133 GRS using ARMS2, CFH, TNFRSF10A, VEGFA, and CFI was significantly associated with second-eye involvement. Genetic risk has high predictive ability for second-eye involvement of AMD.
26274923 The overexpression and accumulation of VEGFA protein in the glomerular basement membrane leading to podocytes injury in Alport syndrome patients.
26274316 These results demonstrate that ATO inhibits the growth of HUVECs and induces apoptosis by downregulating VEGFA.
26269515 we show that VEGFA signaling from TIE2(hi) TMEM macrophages results in local, transient vascular permeability and tumor cell intravasation.
26268996 This large study highlights the prognostic importance of VEGF-A and VEGFR-2 stromal expression in prostate cancer.
26261495 Alternative splicing of APP, VEGFA and NUMB may play an important role in pathogenesis of pancreatic ductal adenocarcinoma.
26260219 Results show that brain metastasis in advanced gastric cancer was associated with the expression of VEGF.
26259755 High VEGFA expression is associated with Gastric Adenocarcinoma.
26254223 Suggest curcumin as a inhibitor of VEGF-VEGFR2 signaling pathway in endothelial cells to prevent tumor growth.
26248134 Autoantibodies in dilated cardiomyopathy induce VEGF expression in cardiomyocytes.
26239613 The results revealed that DP inhibited the expression of VEGF and HIF-1alpha through the PI3K/Akt/mTOR signaling pathway, confirming that DP may be a potential therapeutic candidate for breast cancer.
26239164 Transplantation of VEGF-165transfected endothelial progenitor cells for the treatment of limb ischemia is an efficient treatment strategy.
26235535 With respect to the better understanding of potential hMSC-based periodontal regeneration strategies, we propose hMSC-derived VEGF release as a mechanism in the recruitment of hard tissue-forming cells to alveolar bone sites in need of regeneration.
26232913 We will then discuss how ECFC insensitivity to VEGF stimulation in cancer patients could underpin their well-known resistance to anti-VEGF therapies.
26232605 High expression of VEGF-A is associated with triple negative breast cancer.
26217879 The prepared aptasensor exhibited high sensitivity and good selectivity and reproducibility. The aptasensor was successfully applied to the determination of VEGF165 in serum sample of a lung cancer patient
26214803 Significant Correlation between Retinal Venous Tortuosity and Aqueous Vascular Endothelial Growth Factor Concentration in Eyes with Central Retinal Vein Occlusion.
26214642 Review/Meta-analysis: overall survival of the VEGF-positive group with ovarian cancer was significantly poorer than the VEGF-negative group. However, VEGF positivity seems not to be connected with DFS and PFS.
26214443 The -2578C/A and +936C/T polymorphisms in the VEGF gene may play a role in the etiology of renal cell carcinoma.
26209639 Data show that interleukin-1 receptor type 2 (IL1R2) forms a complex with c-Fos proto-oncogene protein and activates the interleukin-6 (IL-6) and vascular endothelial growth factor A (VEGF-A) promoters.
26209503 comprehension of the association of specific SNPs and TFB could be an essential part in our understanding of individual differences of VEGF regulation and course of diseases
26205065 Serum levels of VEGF, IL-17, IL-10 and TNF-alpha were reduced in the pre-eclamptic pregnant women when compared with their normotensive peers.
26204653 EG-VEGF is overexpressed mainly in high-grade ovarian carcinomas (type II) than in low-grade ones. Eg-VEGF expression points out the relationship between the enhanced potential for tumor angiogenesis and the tumor aggressivity.
26201022 strong expression of TGF-beta1, IL-1beta and VEGF was evident in the extracellular matrix and in the cytoplasm of fibroblasts and myofibroblasts in Dupuytren's nodular tissues, as compared to control tissues
26197083 Genes expression of MMP9, VEGFA and TIMP1 in peripheral blood leukocytes may play a pivotal role in regulation of progression of bladder cancer; TIMP1 expression may be important factor for early recurrence.
26196186 VEGF isoforms have different effects on breast cancer cell line colonisation in vivo.
26193215 The results of this study suggest that the expression of VEGF-A and ORM-1 may be associated with two mechanisms (angiogenesis and tumor structural viscosity) that may influence tumor growth in odontogenic myxoma.
26191229 High VEGF plus VEGFR expression and AKT phosphorylation are highest in leukocytes of remission patients, suggesting VEGF signaling as a cause of reduced apoptosis susceptibility upon treatments.
26191163 Our findings indicate that miR-199a may attenuate the angiogenic potential of ESCs under hypoxia partly through HIF-1alpha/VEGF-A pathway suppression.
26190445 VEGF family members may have important roles in myocardial lymphatics in healthy and in cardiac disease.
26181364 Direct binding of CD44v6 to HGF and VEGF was demonstrated in pull-down assays
26174951 inhibitory effect of RSV on the HIF-1alpha/VEGF/VEGFR2 signaling axis is mediated, at least in part, through SIRT1
26165685 serum VEGF levels were significantly associated with tumor metastasis in small cell lung cancer.
26158818 Data indicate that the vascular endothelial growth factor (VEGF) single nucleotide polymorphisms (SNPs) showed no formidable linkage in studied epithelial ovarian cancers.
26158180 The expression of VEGF and SSTR2 were associated with progression and prognosis of gastric cancer.
26156593 Data suggest that serum fetuin-A (FETUA/AHSG) concentrations are signi fi cantly positively associated with serum VEGFA (vascular endothelial growth factor A) levels in patients with newly diagnosed type 2 diabetes.
26154735 The aim of this study was to investigate the association of -2578C>A and -1154G>A polymorphisms in the VEGF gene with susceptibility to hypertension.
26143638 Data suggest that dual inhibition of vascular endothelial growth factor (VEGF) and CA125 protein might bring about a better outcome for patients with epithelial ovarian cancer (EOC).
26137585 MET suppresses VEGFR2 protein by inducing its endoplasmic-reticulum-associated degradation (ERAD), via intracrine VEGF action.
26130419 C936T polymorphism of the VEGF gene and the C242T polymorphism of the p22phox gene are not correlated with diabetes mellitus type 2 and distal diabetic polyneuropathy.
26126033 VEGF and VEGFR2 and angiogenic activity are present in dental follicles and dentigerous cysts and may contribute to local bone resorption for tooth eruption or the development and progression of dentigerous cysts
26125893 TNF-alpha, VEGF, and MMP-3 might directly participate in the differentiation of fibroblasts into osteoblasts in ankylosing spondylitis.
26125867 Three of these, PIK3R1, VEGFA, and ITGB1, are known to be associated with preeclampsia or preeclampsia-related biological processes
26118134 study suggests that I/D polymorphism in the promoter region of the VEGF gene is not associated with DN in type 2 diabetes patients, but might have a role in development of non-diabetic nephropathy
26111775 DLL4 and VEGFA expression was closely related to tumour diameter, clinical stage, histological grade and lymph node metastasis.
26107202 High VEGF mRNA expression significantly correlated with the total number of non- proliferative vessels and total number of vessels in the liver metastases.
26099724 The expressions of VEGF, HER-2, and EGFR mRNA were related to the lymph node metastasis in ESCC and pathologic differentiation degree.
26090403 MEG3 levels are inversely associated with VEGF levels, suggesting that MEG3 may be involved in OA development through the regulation of angiogenesis
26084601 upregulation of miR-107 in glioma cells inhibits VEGF expression.
26078569 Suggest that VEGF expression correlates with prognosis in gastrointestinal stromal tumors.
26076727 cell contact between mesenchymal stromal cells (MSCs) and B cells resulted in increased production of vascular endothelial growth factor (VEGF) by MSC facilitating AKT phosphorylation within the B cell
26074693 Report alternative splicing of VEGFA in colorectal cancer.
26067906 Results from meta-analysis suggest that both the VEGF +936C/T and -634G/C polymorphisms influence breast cancer susceptibility and tumor growth, instead of metastasis.
26065377 Gene phenotypic analysis demonstrated that C allele of +405G/C in VEGF gene was significantly associated increased risk of lung cancer in males.
26062754 Treprostinil indirectly regulates endothelial colony forming cell angiogenic properties by increasing VEGF-A produced by mesenchymal stem cells.
26062523 IRX2 modulates the expression levels of MMP2 and VEGF in an AKTdependent manner.
26058869 The oral squamous cell carcinoma (OSCC) tissue VEGF mRNA level can be used to predict the progression and prognosis of OSCCs in Taiwan.
26052072 The cut point of mean intensity (MI = 40) was used to investigate as an independent predictor for PFS (p = .021) and OS (p = .025), respectively, due to a strong correlation between MVD counts and VEGF expression in patients with invasive breast cancer
26048020 VEGF is down regulated in patients with hepatocellular live cancer and a prognostic factor.
26047642 A dynamic axis of interaction between human airway smooth muscle cells and epithelial cells that amplifies CXCL8, VEGF, COX-2, and amphiregulin production.
26044558 Our study suggests that -2578C/A and +460T/C polymorphisms of VEGF modulate the risk of developing renal cell carcinoma in Chinese population
26040037 VEGF expression in athletes correlates with the type of energy expenditure and oxygen consumption during physical exertion.
26030799 Platelets are not only important in the early stages of the healing process (clot formation, direct release of growth factors), but also can influence the whole process of tissue regeneration by modulating synthesis and release of VEGF, bFGF and IL-10 by mononuclear leukocytes.
26021863 Our findings demonstrate for the first time that CHIP may be involved in RCC angiogenesis through regulating VEGF secretion and expression of VEGFR2.
26019468 Higher serum VEGF levels and the lower tryptase levels following TACE may be potential biomarkers changing in response to therapy in HCC.
26007326 Important regulatory roles of PPARG and VEGF in the vascular processes associated with diabetes and atherosclerosis.
26007312 Higher sFlt-1 and lower VEGF levels in the group with preeclampsia, as well as higher sFlt-1 levels in small for gestational age neonates, reflect a predominance of antiangiogenic mechanisms in preeclampsia and growth restriction.
26007152 VEGF +405G>C polymorphism could be associated with immune-mediated inflammatory diseases, and the correlation might vary with ethnic groups. [Meta-Analysis]
26002049 Polymorphisms in VEGFA gene affect the antihypertensive responses to enalapril
25998098 The recent large-scale genetic studies indicate that common polymorphisms of the genes encoding VEGF-A and VEGFR-2 are not consistently associated with Bronchopulmonary dysplasia (BPD)
25993872 IGF-II, TGF-beta1 and VEGF-A and its receptor in malignant tumor tissue, as well as increasedplasmin release from proenzyme and MMP-3 activationis apparently associated with the formation of pathogenic mechanism of vasculature development
25992764 The results support the hypothesis that the carrier state of VEGF 634 C/G polymorphism has an impact on the risk of ROP in infants. A broader study may suggest that this marker could be used as an indicator in the screening for ROP.
25984730 findings suggest that the VEGF +936 C/T polymorphism may be a risk factor for endometriosis development and the VEGF +936 T allele is associated with an increased risk of stages III-IV endometriosis in the Tunisian population
25982407 bisphenol A and 17beta-estradiol impact on vascular endothelial growth factor A and its receptor expression
25979342 Heparin influences VEGF receptor-1, VEGF receptor-2, and neuropilin-1 through distinct mechanisms and regulates VEGF-induced signaling.
25977072 plasma VEGF levels before treatment were lower in patients with schizophrenia and that their VEGF levels increased after treatment.
25975204 VEGF affects the maturation, differentiation and activity of dendritic cells in hypertensive disorders of pregnancy.
25973082 Decreased peri-therapeutic VEGF expression in mCRC patients could probably be used to predict responsiveness to bevacizumab and subsequent PFS in clinical practice.
25973067 Report endothelial cell pathology and VEGFA expression in liposarcomas versus non-lipomatous soft tissue tumors.
25972323 Our results support that osteopontin regulates ICAM-1 and VEGFA expression mainly in triple-negative/basal-like breast carcinomas
25970161 Serum VEGF level was insignificantly lower in dengue patients whereas VEGFR1 was significantly higher (P = 0.01) and VEGFR2 was significantly lower (P = 0.005) compared to controls
25966978 the A2B AR activation-driven angiogenesis via cAMP-PKA-CREB mediates VEGF production and PI3K/AKT-dependent upregulation of eNOS in HMEC-1
25966208 VEGF +1612A/G, -634G/C, and +936T/C polymorphisms were not related to the response to chemotherapy and clinical outcome of osteosarcoma patients.
25963717 A strong positive correlation between the mRNA expression levels of HIF-2alpha, CA9, VEGF, GLUT-1 and OPN suggests a specific hypoxia-associated profile of mRNA expression in glioblastoma multiforme
25956512 VEGF SNPs i.e., rs2010963 C allele and rs3025039 T allele might be associated with PDR occurrence.
25955730 Data show that CC vs. CA of the VEGF -2578 C/A polymorphism and CC+CT vs. TT of the VEGF -460 C/T polymorphism might be predictive factors of responsiveness to chemotherapy in colorectal cancer. [meta-analysis]
25951999 VEGF expression was found in the submucosa and subserosa layers only in the placenta. No VEGF was seen in tissue from patients with urinary obstruction or fetal ureteropelvic junction without urinary obstruction.
25948774 VEGFR blockade inhibits the process of tumor vasculogenesis occurring during tumor hypoxia whereas the effect of VEGF inhibition appears restricted to differentiated endothelial cells.
25929323 Ezrin, CD44, and VEGF are over-expressed in GCTB tissue and its adjacent noncancerous tissue samples and may play an important role in the occurrence, invasion, metastasis, and recurrence of GCTB.
25925846 This study reflects routine clinical use of everolimus in a large sample of patients with metastatic renal cell carcinoma . Favorable efficacy and safety were seen for everolimus after previous therapy with one VEGF-targeted agent
25921830 Only domain III of SPARC binds VEGF.
25919050 our study does not support a role for TGF-beta1 and VEGF in causing cancer among transplant recipients treated with CNIs.
25914140 Astrocytes from Huntington disease patients contained more VEGF-A, which triggers proliferation of endothelial cells and may be responsible for the augmented neurovascular changes.
25894998 VEGF plays dual roles on osteoclastogenesis in rheumatoid arthritis
25894981 Associations between genetic variations of vascular endothelial growth factor (VEGF) gene and the risk of TOF are investigated.
25894555 The current meta-analysis indicates that rs1570360, rs3025039, rs2010963, and rs3025020 polymorphisms of VEGF, increase recurrent spontaneous abortion susceptibility.
25893670 In patients with carotid plaques, both circulating and intraplaque polymorphonuclear neutrophils produce IL-8, VEGF and elastase, which are crucial for plaque development and progression.
25889301 VEGF is an autocrine growth factor in NSCLC signaling, at least in part, through NP1.
25887968 A lower vascular endothelial growth factor A mRNA gene expression level was independently associated with a higher risk of multiple sclerosis
25885592 Our results suggest that ANGPT2 is a marker of RCC. Additionally, ANGPT2 and TuM2PK significantly correlated with several adverse pathological features. Further studies are needed to determine clinical applicability.
25884029 Effusion VEGF correlates with pleural inflammation and fibrosis and may be targeted for adjunct therapy for tuberculous pleural effusion.
25878490 The hyperosmotic induction of AQP5 and VEGF in retinal pigment epithelial cells was in part dependent on activation of NFAT5.
25875799 Vascular endothelial growth factor +405G/C single nucleotide polymorphism was significantly associated with malignant transformation in intraductal papillary mucinous neoplasm.
25872462 Data suggest that plasma levels of VEGFA are down-regulated and levels of FGF2 (fibroblast growth factor 2) are up-regulated in type 2 diabetes mellitus (T2DM) patients with diabetic foot (DF) as compared to T2DM patients but without DF.
25862879 Monitoring the serum VEGF level is useful for predicting the response of aHCC to HAIC, as well as for predicting metastasis, tumor type and vascular invasion.
25862867 Survivin, via AKT and VEGF, seems to play an important role in oral melanoma and could represent an important prognostic marker of melanoma progression.
25853270 The data suggest that breath condensate of patients with pulmonary hypertension is characterized by increased levels of the angiogenic factors angiogenin, VEGF and bFGF as well as TNF-alpha, but not IL-8.
25847144 The expression of VEGF was not associated with the expression of T-cadherin in the gastric cancer tissue.
25846106 Because VEGF acts as a vascular permeability and growth factor, it could play a role, at least in part, in the pathogenesis of HHV-8-unrelated PEL-like lymphoma.
25835351 VEGF +936 C/T polymorphism may influence the risk for the development of Ovarian Cancer.
25830483 Study explored the influence of VEGF gradients (in a microfluidic device wound model) on the motility and chemotactic properties of P. aeruginosa; data provide evidence that while beneficial, VEGF, in excess, may aid colonization by P. aeruginosa.
25826664 Stabilization of the G-quadruplex at the VEGF internal ribosome entry sites represses cap-independent translation.
25825981 CD147 is a novel coreceptor of VEGFR-2 with a role in mediating its activation by VEGF
25824321 it was concluded that TGF-beta1, IGF-I/IGF-IR and VEGF-A overexpression is associated with the presence of aggressive tumors, which exhibit an increased probability of metastasis, a poor response to treatment and reduced survival rate.
25821815 Our findings point to a significant role of MMP-9 and VEGF in the pathogenesis of peritumoral brain edema in low- and high-grade meningiomas.
25821324 Retinal pigment epithelial cells exposed to adiponectin showed decreased expression of VEGF mRNA, protein whereas PEDF protein is unaltered and PEDF mRNA was increased.
25820820 Our results show that NSCLC patients exhibit high VEGF(PLT) and serum TGF-b1 levels, and VEGF(PLT) and TGF-b1 levels correlate with chemotherapy response to GP regimen.
25820249 these results demonstrate that FAK and Rac1 signalings coordinately regulate the dynamics of FAs during VEGF-induced migration of MSCs in varying neural differentiation states.
25818803 We conclude that co-transplantation of islets with VEGF-expressing hESC-MSCs allowed for at least a 50% reduction in minimal islet mass required to reverse diabetes in mice.
25815440 The well-known antioxidant Res effectively blocked these effects and reduced phosphorylation of nuclear factor (NF)-kappaB, an upstream activator of CXCR4. Furthermore, Res also suppressed VEGF secretion induced by SDF-1, a ligand of CXCR4
25804797 VEGFA isoform status and serum VEGF levels play a significant role in the progression as well as prognosis of oral cancer.
25802486 MicroRNA-152 represses VEGF and TGFbeta1 expressions through post-transcriptional inhibition of prorenin receptor in human retinal endothelial cells.
25792473 This is the first study from India on clinical and pathological correlation among urine VEGF, tumor tissue VEGF levels, and Micro Vessel Density (MVD) in urinary bladder cancer patients
25790539 Studied serum VEGF levels of 30 patients aged between 34 and 83 years with gastric cancer and 30 patients without malignant pathology.
25787827 The Circulating Levels of Selenium, Zinc, Midkine, Some Inflammatory Cytokines, and Angiogenic Factors in Mitral Chordae Tendineae Rupture.
25778843 These effects are mediated by downregulation of VEGF, VEGF-C and PDGF-B expression.
25778315 Abnormal expression of FOXP1 in renal cell carcinoma may create progression of tumor from low grade to high grade by regulating the HIF-1-VEGF pathway.
25775978 Data show that prohaptoglobin promotes angiogenesis via vascular endothelial growth factor (VEGF) and VEGF receptor2 signalling.
25769656 VEGF expression is mainly localized in pre- and osteoblasts in fetal bone.
25756047 There were no significant correlations between VEGF, sVEGF-R1, sVEGF-R2, and platelet counts in chronic urticaria and the healthy subjects
25755796 concluded VEGF polymorphisms were associated with coronary heart disease susceptibility
25753222 These observations imply that crosstalk between the VEGF and BMP-6 signaling pathways enhances osteogenic differentiation of MSCs.
25748833 Reactive oxygen species increase the activity/levels of gelatinolytic matrix metalloproteinases, and stimulate cytokine secretion in human periodontal ligament fibroblast.
25738867 the results of the present study indicated that VEGF and pro-inflammatory cytokines may be potential therapeutic targets in vestibular schwannoma.
25735814 bFGF promotes VEGF expression in chondrosarcoma via c-Src/p38 signal cascade, promoting endothelial progenitor cell-primed angiogenesis.
25735340 High serum VEGF level is associated with poor response to therapy in esophageal cancer.
25732057 The inhibition of OPN may reduce VEGF levels and suppress tumor progression. In vascular pathologies, these two cytokines mediate remodeling, but may also perpetuate inflammation and narrowing of the arteries.
25714003 Study shows that VEGFA rs2010963 polymorphisms may play a potential role in preterm complications.
25713884 VEGF G634C and VEGF C936T polymorphisms were not associated with the severity of colorectal cancer.
25713439 Studies indicate that patients most likely to benefit from anti-vascular endothelial growth factor and anti-vascular endothelial growth factor receptor (anti-VEGF/anti-VEGFR) therapy.
25710281 mRNA levels of VEGF were increased in muscle tissue of COPD patients compared to controls, which was most pronounced in the patients with high levels of muscle TNF-alpha.
25707392 This study provides evidence that functional germline polymorphisms in the VEGF pathway may help to predict outcome in mCRC patients who undergo oxaliplatin/5-fluorouracil chemotherapy.
25700976 Our results suggest that the miR-185, as a tumor suppressor, plays a pivotal role by inhibiting VEGFA in von Hippel-Lindau gene-inactivated clear cell renal cell carcinomas
25688362 Studied the effects of zeaxanthin on the VEGF and HIF-1alpha expression in the primary culture of human RPE cells. Hypoxia caused a significant increase of VEGF expression and accumulation of HIF-1alpha in RPE cells.
25688080 VEGF was found to be upregulated in cerebral cortex from Alzheimer's disease and vascular dementia post-mortem brain.
25681051 PLLA mat allowed a smart cargo that enabled the sustained release of VEGF and the delivery of cardiac stem cells, thereby synergistically inducing angiogenesis and cardiomyogenesis in acute myocardial infarction.
25672981 Transcriptomic data in patients with non-small cell lung cancer indicate that TP53 mutations are associated with higher VEGF-A expression.
25659996 Intestinal VEGF protein is reduced in human and murine necrotizing enterocolitis (NEC). Decreased VEGF production might contribute to NEC pathogenesis.
25659610 The VEGF -1154 GG genotype and the +936 T allele were found to be susceptible to acute rejection
25659153 Tanshinone IIA inhibits HIF-1alpha and VEGF expression in breast cancer cells via mTOR/p70S6K/RPS6/4E-BP1 signaling pathway.
25651716 Serum VEGF concentrations were significantly higher in long term peritoneal dialysis patients, and peritoneal effluent VEGF concentrations were significantly lower in patients receiving statins.
25648303 Our study provides a new insight into the role of VEGFA in NBL metastases by pointing to the role of stroma-derived intracrine VEGFA in osteoblastogenesis.
25643599 Under optimized conditions, the SERS signal was negatively related to VEGF concentration over the range 0.01-1.0 fM and the limit of detection (LOD) was as low as 22.6 aM
25641412 +405G>C polymorphism in VEGF might exert an influence on autoimmune diseases, with opposite effect observed in Asians and Caucasians. No association between the other four common SNPs (-2578C>A, -1154G>A and -460T>C) and autoimmune diseases susceptibility was confirmed (Meta-Analysis)
25641338 CXCL1 increases local tumor growth through activation of VEGF signaling.
25641131 the selected tag SNPs of VEGFA may not confer a susceptibility of schizophrenia in the Han Chinese population.
25640399 From the results of the present study a significant association of +936C>T and +405C>G polymorphisms in VEGF with increased esophageal cancer risk exists in the Kashmiri population.
25635747 Authors evaluates whether the VEGF single-nucleotide polymorphisms play a role in modulating susceptibility to CRC.
25634015 VEGF/CR and IL-6/CR have a role in glomerular pathological injury
25632198 Combined expression of estrogen receptor 1 and VEGF-A is a potential prognostic marker for gallbladder carcinoma patients.
25624724 RhoC protein may upregulate VEGF expression, thereby promoting tumor angiogenesis in esophageal squamous cell carcinoma.
25623525 HIF1alpha has a role in protecting cervical carcinoma cells from apoptosis induced by radiation via modulation of vascular endothelial growth factor and p53 under hypoxia
25619885 improvement in behavioral performance (open-field and grip-strength tests), as well as increased life-span was observed in rodents treated with NCAM-VEGF or NCAM-GDNF co-transfected cells
25617660 The analysis of complexes evidenced that VEGFA_121, VEGFA_145, VEGFA_183, VEGFA_189 and VEGFA_206, containing exons 7 and 8a, are able to interact with NRP-1 because they have the key regions of exons 7b and/or 8a.
25617075 the rs3025039 polymorphism was significantly associated with time to treatment failure and hypertension in patients treated with bevacizumab-based chemotherapy.
25613064 the serum level of IL-17F and the ratio of IL-17F/VEGF were positively associated with the numbers of CD3(+) CD4(+) T cells, which indicated that serum IL-17F could originate from PBMCs during the development of oral squamous cell carcinoma
25607509 Decreased vascular endothelial growth factor expression is associated with cell apoptosis in low-dose aspirin-induced gastric mucosal injury
25604142 There was no significant difference in genotype and allele distribution of VEGF -7C/T and VEGFR1 -710C/T polymorphisms between cases and control individuals (p > 0.05).
25601176 Silent brain infarctions are associated with favorable outcomes in patients with first-ever acute lacunar infarction and higher levels of VEGF may contribute to favorable prognosis.
25597268 Data reveal a new potential pathway in which VEGF promotes the invasion of ovarian cancer cells, partially via the down-regulation of Ezrin and Lamin A/C caused by increased expression of miR-205.
25596346 current meta-analysis reveals a significant association between VEGF -634G/C polymorphism and susceptibility to autoimmune diseases in Asian population.[meta-analysis]
25595406 Intra-arterial VEGF gene delivery by magnetic microspheres significantly increased DNA stability, transfection efficiency, and targeting specificity, resulting in exogenous VEGF overexpression and attenuated intimal hyperplasia in balloon-injured artery.
25588190 VEGF plays an important role in normal retinal vascular development
25586350 our data suggest that adiponectin may play an essential role in suppressing growth of prostate cancer cells through inhibition of VEGF-A-mediated cancer neovascularization.
25581570 this study suggested that AGE or MGO promoted VEGF and MCP-1 expression through activation of p38 MAPK signaling.
25579062 TrpC5 plays an important role in VEGF-mediated tumor angiogenesis, suggesting its potential clinical value for anti-angiogenesis therapy
25577253 Preoperative measurement of serum VEGF, survivin, and Smac/DIABLO may be of help in early detection of serous ovarian cancer and may provide important information about the patient's outcome and prognosis.
25577246 our results supported the idea that overexpression of VEGF183 promotes murine breast cancer cell proliferation in vitro and induces dilated intratumoral microvessels, and it plays a dissimilar role in comparison with that of VEGF189.
25575606 miR-214 suppresses VEGF expression and endothelial progenitor cell activities via direct binding to the 3'UTR of VEGF mRNA.
25573961 This meta-analysis supports that the VEGF +405G>C genetic polymorphism is not significantly associated with the risk of endometriosis.
25572735 blockade of CXCR6 signaling suppresses the growth and invasion of human hepatocellular carcinoma (HCC) cells through inhibition of the VEGF expression.
25569379 the complex structural remodeling of the matrix might reduce oxygen availability in the valve cusp contributing to the stabilization of HIF-1alpha that in turn induces a metabolic adaptation through the upregulation of VEGF
25560472 This review presents an update on the potential role of VEGF S and VEGF receptor-2 SNPs as prognostic and/or predictive markers in patients with breast cancer.
25560471 Considering the complications present in frail elderly patients, analysis of VEGF genetic polymorphisms in these subjects may further help in tailoring an angiogenic pharmacological strategy.
25551960 The -1154A or -2578A alleles of VEGF gene could significantly decrease the risk of ectopic pregnancy(EP) and might be po- tentially protective factors for EP development in Chinese women.
25550863 Our study suggests that rs699947 and rs2010963 polymorphisms may play a role in the pathogenesis of osteosarcoma.
25550804 cytoplasmic expression of VEGF, VEGFR2, PDGF-B, and PDGFR-beta in renal cell carcinoma tumour cells is different in various pathologic stage and cell type. Notably, VEGF and PDGF-B expression are higher in papillary than in clear cell renal cell carcinoma.
25550544 Angiogenic proteins, vascular endothelial growth factor, basic fibroblast growth factor and epithelial growth factor receptor are expressed in peripheral nerve sheath tumors of neurofibromatosis type 1.
25541696 Observations implied that VEGF gene polymorphisms might be associated with the susceptibility to obstructive sleep apnea.
25541433 findings show Specific VEGF variants (rs699947, rs1570360) and haplotype (CTGCCAG) may contribute to the development of cervical cancer among Tunisian women
25537504 Data suggest that the mechanism of gamma-H2AX on the angiogenic activity of hepatocellular carcinoma (HCC) might go through EGFR/HIF-1alpha/VEGF pathways under hypoxic conditions.
25534318 p27kip1 overexpression regulates VEGF expression, cell proliferation and apoptosis in cell culture from eutopic endometrium of women with endometriosis.
25531723 We also describe how the St. Gallen VHL multidisciplinary group is organised as an example of interdisciplinary cooperation in a tertiary hospital in Switzerland.
25524721 Vascular endothelial growth factor (VEGF) is one of the main inducers of ocular neovascularization, and several clinical trials have shown the benefits of neutralizing VEGF in patients with neovascular AMD or diabetic macular edema.
25520093 High serum VEGF level is associated with colorectal cancer.
25504455 upregulation of VEGF-A in idiopathic HMB-E is associated with a low pericyte coverage during the proliferative phase of intense angiogenesis, which may confer vessel fragility, possibly leading to excessive blood loss.
25488950 COX-2 and VEGF-A are related to tumour angiogenesis in human renal cell carcinoma.
25488616 Genetic polymorphisms in VEGFA may influence the susceptibility to chronic lymphocytic leukemia.
25488073 Our data suggest that the VEGFA rs2010963 genotype in recurrent glioblastoma is associated with longer progression-free survival, higher risk of vascular events with bevacizumab treatment, and higher plasma VEGFA concentration
25480498 Serum survivin and VEGF expression can predict survival in a nasal type extranodal NK/T-cell lymphoma.
25480334 These findings suggest that increased plasma VEGFA and reduced PLGF correlate with clinical severity of pulmonary vascular disease and may be associated with adverse outcome in CDH.
25470608 a possible coordinated role of VEGF-A and MMP-2 during uterine leiomyomas growth and angiogenesis with potential prognostic significance
25468805 -460TT and -2578AA homozygote of VEGF might lead to significantly increased cancer risk for Asians.
25466960 VEGF is implicated in the pathogenesis of inflammation after electrical burns.
25450973 Placental mesenchymal-like adherent stromal cells -induced neuroprotection in ischemic PC12 cells may be partially explained by IL-6 and VEGF165 secretion.
25450585 VEGF production by peripheral blood mononuclear cells is inhibited during preeclampsia, creating a downregulation of the microenvironment; this deficiency may contribute to the pathogenesis of disease.
25448984 miR-185-mediated Vegfa targeting may be involved in breast cancer formation
25447599 The results of this study that confirming VEGF as useful diagnostic and monitoring marker of POEMS syndrome.
25446246 VEGF-alpha, MMP-2 and MMP-9 may play a role in colorectal tumorigenesis
25444917 Results indicate that CCL5 chemokine promotes vascular endothelial growth factor-dependent angiogenesis in chondrosarcoma cells by downregulating miR-199a.
25428912 miR-126 could suppress tumor growth and tumor angiogenesis of gastric cancer through VEGF-A signaling
25428740 Increased plasma VEGF in aged patients was associated with atherosclerotic aortic valve stenosis.
25425729 VEGF mRNA levels in pleural fluid were significantly higher in all subgroups of malignancy
25423914 Results implicate that VEGF 1451C > T and 1725G > A may predispose to colorectal cancer susceptibility and the genetic contributions may be varied with the presence of metabolic syndrome.
25417698 induced pluripotent stem cell derived human Niemann-Pick type C disease neurons are generated and the abnormalities caused by VEGF/SphK inactivity in these cells are corrected by replenishment of VEGF.
25417001 Plasma levels of VEGF are increased in the stable phase after myocardial infarction and correlate with inflammation cytokines, but not with the atherosclerotic burden.
25414254 In a rabbit model of critical limb ischemia, intramuscular injection of adipocyte stromal cells genetically modified to overexpress VEGF increased angiographically visible collaterals and capillary density.
25412937 The single nucleotide polymorphism +936 C/T VEGF is associated with human epidermal growth factor receptor 2 expression in Moroccan breast cancer women.
25410981 MUC1 and VEGF mRNA positivity in blood seem to be indicators of unfavorable response and poor PFS and OS in patients with advanced NSCLC treated with gefitinib.
25385479 Our findings suggest a cooperative relationship between miR-410 and VEGF in OS cell regulation.
25384022 increased peritoneal expression of connective tissue growth factor (CCN2), transforming growth factor-beta1, and vascular endothelial growth factor in encapsulating peritoneal sclerosis encapsulating peritoneal sclerosis
25379550 VEGF, PDGF, and TGF-beta1 concentrations in platelets may be associated with prognosis of breast cancer.
25374209 High level of serum VEGF is associated with cervical cancer.
25371074 Biglycan up-regulated VEGF expression.
25367856 VEGF expression of hepatocellular carcinoma were correlated inversely with the MRI apparent diffusion coefficient values and the intensity of arterial enhancement in MRI.
25366785 Data show that only tumor-node-metastasis (TNM) stage, metastasis, and the vascular endothelial growth factor (VEGF)-2578 AA and -1154 AA genotypes were independent prognostic factors.
25366387 up-regulated levels in sera of pulmonary sarcoidosis patients
25364078 serum from OSA alters endothelial cell repair function and activates monocyte migration--partly driven by VEGF and CRP, suggesting an unfavorable balance between the pro-healing and pro-injury factors that may promote vascular injury in OSA
25362254 Peripheral artery disease is associated with elevated levels of an antiangiogenic VEGF-A splice isoform (VEGF-A165b) and a corresponding reduction in levels of the proangiogenic VEGF-A165a splice isoform.
25361753 C936T polymorphism of the VEGF gene did not influence the occurrence of sporadic colorectal adenocarcinoma development and did not correlated with the degree of tumor invasion, lymph node involvement and occurrence of metastases.
25361735 investigate cross-talk between VEGF and proinflammatory TNF-alpha signaling in endothelial cells and its impact on leukocyte recruitment
25354293 VEGF/PlGF levels were higher in neonates exposed to pre-eclampsia, and there was a significant negative correlation between birth weight and VEGF/PlGF levels.
25351965 There was no significant difference in serum VEGF between Kawasaki disease patients with or without pericardial effusion.
25341970 A positive correlation was found between VEGF mRNA and miR-126 expression.
25341039 CTGF activates PI3K, AKT, ERK, and NF-kappaB/ELK1 pathway, leading to the upregulation of miR-210, promoting HIF-1alpha-dependent VEGF expression and angiogenesis in human synovial fibroblasts.
25339042 High VEGF expression is associated with malignant pleural effusions in lung cancer.
25337261 pSTAT3-VEGF signaling pathway, which is correlated with peritumoral edema extent, might be a regulatory mechanism in the course of peritumoral edema formation during glioblastoma tumorigenesis and progression.
25337214 VEGF is highly expressed in retinoblastoma and is associated with optic nerve invasion.
25337211 miR-29b may play an important role in osteosarcoma progression by negatively regulating the expression of VEGF, suppressing proliferation and inducing apoptosis.
25335740 For an aggregate result of survival analysis, +936C>T polymorphism was linked to an unfavorable OS (HR=2.248, 95%CI: 1.257-4.017, P=0.006) under homozygous model (TT/CC).
25333935 Primary tumor-derived VEGF might thus be a crucial factor responsible for the formation of the pre-metastatic niche by inducing PGE2 production.
25331892 These results demonstrate that a VEGFR2/NAADP/TPC2/Ca(2+) signaling pathway is critical for VEGF-induced angiogenesis
25329921 The increased VEGF level in vitreous fluid may be identified as a significant predictive factor for the outcome of vitrectomy in patients with PDR.
25329693 VEGF can trigger placental overexpression of soluble FLT1.
25326806 the antiangiogenic effects were substantially enhanced when the agents were combined which may due to the reduced expression of VEGF and matrix metallopeptidase-9 (MMP-9) in tumor tissues
25326706 VEGFA-rs833058CT and rs2146323AA single nucleotide polymorphisms were associated with a significantly increased risk of developing wheezing and recurrent wheezing, respectively.
25320085 Data indicate the regulatioin of vascular endothelial growth factor (VEGF) signaling in Krev-interaction trapped 1 (KRIT1)-depleted endothelial cells.
25308005 this study used immunohistochemical methods to demonstrate the presence of IGF-1, TGF-beta1, and VEGF growth factor receptors in normal, adenomatous, and hyperplastic parathyroid tissue.
25307345 the NTR1-HIF-1alpha-VEGFalpha axis has a role in intestinal angiogenic responses and in the pathophysiology of colitis and inflammatory bowel disease
25304617 High VEGF expression is associated with primary effusion lymphoma.
25301739 Up-regulation of VEGF is associated with chondrosarcoma.
25300614 We consider that in situ hybridization assessment of VEGF for human pterygium specimens can be a useful tool for reconsidering the selection of pterygium patients to be enrolled in anti-VEGF therapy.
25296733 there was positive correlation (p < 0.0001) between those biomarkers and the tumor grades. We also noticed an association between VEGF and IL-8 as well as CRP and IL-6.
25291956 Plasma VEGF levels are significantly associated with vasculitic neuropathy and may be used to predict this disease.
25290554 PI3Kgamma-induced VEGF expression was reduced when the human tocopherol-associated protein 1 (hTAP1/SEC14L2) was overexpressed suggesting formation of an inactive PI3Kgamma/hTAP1 heterodimer
25288151 VEGF-A is involved in CRT-related neuronal differentiation in neuroblastoma.
25286761 In conclusion, we interpret our data to prove that CD105 promotes the invasion and metastases of liver cancer cells by increasing VEGF expression
25283528 In patients with chronic end-stage liver disease and HCC, a pre-LT plasma VEGF level > 44 pg/mL may be a predictor of tumor vascular invasion and recurrence-free post-LT survival.
25280384 Meta-analysis identifies association of rs833061 variant in the VEGFA gene and rs3917887 variant in the CCL2 gene as the most significant association with the risk of diabetic nephropathy.
25274915 The levels of expression of VEGF and syndecan-4 mRNAs were significantly and positively correlated in cartilage explant but not in cultured chondrocytes.
25274272 The carboxyl terminus of VEGF-A is a potential target for anti-angiogenic therapy.
25257525 Cyclic equibiaxial strains of 1% to 16% for 12 h, respectively, induced expression of VEGF in human chondrocytes dose- and frequency-dependently.
25255852 The present results indicate a positive association between VEGF -1154G > A and the risk of developing endometriosis, whereas the CCGG haplotype may be protective against the development of disease.
25250517 Demonstrate that a HR6 scFv selected from human library phage display specifically blocks VEGF signaling to inhibit angiogenesis.
25249155 G-CSF increases MMP-2 activity and VEGF secretion in Swan 71 cells (trophoblasts) through activation of PI3K/Akt and Erk signaling pathways.
25247819 VEGF(+405G>C) impacted fertilization, embryo implantation and pregnancy rates. Combined VEGF+405.GG and TNFalpha-308.AG or AA genotype was associated with high implantation potential; VEGF+405.CC and TNFalpha-308. VEGF+405.CC and TNFalpha-308.GG with low.
25242215 VEGF-A-rich human adenocarcinomas induce tumor lymphangiogenesis via recruitment of lymphangiogenic endothelial progenitor cells from bone marrow.
25240960 analysis of the molecular aspects and function of VEGF and its role in tumorigenesis, inflammation, and their treatment [review]
25234649 PIAS4 (rs735842) and VEGFA (rs699947) were the most statistically significant variants associated in hypoxia pathway analysis.
25231285 Helicobacter pylori induced VEGF production in gastric epithelial cells via both T4SS-dependent and T4SS-independent pathways.
25224594 Alternative splicing of TIA-1 in human colon cancer regulates VEGF isoform expression, angiogenesis, tumour growth and bevacizumab resistance.
25218965 This is the first study investigating an association between BDNF Val66Met and VEGFC2578A and avoidant focused coping strategies in psychiatric patients with suicide attempts.
25218306 These data suggest that VEGF-induced antidepressant-like effects involve modulation of norepinephrine and serotonin systems.
25217793 Polymorphism-460C/T of the VEGF gene was correlated with non-proliferative diabetic retinopathy (NPDR), and C allele was associated with lower NPDR risk than T allele.
25204086 High VEGF levels are associated with gynecologic cancer.
25202119 VEGF showed a trend towards worse LRC and survival, VEGFR-1 towards worse survival. Outcomes were associated with hemoglobin, performance status and tumor stage.
25200689 These findings support the hypothesis that increased levels of the VEGF and sVEGFR-1 and VEGF/SVEGFR-1 ratio may be associated with the pathogenesis of TA [threatened abortion ].
25193461 This study demonstrated that plasma VEGF in patient with major depression disorder higher then normal control.
25192841 VEGF and VEGFR2 expression were increased after low level laser therapy in human adipocyte-derived mesenchymal stem cells.
25191724 Correlation was established between the percentage of the immunoregulatory T-cell subpopulations and VEGF-A expressing in the group of exposed persons.
25186136 Report a significant association between maternal prepregnancy BMI/adiposity and VEGF levels and an inverse correlation between VEGF and PlGF in pregnancy-induced hypertension.
25184149 Our findings suggest that VEGF rs2010963 and rs3025039 polymorphisms may contribute to the risk of DN in DM patients, especially among Asians.
25179090 Increased placental VEGF together with impaired metabolic control may have a role in stimulating foetal overgrowth in type 1 diabetes pregnancy
25176450 Results found that miR-497 expression was downregulated in human ovarian cancer tissues and its low expression was ssociated with increased angiogenesis. Also, mir-497 was found to exert its function of anti-angiogenesis by suppressing VEGFA expression.
25175315 One of the important roles of IFN-b for malignant glioma growth inhibition was anti-angiogenesis by directly inhibiting angiogenesis through downregulation of VEGF and upregulation of IP-10 and indirectly changing the tumor microcirculation
25172656 Ang-2 and VEGF are commonly targeted by miR-351 in hypoxia-induced microvascular retinal dysfunction.
25172294 VEGFA may have a role in esophageal squamous cell carcinoma in high-risk Chinese populations
25162518 RBP2 promotes HIF-1alpha-VEGF-induced angiogenesis of non-small cell lung cancer via the Akt pathway.
25158264 Integrin beta1 and VEGF are overexpressed and microvascular density is increased in hypopharyngeal squamous cell carcinomas.
25157100 VEGF regulates NFATc1 binding to angiogenesis-related genes in the endothelium
25156689 Laboratory findings indicate stabilisation and an increased transcription activity of hypoxia-inducible factor 1 alpha (HIF1alpha), leading to up-regulation of its downstream target genes (such as vascular endothelial growth factor (VEGF).
25152223 The results from univariate and multivariate analyses suggest an influence of VEGF-A gene variants on the development of distant metastases in breast cancer patients.
25150213 results indicate that BDNF increases VEGF expression and enhances angiogenesis through a signal transduction pathway that involves the TrkB receptor, PLCgamma, PKCalpha, and the HIF-1alpha
25148899 Studied the association of four SNPs of VEGF-A, namely: -1154A/G (rs1570360), -2578C/A (rs699947), -634G/C (rs2010963) and -460T/C (rs833061) with breast cancer susceptibility and aggressiveness in Moroccan women.
25140996 We have found significant increased serum levels of VEGF in patients with Graves ophthalmopathy when compared with control group. This difference was unchanged with immunosuppressive therapy.
25139485 VEGFA rs833061 SNP is associated with theobjective response rate
25135429 High VEGFA expresssion is associated with cervical cancer growth and invasion.
25130874 VEGFA -583C > T polymorphism and reduced serum VEGF levels are associated with the susceptibility to acute chest syndrome in pediatric patients with sickle cell disease.
25124076 Our results suggest an association of VEGFA polymorphisms with Kaposi's sarcoma herpesvirus viremia among kidney transplant recipients in this study population.
25123184 Our data suggest that MMP-9 and VEGF are key therapeutic targets of EGCG for treatment and prevention of ocular angiogenic diseases such as age-related macular degeneration, diabetic retinopathy, and corneal neovascularization.
25122063 Data suggest that circulating VEGF increases toward term and significantly decreases at time of labor; chorion appears to be main source of VEGF, expression increases toward term and decreases with onset of labor.
25117453 ZMYND8 induces vegfa mRNA expression selectively in prostate cancer xenografts.
25117311 None of the EGF +61 A>G or VEGF +936 C>T polymorphisms investigated in this study was associated to a genetic predisposition to CRC in the Malaysian population.
25116954 There are antiangiogenic actions of vascular endothelial growth factor-A165b, an inhibitory isoform of vascular endothelial growth factor-A, in human obesity.
25111568 VEGFA rs1570360 GA genotype was significantly over-represented in the CON group
25109477 Nasal lavage VEGF and TNF-alpha levels during a natural cold predict asthma exacerbations.
25108133 Data indicate that age, hypertension, diabetes, dyslipidemia, and hyperhomocysteinemia were aggravating factors for the aortic calcification in association with different vascular endothelial growth factor A (VEGF) genotypes.
25106940 The VEGF +405G/C polymorphism may constitute an inheritable risk factor for PCOS in south Indian women.
25106408 VEGF -152 G/A and -116 G/A polymorphisms were found to be significantly associated with increased risk for breast cancer.
25097078 Studied axillary lymph node (ALN) metastasis of early breast cancers by evaluating the status of DARC, D6 and CCX-CKR and the levels of VEGF and MMP-9.
25092217 Our data present, for the first time, preliminary evidence that VEGF C936T alone or combined with the COL18A1 D104N polymorphism of AG constitutes an important inherited EOC determinant.
25089267 density of lymphangiogenesis and the intensity of the VEGF expression are considered to be an unreliable predictor of melanoma metastasis to the sentinel lymph node
25086956 High VEGF expression also was the independent adverse prognostic factor for embryonal rhabdomyosarcoma (ERMS). Because CXCR4, CXCR7, and VEGF are widely expressed in rhabdomyosarcoma (RMS).
25079441 VEGF -1154 G>A analysis is not reliable in FFPE tissues and that homozygous AA and heterozygous GA genotypes may be over- and under-estimated.
25077433 Sox2 is required for cutaneous squamous cell carcinoma growth in mouse and human, where it enhances Nrp1/Vegf signaling to promote the expansion of tumor initiating cells along the tumor-stroma interface.
25076849 It appears that tumor suppressor gene-VEGF axis have dual role on immune response in inflammation of UC and tumor growth and progression of CRC.
25071074 Expression level of KAI1 was downregulated, while the expression level of VEGF was upregulated in the tissues or serum of patients with hepatocellular carcinoma. Combined detection of KAI1 and VEGF form a reliable panel of diagnostic markers for HCC.
25069421 clear cell renal cell carcinoma VEGF expression is significantly associated with tumor stage and Fuhrman grade
25062489 High platelet and neutrophil counts, low lymphocytes, and VEGF -2578C/A and -1154G/A polymorphisms were shown to be independent factors for a poor prognosis of renal cell carcinoma patients.
25058601 VEGF-mediated, androgen-dependent regulation of angiogenesis is impaired by aging
25050486 Polymorphisms in VEGF gene are risk factors for age-related macular degeneration in the Indian population.
25036364 HIV-1 Tat upregulates VEGFA (VEGF) expression in HUVEC and EA.hy926 cells
25031718 these findings indicate that homeobox A9 regulates the expression of VEGF in epidermal stem cells
25027022 Data showed that in 197 different histological subtypes of pituitary adenomas 58.9% showed VEGF high expression.
25015210 Findings suggest a role for autocrine vascular endothelial growth factor A (VEGF) signaling in the survival of colorectal cancer (CRC) cells to hypoxia and thus to angiogenesis inhibition.
25015036 The loss of membranous E-cadherin with increase in cytoplasmic accumulation in differentiative layers of epithelium through the progression of dysplasia was noted along with up-regulation in VEGF expressions
25012744 The role of the vascular niche and angiogenic factors, particularly VEGFA, during pancreatic beta cell development. [Review]
25010863 Inhibition of SRPK1 by knockdown or with pharmacological inhibitors reduces expression of pro-angiogenic forms of VEGF.
25007988 Role of maternal/fetal VEGF-CT936 polymorphism as a modulating factor in preeclampsia, which affects the angiogenic balance in preeclamptic mothers, as well as their pregnancy outcome.
25007957 Hypoxic stress decreased the miR-9 level in ARPE-19 cells, which increased the transcriptional level of SRPK-1, resulting in alternative splicing shift to pro-angiogenic isoforms of VEGF165 in human retinal pigment epithelial cells.
24998915 The ratio of VEGF/endostatin levels was significantly higher in operable non-small cell lung cancer patients than in normal controls.
24995304 patients with lower Durie-Salmon stage had significantly lower OPN and VEGF levels (P = 0.05; P = 0.04, resp.). Our preliminary results found positive association between plasma level of OPN, tumor burden, and bone destruction
24995287 both VEGF and PDGF were significantly downregulated after completing a full CMP rush IgE desensitization.
24989926 Our study suggests that VEGF-2578C/A and VEGF-634G/C polymorphisms may have effects on the prognosis of renal cell carcinoma
24987682 study demonstrated that AuNPs significantly inhibited VEGF165-induced HUVEC migration and tube formation by affecting the cell surface ultrastructure, cytoskeleton and might have inhibited angiogenesis via the Akt pathway.
24986100 EZH2 correlates positively with VEGF and associates with adverse clinicopathologic characteristics and shorter survival time in clear cell renal cell carcinoma patients
24982443 homophilic fibronectin binding peptides might have novel applications in the field of tissue regeneration as tools to regulate neovascularization via VEGF signaling
24980036 study indicates HIF-1 not only regulates hypoxia-induced VEGF-A production but also mediates at least in part the effects of growth factors and dexamethasone on VEGF-A synthesis and release; findings show the complexity of VEGF-A regulation in meningiomas
24971768 Results suggest that VEGFA is associated with chronic mountain sickness in long-term residents at high altitude in the Peruvian Andes.
24971577 VEGFA ACG+/+ genotype confers an adverse effect in overall survival in chronic lymphocytic leukemia patients with an indolent course of the disease.
24969882 The serum VEGF, SIL-2R and HGF contents in 81 patients.
24966925 Rg3 exhibits anti-leukemia effect in part due to its anti-angiogenic activity via inhibiting PI3K/Akt and ERK1/2 pathways, which act to regulate the expression of HIF-1alpha and VEGF.
24966171 VEGF-A stimulates signal transduction pathways that modulate endothelial outputs such as cell migration, proliferation, tubulogenesis, and cell-cell interactions.
24965046 this undesirable interaction with tyrosine kinase inhibitors can be avoided by using anti-angiogenic drugs that spare the VEGFR2 pathway.
24959596 The developed hypoxic state may upregulate the synthesis of VEGF and thereby eNOS. Increased expression of VEGF and eNOS in severe group may be a compensatory mechanism to dilate the blood vessels and to improve blood flow of fetus.
24949972 Study shows that VEGFA mRNA in mammalian endothelial cells undergoes programmed translational readthrough (PTR) generating VEGF-Ax, an isoform containing a unique 22-amino-acid C terminus extension. VEGF-Ax was detected in tissue slices from human brain, colon, small intestine, spleen, and pancreas and from serum from healthy human subjects.
24949865 expression of VEGF and Dll4/Notch pathway molecules in ovarian cancer
24948534 Exogenous Abetas stimulate the normal cortical adult astrocytes to produce and secrete VEGF-A through a CaSR-mediated mechanism. Abetas in the AD brain may make astrocytes into multi-agent AD-driving "machines" via a CaSR signaling mechanism(s).
24945674 The genetic polymorphisms of EGF:rs4444903, EGF:rs2237051 and VEGF:rs2010963 showed significant associations with overall survival (OS) of advanced esophageal squamous cell carcinoma patients.
24940033 These findings indicate that VEGF-A(165)b inhibits TNF-alpha-mediated upregulation of ICAM-1 expression and increases monocyte-retinal pigment epithelial cell adhesion.
24935327 results suggest that patients carrying a combination of SNPs for TNF-alpha, VEGF-A, and IL-17F of ACGTCT haplotype may have an increased risk of corneal allograft rejection compared with patients carrying other haplotypes
24931695 quindoline derivatives can interact with the G-rich DNA sequences of the VEGF promoter to stabilize this G-quadruplex and suppress the transcription and expression of the VEGF protein.
24928387 These results reveal that paracrine factors secreted by meningothelial cells can influence migration and adherence of medulloblastoma tumor cells, but VEGFA may not be a specific target for therapeutic intervention in this context
24916146 Dickkopf-1 expression was correlated with decreased microvessel density (P < 0.05) and VEGF expression.
24913710 Studies suggest that vascular endothelial growth factor (VEGF) expression may be strongly correlated with pathological characteristics of diffuse large B cell lymphoma (DLBCL).
24907654 And increased VEGF uptake.
24905841 Enhancing medulloblastomas exhibited strong VEGFR1/2 expression relative to nonenhancing tumors.
24903995 The concentrations of VEGF-A and its receptors 1 and 2 in patients with well-controlled diabetes are comparable to those of healthy individuals, which may indicate that appropriate control of glucose levels delays occurrence of vascular complications.
24902660 genetic polymorphism is associated with increased risk of basal cell carcinoma in Polish population
24901151 Studied the effects of Resveratrol (Res) on expression of VEGF gene in human hepatocarcinoma cell line.
24893038 these findings indicate that carbon ion may be superior to X-ray radiation for inhibiting tumorigenesis and angiogenesis through modulation of VEGF level in the glioma microenvironment.
24878611 Depending on the pathological context, activation of HIF-alpha and VEGF-A signaling in renal tissue/cells may have either beneficial or harmful effects.
24868559 genetic association studies: Data suggest that genetic polymorphisms in VEGFA (SNP +936C/T, rs3025039, especially in Asian populations; -SNP 460T/C, rs833061) are associated with genetic predisposition to diabetic retinopathy. [META-ANALYSIS; REVIEW]
24861949 Il-6, IL-17, TNF-alpha and VEGF levels were measured in exhaled breath condensate and serum of 15 patients with stage I-IIA non-small cell lung cancer.
24855100 This study demonstrates for the first time the requirement of HIF1 for FSH-regulated Vegfa expression in vivo and that HIF1 acts via a single hypoxia response element in the Vegfa promoter to exert its regulatory functions.
24851136 Polymorphisms in the VEGFR2 gene and in the VEGF gene are associated with the occurrence of ovarian hyperstimulation syndrome.
24849467 Autocrine vascular endothelial growth factor signaling promotes cell proliferation and modulates sorafenib treatment efficacy in hepatocellular carcinoma.
24845858 This study demonstrated that a significant reduction in vascular endothelial growth factor expression in the superior temporal, hippocampal, and brainstem regions in Alzheimer disease.
24845798 The expressions of VEGF-A, VEGFR2 and VEGFR3 were studied in by immunohistochemistry in 76 endometrial carcinoma specimens. VEGFR2 and VEGFR3 receptor expression were also studied by qRT-PCR in 17 tumors in comparison to normal endometrium.
24845415 no role in endometriosis detected
24839224 These findings provide new information on the role of non-beta cell-derived VEGF-A to IPC regeneration and insulin production.
24837366 demonstrate that ShcA-dependent activation of AKT, but not the RAS/MAPK pathway, induces VEGF production by bolstering VEGF mRNA translation
24833243 Serum VEGF levels were significantly higher in oral cancer patients (p<0.0001) as compared to normal controls
24825110 This study demonstrated increased VEGF expression in human conjunctival and orbital EMZL compared with that in RLH, suggesting that VEGF plays a significant role in the pathogenesis and tumor angiogenesis of ocular adnexal lymphoma.
24821582 CA9 levels increase with VEGF-targeted therapy in metastatic renal cell carcinoma.
24816918 suggests that the -634G/C polymorphism of VEGF does not appear to represent a risk factor for breast cancer
24815691 the role of MiR-718 in the regulation of VEGF in ovarian cancer
24815480 serum VEGF-A level may be a useful biomarker for the prediction of response to therapy in squamous cell carcinoma of head and neck
24815448 VEGF as a candidate for anti-angiogenic targeted therapy was correlated with the development and progression of Neuroblastoma; therefore, VEGF along with Ki-67 can serve as a valuable marker for the prognosis of this tumor type.
24811984 After cardiac surgery, infants who are homozygous for the high-risk alleles for both the VEGFA and SOD2 SNPs have an approximately 16-fold increased risk of death or heart transplant
24810959 High expression of VEGF causes increased angiogenesis in Ewing Sarcoma.
24809949 High VEGF-A expression is associated with drug resistance in colorectal carcinoma.
24803491 Low spermatogenic efficiency of testicular germ cells can be improved by the addition of Matrigel and VEGF165 to the grafted cell suspension.
24801045 suggest that first pregnancy characteristics may exert an influence on extent of breast density later in life and that this influence may vary depending on inherited IGFR1 and vegf genotype
24793809 The expression of VEGF is increased in lung cancer cells following nicotine-induced cell proliferation.
24786777 Logistic regression analysis demonstrated that VEGF-A and Ang-2 levels were associated with psychosocial stress but not with hypertensive status in South Africans.
24783213 Heterotopic bone was engineered in vivo around vessels using different rhBMP-2 and TG-VEGF ratios in a fibrin matrix injected into a dimensionally stable membrane tube which prevented direct contact with skeletal muscles.
24782650 The mRNA expression level of TLR8 in the patients with cervical cancer and Hela cells were up-regulated, it consistent with the increased expression of VEGF and Bcl-2.
24781730 Endothelial cells from aging individuals have impaired angiogenesis and reduced expression of VEGF likely due to impaired nuclear transport of P-STAT3 and P-CREB transcription factors in these cells.
24780459 Vascular endothelial growth factor-A maintains glomerular endothelium viability but causes endothelial cell pathology when generated at too high a level in diabetic nephropathy.
24780003 Current study successfully detected the VEGF expression in HT29 colorectal cancer xenografts, signifying as a potential agent for non-invasive imaging of VEGF expression, which may be applied in clinical practice
24777200 mechanism of how miR-410 targets VEGFA
24772969 body weight, triglyceride, angiogenic growth factors and NO might associate with preeclampsia development
24771685 structural features of VEGF-A involved in neuropilin-1 binding and functional activity
24766673 TFAP2B overexpression contributes to tumor growth and a poor prognosis of human lung adenocarcinoma through modulation of ERK and VEGF/PEDF signaling.
24766213 For the first time, we demonstrate VEGFA expression in mycosis fungoides cells, suggesting that the VEGF pathway may be implicated in the pathogenesis of this disease
24764339 Three-dimensional contrast-enhanced sonographic characteristics were statistically different between benign and malignant breast lesions.
24754736 analysis of how VEGF, VEGFR3, and PDGFRB protein expression is influenced by RAS mutations in medullary thyroid carcinoma
24751925 the association between the VEGF -2578C/A polymorphism and diabetic retinopathy, but not in the Caucasian population (Meta-Analysis)
24748065 There is an increased risk of arteriovenous fistula thrombosis in individuals carrying the VEGF-936C/C genotype.
24746698 Results show that VEGF activates unfolded protein response mediators through a PLCgamma-mediated crosstalk with the mTORC1 complex without accumulation of unfolded proteins in the ER.
24738074 in B1647 leukemia cells, VEGFR-2 is present in caveolae through association with Cav-1, demonstrating that caveolae/lipid rafts act as platforms for negative modulation of VEGF redox signal transduction cascades
24737780 These results suggest that AGM cooperates with VEGF to induce the aberrant functions of cancer vasculature as a ligand of integrin alpha5beta3.
24732642 NF-kappaB expression in tumor tissue is associated with poor survival in gastric cancer patients.
24718046 the presented study, the VEGFA mRNA and protein expression levels were significantly higher in the major depressive disorder. patients
24717944 increased expression in the nasal mucosa of patients with allergic rhinitis
24716659 Overexpression of RBP2 and activation of VEGF might play important roles in human gastric cancer development and progression
24715163 This study analyzes the microvascular density (MVD) for CD105+ and alpha-SMA+ vessels and VEGF immunoexpression for 35 oral squamous cell carcinomas and for the associated dysplastic lesions of the lips.
24710630 The serum levels of IL-27 were remarkably higher in ankylosing spondylitis patients than healthy groups and significantly correlated with serum levels of VEGF.
24710173 brivanib decreased proliferation of HSCs induced by platelet-derived growth factor (PDGF), VEGF, and FGF.
24703319 expression of angiogenic VEGF-Axxxa isoforms was associated with adverse prognosis in the absence of bevacizumab and with favorable outcome when bevacizumab was administered in patients with advanced breast cancer.
24689893 this meta-analysis suggests that the VEGF polymorphisms may be associated with risk of AMD, particularly wet AMD
24687553 CEUS is recommended in evaluating the microcirculation of thyroid cancer in women with breast cancer and has the significant relationship with MVD counts and VEGF expression
24687551 Hepatocellular carcinoma-VEGF score could replace AFP in HCC screening and follow up of cirrhotic patients.
24687381 VEGF -2578CC, VEGF -2578CC plus VEGF -634GG, and VEGF -2578CC plus VEGF -1154GG plus VEGF -634GG genotypes were more frequent in multiple myeloma patients than in controls. Carriers had a 1.89-, a 5.52-, and a 4.91-fold increased risk, respectively.
24678886 Single-nucleotide polymorphism markers at +405C>G, -460C>T, and -1154G>A of the VEGF gene may serve as biological markers of psoriasis.
24677103 VEGF-A signaling in UM cells neither acts retroactively on VEGF-A expression, in the sense of a feedback loop, nor contributes to a pro-angiogenic shift of the VEGF-A/PEDF ratio.
24676933 It might be involved in the pathophysiology of colorectal cancer, and its detection in serum may be useful in classifying the cancer.
24675699 VEGF-A, VEGFR-1, and VEGFR-2 were shown to be up-regulated in malignant Pheochromocytoma, suggesting that these molecules might be considered as therapeutic targets for unresectable or metastatic tumors.
24673399 possible correlation of G-1154A polymorphism with treatment outcome in glomerulonephritis
24671265 EG-VEGF and VEGFA systems shared several canonical signaling pathways that may contribute to gene-gene interactions, including the Akt, IL-8, EGFR, MAPK, SRC, VHL, HIF-1A and STAT3.
24670538 There were significant positive associations between COX-2, MMP-9 and VEGF expression and age (>45 years), clinical stage (III-IV) and tumor diameter.
24668884 15-LO1 is able to promote HIF-1alpha turnover and to suppress VEGF expression in cultured cells based on forced stable overexpression or transient transfection, whereas 15-LO1 inhibition reverses above effects
24668662 We conclude that Ad-VEGF165 promotes neovasculization in ischemic limbs. Embolus-carried Ad- VEGF165 had the most pronounced effect.
24666229 Data suggest that IL-4, IL-15, and VEGF, may play roles in the pathogenesis of myasthenia gravis (MG).
24664750 RT-PCR for HIF-1alpha and VEGF and ELISA for VEGF indicated that high glucose is associated with elevated production of HIF-1alpha-induced VEGF, an established inducer of neovascularization, in the retinal pigment epithelial cells.
24664708 Here we discuss recent findings from our lab and others that define roles of the HIF-VEGF axis in the retina.
24662923 In conclusion, polymorphism VEGF -634C > G may influence the risk of bronchopulmonary dysplasia .
24660027 HIV-1 Tat upregulates VEGFA (VEGF) expression in HUVEC and EA.hy926 cells
24659092 the relationship between breast cancer ultrasound synthesis diagnostic index (SDI) and the expression of MVD, VEGF and HIF-1alpha
24657063 This study identifies polymorphisms in the HIF1A and VEGF genes as potential genetic markers that indicate the predisposition to either AAA coexisting with peripheral atherosclerosis or AAA without such lesions.
24652518 no pharmacogenetic associations exist between the studied VEGFA and VEGFR2 SNPs and response to anti-VEGF therapy.
24651981 High VEGF gene expression levels were associated with lymph node metastases in advanced gastric cancer.
24641672 VEGF isoforms activate FLK1-neuropilin-1 signaling in lung cells leading to inhibition of epithelial cell apoptosis.
24636631 The role for circulating serum VEGF in depression. Furthermore, our data also demonstrate that other factors than a diagnosis of depression influence the serum VEGF level
24632679 Dynamic monitoring of nitric oxide and ANG II, along with VEGF, may not be useful as predictive markers for bevacizumab treatment in colorectal cancer.
24627040 Data demonstrate that downregulation of VEGF expression attenuates malignant biological behavior of C6GSCs.
24626176 Loss of even a single conditional VEGF allele results in substantial rescue from endothelial cell transformation.
24623035 High serum levels of vascular endothelial growth factor-A is associated with low response to therapy in esophageal squamous cell carcinoma
24615084 NGF regulates the expression of VEGF through the PI3K/mTOR signaling pathway in human HaCaT keratinocytes.
24612214 Concomitant upregulation of PDGF-C with VEGF in Glioblastoma tumor cells.
24607779 VEGF may promote vascular health by decreasing ET-1 production.
24607726 The VEGF + 936 T allele is associated with the susceptibility to vasculitis in Europeans, but not in Asians.
24606881 The findings demonstrate an endothelial VEGF resistance mechanism conferred by palmitic acid, which comprises ceramide-induced, PP2A-mediated dephosphorylation of critical activation sites on enzymes central to vascular homeostasis and angiogenesis.
24603119 Report role of vitronectin in the regulation of angiogenesis induced by VEGF.
24601908 We review and discuss here what it is currently known in regard to the role of VEGF in CM as well as VEGF as a potential biomarker.
24598169 the detection of CD163+ macrophages and pro-angiogenic factors IL-8 and VEGF reflects the local environmental status of host immunity and can be helpful for diagnosis of cancerous inflammation in the lungs
24587407 Data indicate that silencing of alpha-fetoprotein led to an increased apoptosis, which was associated with a decreased expression of vascular endothelial growth factor, vascular endothelial growth factor receptor 2, matrix metalloproteinases-2/9.
24586790 VEGF is also neurotrophic.
24577893 VEGF and MMP3 may have a potential role in the pathogenesis of oral squamous cell carcinoma.
24577260 Overexpression of the VEGF gene in subjects with daily urinary protein excretion 5 g may point to insufficient oxygen supply in renal
24561239 VEGF induced cancer cell motility is blocked by inhibitors of AKT phosphorylation.
24551192 HIV-1 Tat upregulates VEGFA (VEGF) expression in HUVEC and EA.hy926 cells
24551038 Exogenous application of VEGF can increase the permeability of the blood brain barrier without causing brain edema.
24534755 The risk alleles A in IL-8 rs4073, A in VEGF rs699947, and C in CFH rs1061170 had a marked cumulative effect on the presence of intra- or subretinal fluid.
24534217 Our study indicated that DR patients have higher VEGF levels than diabetic patients without retinopathy, and -2578A/C (rs699947) and +405C/G (rs2010963) may be important factors in determining serum VEGF levels.
24528036 The findings of the present study indicated significant associations of VEGF +936C>T and +405C>G polymorphisms with increased breast cancer risk in patients from Punjab, North India.
24522370 Polymorphisms of VEGF A seem to influence the different response to antiangiogenic treatment in patients with age-related macular degeneration in our population.
24515658 this meta-analysis suggests that VEGF expression has an important impact on overall survival in patients with osteosarcoma
24511001 FGF9 can be associated with epithelial-to-mesenchymal transition and invasion by inducing VEGF-A expression in prostate cancer cells.
24510998 Findings provide the novel insight that HIF-1alpha-dependent VEGF overexpression under hypoxic conditions shows to some extent associations with the metastatic tendency of ACC cells.
24507679 Relationship between VEGF, P53 and telomerase expression and their influence on angiogenesis in gastric carcinoma tissue was analyzed. Microvascular density (MVD) and the expression of VEGF, P53 and telomerase were positively correlated.
24505095 ACE(rs4646994)-D allele alone and in the presence of VEGF(rs2010963)-G allele can be an important independent risk factor for susceptibility of coronary artery disease in II diabetes mellitus patients.
24502825 Polymorphic genotype and the A allele in cases with diabetic retinopathy compared to the control group, there might be no significant association between the VEGF gene polymorphism and DR per se, unless it is longstanding.
24501421 Shedding of VEGF-165 from the cell surface together with other membrane components appears to be a unique feature by which some VEGF is delivered to the surroundings to exert its known biological actions.
24491896 The role of vascular endothelial growth factor in pathogenesis of immunological and inflammatory diseases, including allergy, asthma and different skin disorders has been indicated.
24491241 VEGF-A is specifically elevated in both serous cystic neoplasms cyst fluid and lesion tissue.
24485669 serum level significantly decreased in pre-eclampsia relative to controls
24484391 plasma level significantly elevated in intrauterine growth restriction
24480377 VEGF expression in pancreatic adenocarcinoma was associated with angiogenesis as measured by microvessel density.
24480048 TXS overexpression was also associated with higher levels of VEGF, microvessel density, and reduced apoptosis in xenograft tumors
24474253 the subgroup analysis of recessive model indicates that VEGF +405G/C polymorphisms increase the risk for colorectal cancer
24473118 results reveal an interplay between melanoma cells and EC mediated by ET-1 and VEGF-A/-C and coordinated by the hypoxic microenvironment through HIF-1alpha/2alpha transcriptional programs
24471989 The reduced expression of COX-2 and VEGF in the endometrium of women with endometrial polyps (EP) may account for the association between EP and infertility.
24471417 The analysis of the VEGF promoter variation, known as the susceptibility/modifier factor, showed a segregation of the haplotype CA/AG (-2578C/A; -1190A/G) in patients developing ALS related to pregnancy.
24464787 The oncoprotein HBXIP enhances angiogenesis and growth of breast cancer through modulating FGF8 and VEGF.
24463275 The comparison between the cytokine profiles of ET and PV patients showed a statistically significant increase of IL-4, IL-8, GM-CSF, interferon -gamma, MCP-1, PDGF-BB, and VEGF in the ET group
24450403 during muscle activity, these VEGF-containing vesicles are redistributed toward the sarcolemma where the contents are secreted into the extracellular fluid.
24449824 ERG1 is aberrantly expressed in human gastric cancer since its early stages and drives an intracellular pathway leading to VEGF-A secretion
24448750 Urothelial bladder carcinoma displayed elevated expression for cyclin D1, VEGFA and TGFbeta1.
24448601 serum interleukin (IL)-27 and VEGF levels are associated with the clinical stage of breast cancer.
24443223 TGFb1 rs1800469 C>T polymorphism was significantly associated with decreased risk of conotruncal heart defects. TGFbetaR2 and VEGF polymorphisms may not play a role in the susceptibility of conotruncal heart defects.
24441220 VEGF expression correlated with the microvascular density in meningioma irrespective of tumor grade.
24439853 This review finds no evidence that VEGF polymorphisms are not associated with severity of coronary artery disease.
24435801 Our findings indicate that the VEGF-A ATTGC haplotype may predict clinical recurrence in prostate cancer patients treated with radiotherapy.
24410720 PLGF and VEGF-A have distinct patterns of expression in vascular cells.
24403492 High serum VEGFA expression is associated with early recurrence in cervical cancer.
24403062 These findings strongly support a role for PTP4A3 as an important contributor to endothelial cell function and as a multimodal target for cancer therapy and mitigating VEGF-regulated angiogenesis.
24402435 Inhibition of PGC-1A suppresses cell proliferation probably by downregulation of VEGF and GLUT-4.
24401996 The promoter containing the -1,498T/-634C haplotype exhibited the highest basal promoter activity and is involved in breast cancer aggressiveness.
24401755 results of our study showed that high LDH5 and VEGF expression in both tumor and stroma was a prognostic factor for patients with gastric cancers, especially diffuse- or mixed-type cancers
24401189 This study is the first to demonstrate a direct association between VEGF levels and a dimension of the TCI in healthy subjects.
24400721 Studies indicated that VEGF (vascular endothelial growth factor), VEGF-inactivating sFlt-1 (soluble fms-like tyrosine kinase-1) and AT1 (angiotensin II type 1) receptor were involved in pre-eclampsia.
24398760 data suggest that VEGF and MMP-9 play an important role in the malignant behaviour of gliomas
24398102 elevated extracellular concentration of ONOO- produces an upregulation of the angiogenic factors VEGF, hypoxic-inducible factor-alpha (HIF-1alpha), and BFGF in a human corneal limbal epithelial (HCLE) cell line.
24392031 vitreous levels of matrix metalloproteinases and vascular endothelial growth factor in proliferative diabetic retinopathy
24390792 We found that vasohibin-1 and VEGF are up-regulated, in mesentery and liver, in cirrhotic and precirrhotic portal hypertensive rats and cirrhosis patients.
24390659 the results of our meta-analysis suggest that the VEGF +936C/T polymorphism is significantly associated with breast cancer development
24376787 VEGF gene polymorphisms in diabetic retinopathy
24370903 High serum VEGFA levels are associated with gastric and gastroesophageal junction cancers.
24370784 MiR-34a is frequently downregulated in colorectal cancer and modulates the phosphorylation of FAK by negatively regulating VEGF.
24366206 MIF and VEGF play an important role in the progression of hepatocellular carcinoma.
24356758 At 6-8 weeks after birth, blood IGF-1 and VEGF levels are not significantly different between premature infants with proliferative retinopathy of prematurity and those without
24356493 role in normal lung maintenance and in the development of lung injury [review]
24354513 overexpression may play important role in the development of cutaneous squamous cell carcinoma
24354491 Decreased expressions of SDF-1alpha/CXCR4 and VEGF in the placental bed could be associated with the pathogenesis of pre-eclampsia.
24353087 current data suggest that the VEGF rs833061, rs3025039, and rs2010963 polymorphisms are not obviously associated with risk of prostate cancer.
24347177 The expression of vascular endothelial growth factor (VEGF), matrix metalloproteinase 2 (MMP2), tissue inhibitor of metalloproteinase 1 (TIMP1), interleukin 6 (IL-6), and interleukin 15 (IL-15).
24347168 endoplasmic reticulum stress potentiated HIF-1 activity to transactivate VEGF expression as well as another well characterized target, BNIP3.
24341227 The expression of VEGF and its receptors was ascertained to be increased in the placental terminal and stem villi, mostly in type 1 diabetes.
24338338 survivin and VEGF are over-expressed in small-cell lung cancer and may have a role in tumorigenesis
24332926 We propose that gradients are formed through degradation of sequestered VEGF[review]
24330824 increased RUNX2 and VEGFA gene copy numbers and elevation of their respective proteins in human OS
24330582 Results show that AhR induces VEGF expression in HepG2 cells under glucose deprivation, through a pathway involving ATF4.
24322015 Angiogenesis evaluated through the VEGF and MVD (CD105+ and alpha-SMA+) expression is correlated with the progression and metastasis of gastric cancer and could be considered a prognostic marker of these tumors.
24321896 Genotypes for VEGFA polymorphisms can be useful to help to identify hypertensive patients at greater intrinsic risk for heart failure.
24310504 VEGF genetic variants are potentially related to Osteosarcoma susceptibility in Chinese Han population.
24305433 these results show that VEGF binds to matrix molecules in proximity of HUVECs in Matrigel, and suggest that bound VEGF drives vascular network patterning.
24304382 In transgenic mice, VEGFA up-regulation was observed in the injuried nerves which caused neuropathic pain.
24303885 decreased expression of VEGFR1 in decidua and weaker VEGF and VEGFR2 expression in placental villi and decidua may be associated with early pregnancy loss.
24303777 No association was found to support the role for the rs833069, rs943080 and rs4711751 variants of or near VEGFA gene in susceptibility to either PCV or neovascular AMD in Han Chinese population.
24297386 it was observed that SiHa and HeLa cells exhibit depressed proliferation levels following the knockdown of iNOS with a lentivirus. In addition, NO levels demonstrated a correlation with VEGF levels in the cell culture supernatant.
24296159 VEGF165 / VEGFR-2 have roles beyond angiogenesis in hair follicle regulation
24294378 HIF-1alpha and VEGF expression was dependent on the thrombus remodeling stage in cases of intravascular papillary endothelial hyperplasia.
24292799 VEGF level neither correlated with the severity nor with the neurological involvement in dengue patients.
24284961 Apurinic/apyrimidinic endonuclease-1 is overexpressed and associated with cyclooxygenase-2 expression and Vvascular endothelial growth factor production in esophageal cancer tissues
24279470 Our data suggest that high ferritin levels in T2DM are closely related to the development of diabetic vascular complications through interaction with VEGF.
24275556 Data suggest that endothelin-1 and endothelin-1 receptor type B are involved in obstructive sleep apnea syndrome patients circulating VEGF carrying microparticles-induced angiogenesis.
24274376 The VEGF heparin binding site is composed of two basic clusters consisting of side chains of residues R13, R14, and K15 and residues K30, R35, and R49.
24263190 VEGF-mediated signalling occurs in tumor cells, and this signalling contributes to key aspects of tumorigenesis. [Review]
24254563 Higher baseline TIE-2 and VEGF levels are related and worsen survival in cancer patients
24251624 Ischemic neurons activate astrocytes to increase VEGF production, which induces endothelial barrier disruption.
24241899 Both galectin-1 and VEGF can serve as independent prognostic indicators of poor survival for gastric cancer
24240584 Inheritance of genotype -2578 A/A of VEGF gene may modify the PCa susceptibility in Mexican population, providing a protective effect for the disease up to 84%.
24234334 VEGF-A overexpression indicates a poor prognosis for overall survival and disease-free survival in patients with gastric cancer.
24234040 TNF-alpha and VEGF increase with onset of labor and differentially expressed in the RZ and the MZ.
24228111 GnRH-II significantly inhibited the cell proliferation, induced cell apoptosis and decreased the VEGF secreting of endometrial stromal cells from patients with endometriosis.
24227910 VEGF-A, Otx2 homeobox and p53 family genes are expressed in proliferative vitreoretinopathy
24227191 VEGF and PlGF regulate transcription of KCC3b and KCC4 in erythroid cells via activation of HIF-1alpha, independent of hypoxia.
24225154 VEGF expression is increased by bradykinin, which results in increased angiogenesis in prostate cancer cells.
24223772 VEGF -2578C/A or -1154G/A polymorphism had no association with preeclampsia risk, whereas there was an association between VEGF +936C/T or -634G/C polymorphism and risk of preeclampsia. (Meta-analysis)
24222145 High VEGF expression is associated with low response to sunitinib in metastatic clear cell renal cell carcinoma.
24205206 By targeting VEGF-VEGFR2 pathway.
24189120 endothelial progenitor cells involved in the angiogenesis might be controlled by VEGF-PKD1-HDAC7 axis, which regulates the EPCs angiogenesis by PKD1, but not the ERK and PI3K pathway
24185122 results indicate that VEGF-A is highly expressed in GBC and correlates with poor prognosis, suggesting that VEGF-A expression could be used as a biomarker for predicting malignant behavior
24180592 alpha6beta4 integrin and c-Src activation is important early signaling events to lead mTOR activation and cap-dependent translation of VEGF.
24168783 An increase of VEGF after percutaneous coronary intervention is associated with a dramatically increased restenosis rate after implantation of drug-eluting stents.
24165149 No significant association between CD34 Chalkley counts and VEGF expression and disease-specific survival was observed.
24158524 siRNA cocktail, and co-downregulation of VEGF and HER2 result in significant inhibition of gastric cancer growth and migration in vitro
24157918 We showed a significant correlation between VEGF gene polymorphism and treatment outcome in neovascular age-related macular degeneration, with the risk allele carrying a better functional prognosis.
24155658 The pathogenesis of pulmonary emphysema is likely to be multifaceted, but the present mouse model may be useful in dissecting the involvement of VEGF in pulmonary emphysema.
24152156 VEGF gene variants are associated with lung function at school age, but not at birth, suggesting a role of VEGF in post-natal lung function development.
24150126 These results may implicate an additional therapeutic role for anti-VEGF-A when combined with chemotherapy.
24146275 the variant genotypes of the VEGF -2578C/A polymorphism, but not the VEGF -634G/C polymorphism, was associated with lung cancer risk.
24145997 High VEGFA gene expression is associated with early-stage non-small cell lung cancer.
24134622 Low hypoxia in combination with leptin and VEGF regulates the differentiation potential of human adipose tissue-derived stem cells toward endothelial cells.
24131746 Our meta-analysis confirmed the significant association between rs699947 polymorphism and Diabetic Retinopathy (DR) after exclusion of outliers, and rs2010963 polymorphism might be not associated with DR.
24129914 The rhKal also suppressed the VEGF-induced migration and tube formation of HUVECs.
24127038 there is limited evidence for the associations of VEGF 1154G/A and 2578C/A polymorphisms with prostate cancer risk, and more studies are needed to further assess the associations above
24125722 VEGF111b is a novel potent anti-angiogenic agent that can target the VEGF-R2 and its signaling pathway to inhibit ovarian tumor growth.
24123908 We suggest that VEGF could be used as a target for pterygium therapy in patients with the 936C>T genotype.
24123039 Single nucleotide polymorphisms in VEGFA are associated with treatment failure in sunitinib treated gastric and biliary tract cancer patients.
24120473 Neoplastic and non-neoplastic Barrett's epithelial cells have autocrine VEGF signaling. In neoplastic Barrett's cells, VEGF activation of VEGFR2 initiates a PLCG1-protein kinase C-ERK pathway that promotes proliferation.
24114822 Serum VEGF level was an independent predictor of survival in advanced hepatocellular carcinoma, and provided more survival homogeneity within the advanced stages of conventional staging systems.
24114327 Data indicate that the IL-32beta-VEGF-STAT3 pathway affects the migration of MDA-MB-231 cells.
24114200 VEGFA amplification is commonly observed across several tumour entities.
24102466 Induction of the pro-remodeling cytokine VEGF from the airway epithelium is one potential mechanism by which urban particulate matter may influence lung function growth in children irrespective of asthma status.
24098721 High levels and over expression of sFlt-1 and VEGF might be associated with the pathogenesis of recurrent spontaneous abortion.
24098368 common vascular endothelial growth factor polymorphisms (-2578C>A, -460C>T, +936C>T, and +405G>C) in susceptibility to lung cancer
24098328 role of VEGF in adipose tissue-derived stem cell proliferation
24097868 Ang-2-VEGF-A CrossMab treatment led to a strong inhibition of angiogenesis and an enhanced vessel maturation phenotype
24097299 These results suggest that TRAIL inhibits VEGF-induced angiogenesis by increasing caspase-8 activity and subsequently decreasing non-apoptotic signaling functions of procaspase-8, without inducing caspase-3 activation and endothelial cell cytotoxicity.
24083740 High serum VEGF levels are associated with advanced stages of non-small cell lung cancer.
24080590 HTRA1 gene polymorphism may influence patient response to treatment with intravitreal ranibizumab for neovascular age-related macular degeneration.
24067461 The H. pylori-derived peptide Hp(2-20) stimulated eosinophil migration through the engagement of FPR2 and FPR3, and also induced production of VEGF-A and TGF-beta, two key mediators of tissue remodelling.
24057180 This meta-analysis was conducted for deriving a more precise estimation of association between VEGF polymorphisms and the risk of head and neck cancer.
24052076 TG2 inhibition results in inhibition of fibronectin deposition in human umbilical vein endothelial cell monocultures with a parallel reduction in matrix-bound VEGFA.
24048796 The assessment of baseline plasma VEGF levels increases the precision of the CLIP scoring system for predicting HCC prognosis.
24043765 These experiments define a novel VEGF-miR-1-Mpl-P-selectin effector pathway in lung Th2 inflammation and herald the utility of miR-1 and Mpl as potential therapeutic targets for asthma.
24030704 In addition to reconciling the clinical experience with these agents versus their broad activity in preclinical models, these findings may help to select solid tumor types with intrinsic sensitivity to a VEGF vascular-directed therapies.
24024441 The expressions of PD-ECGF and VEGF are higher in the colorectal carcinoma patients with schistosomiasis than in the colorectal carcinoma patients without schistosomiasis.
24023389 Platelet factor 4 has significant crosstalk with vascular endothelial growth factor by modulating cell migration and signal transduction pathways.
24023033 Bone morphogenetic protein 7 increased vascular endothelial growth factor-a expression in human granulosa cells and VEGF receptor expression in endothelial cells to stimulate angiogenesis.
24021586 different species of OxPLs, which are present in the human eye are capable of stimulating expression of VEGF in fetal and primary RPE cells via ATF4-dependent mechanisms.
24021340 Transcription levels of VEGF and endostatin by RT-PCR may be an adjunct to cytology screening for early detection of cervical carcinomas and may determine the progressive potentiality of individual lesions, especially in high-risk patients.
24018375 Overexpression of VEGF-A promotes not only the endothelial specification but also engraftment, proliferation and survival (reduced apoptosis) of the human Isl1+ progenitors in vivo.
24016866 Decorin may interfere with angiogenesis by downregulating hypoxia-induced Met, Rac1, HIF-1alpha and VEGF expression in RPE cells, which suggests a potential strategy for the inhibition of CNV.
24014104 SDF-1 restores angiogenesis synergistically with VEGF upon LDL exposure despite CXCR4 internalization and degradation.
24008569 The VEGF -634CC and +936 TT genotypes were associated with a higher risk of glioma in a Han Chinese population.
24005038 The results have demonstrated that the major G-quadruplex formed in the VEGF promoter in K(+) solution is a parallel-stranded structure with a 1:4:1 loop-size arrangement.
23999841 The expression of HDGF significantly correlated with VEGF-A, but not Ki-67 expression.
23998120 P = 0.095) and healthy individuals (0.37 versus 0.19, OR = 2.51, P = 0.038). These results imply that VEGF and bFGF gene polymorphisms have prognostic significance in patients with NHL.
23992143 Both the VEGFR2 receptor and HIF-1alpha were expressed in alpha-SMA positive myofibroblast-rich nodules with characteristics of Dupuytren's disease in the active involutional phase.
23991063 Data indicate that induction of cyclin A1 overexpression in breast cancer cell line MCF-7 results in an enhanced invasiveness and a concomitant increase in vascular endothelial growth factor (VEGF) expression.
23985752 The expression of MIF mRNA was compared with VEGF mRNA expression and with mRNA expression of other chemokines related to neo-angiogenesis, such as CXCL12, CXCL11, CXCL8 and CXCR4, in human endometrial cancer tissue and normal endometrium.
23982876 A allele of VEGF -2578C/A polymorphism might be a risk factor for lung cancer, especially in smoker patients and SCC patients. However, the T allele of VEGF -460C/T polymorphism might be a protective factor for nonsmoker and SCC lung cancer patients.
23979202 CONCLUSIONS: We have identified the baseline VEGF/sVEGFR-2 and VEGF/TSP-1 ratios as potential biomarkers of response in ABCP treated metronomically with Cy+Cel. This finding warrants its confirmation in a higher number
23971975 Our study shows that VEGFA rs699947 and rs833061 and VEGFR2 rs2071559 polymorphisms do not modify the risk of suffering age related macular degeneration in a Spanish population.
23962084 The study suggests that the c.*237C>T and g.43737830A>G VEGF polymorphisms are useful markers of susceptibility to gallbladder cancer.
23957473 genetic polymorphism is associated with pre-eclampsia
23953866 VEGF which is representative of angiogenesis can be a new and useful predictor of preterm delivery.
23953100 These results suggest that the VEGF polymorphism influences the visual acuity prognosis in highly myopic eyes with CNV within 1 year after anti-VEGF treatment.
23952049 genetic association studies in population of women in Iran: Data suggest that an SNP in TNFalpha (tumor necrosis factor-alpha, -1031T/C) (but not an SNP in VEGFA, vascular endothelial growth factor A, +450G/C) is associated with endometriosis.
23950980 Aberrant DLL4 expression and HIF-1alpha/VEGF angiogenesis signaling may have a role in missed abortion.
23948549 VEGFA levels are higher in malignant pleural effusions compared with benign effusions.
23945248 role of VEGF polymorphism in lung cancer
23944367 This review examines the role of VEGF signaling in cancer and outlines the current status of anti-angiogenic therapies against VEGF pathway.
23943785 Stat signaling and VEGF expression are inhibited by the antiangiogenic plant flavone acacetin
23939376 At molecular level, the inhibitory effect of RERF on VEGF signaling is shown by the decreased amount of phospho-FAK and phospho-Akt
23937241 The VEGF expression and the microvascularization in salivary gland tumours are important elements to be considered when formulating a diagnosis and assessing case evolutions in patients with such tumours.
23935865 Data show that VEGF-A165b protein can be immunoprecipitated from cultured cells and that immunoprecipitating VEGF-A results in protein that is detected by VEGF-A165b antibody.
23933698 Data suggest that proliferating cells in pregnant and post-partum pituitaries do not release an increased amount of VEGF and other angiogenic factors, and thus do not cause angiogenesis or increase of microvessels in pituitary gland.
23932937 VEGF concentration was quantified in CM (ELISA) from agonist experiments; we observed a 2-fold and 2.5-fold increase in VEGF release from NPY and Y5R agonist treated 4T1 cells respectively
23929745 Lower serum BDNF and higher VEGF concentrations were associated with increased risk of incident stroke/TIA. Higher levels of BDNF were also associated with less white matter hyperintensity and better visual memory.
23927080 Vascular endothelial growth factor C-634G polymorphism (CC genotype) is a genetic risk factor for diabetic macular oedema, and its presence provides significantly better visual outcome following bevacizumab treatment.
23926105 Co-transfection of KLF-4 and HDAC1,2 expression plasmids in breast cancer cells results in synergistic repression of VEGF
23922493 An increase in serum VEGF and ICAM-1 levels is associated with an increase in the severity of diabetic retinopathy and the grade of external limiting membrane and inner segment-outer segment junction disruption.
23913375 Results show that VEGF +936C/T polymorphism is not associated with risk of overall cancer among Asians.
23912396 Hepatocellular carcinoma shows significantly elevated serum levels of angiogenic factors VEGF and Ang-2 and of anti-angiogenic factors endostatin and angiostatin.
23907576 VEGF expression was associated with poor overall survival in osteosarcoma, and there is no significant heterogeneity among all studies.
23907365 the suppression of VEGF expression subsequent to inhibition of MDM2 in p53 mutant cells suggests that MDM2 has a regulatory role on VEGF expression through a p53-independent mechanism.
23906304 Low VEGF expression is associated with endothelial damage and breast cancer.
23904001 VEGF 634G/C polymorphisms have a significant role in breast cancer susceptibility and aggressiveness.
23901275 Studied the effectiveness of an integrin peptide ligand-labeled liposomal delivery system loaded with vascular endothelial growth factor (VEGF)-siRNA in a model study of gene therapy for retinopathy using human retinal pigment epithelial cells.
23900443 DNA methylation-induced silencing of miR-126 contributes, at least in part, to tumor invasion and angiogenesis in colorectal cancer, through upregulation of VEGF expression.
23900206 VEGFA polymorphisms contribute to recurrent spontaneous miscarriage.
23899963 Angiogenic factors VEGF, HIF-1alpha and CD34 are important in breast cancer progression and their abundance in breast tumors has prognostic and predictive value.
23897578 VEGF/VEGF-R system contributes to enhance, but stunted myocardial angiogenesis in patients with tetralogy of Fallot
23894088 cyclic strain increased the expression of vascular endothelial growth factor (VEGF) and interleukin (IL)-6, which are critical to wound healing
23891064 Lower expression of ATF4 and VEGF genes in chorionic villus tissue may participate in the pathogenesis of spontaneous abortion.
23886210 High VEGF exprwession is associated with recurrence in breast cancer.
23886195 Increase of serum VEGF is associated with response to therapy in non- small cell lung cancer.
23884891 normal pancreatic VEGF-A expression is critical for the recruitment of ECs and the subsequent stimulation of endocrine cell proliferation during islet development. VEGF-A has a lesser role in adult islet function and beta-cell mass.
23884772 VEGF polymorphism is associated with susceptibility to intervertebral discs degeneration.
23884416 These findings establish NDST1 as a target of miR-24 and demonstrate how such NDST1 suppression in endothelial cells results in reduced responsiveness to VEGFA
23877020 Osteoprotegerin and VEGF are elevated in normoalbuminuric Type 1 diabetic subjects and are independently associated with glycemic indices and diabetes status.
23873676 PEI-PBLG/siVEGF complex provides a higher and more sustained suppressive effect by reducing VEGF mRNA expression in the tumors, leading to higher tumor growth inhibition efficacy
23870474 Estrogen increased the expression of VEGF, and thus activate ERK1/2 pathway to induce MMP-2/9 expression.
23868282 VEGF plasma levels in patients with amyotrophic lateral sclerosis (ALS) depend on changes in ventilation and exercise.
23867510 we review novel VEGF-directed agents that are being developed to address the shortcomings of current targeted drugs for the treatment of advanced renal cell carcinoma.
23863999 CXCR4-mediated osteosarcoma growth and pulmonary metastasis are promoted by Mesenchymal stem cells through VEGF.
23862573 high altitude
23861821 MicroRNA-196b regulates the HOXB7-VEGF axis in cervical cancer.
23860526 Among non-responders to metronomic cyclophosphamide for prostate cancer, the -2578CC genotype was more frequent, wherease the -634CC was more frequent in responders.
23851330 COX-2 and VEGF expression correlated with angiogenesis and tumor progression in classical Hodgkin lymphoma.
23848209 These findings suggest that the functional single nucleotide polymorphism (SNP) VEGFA rs699947 C/A allele may decrease the risk of rheumatoid arthritis in older patients and ACPA-negative patients.
23840094 Findings indicate skeletal muscle expression of antiangiogenic VEGF-A165b and preferential upregulation in IIM, suggesting that modulation of VEGF-A isoforms may occur in myositides.
23838428 Endogenous expression of human and rat VEGF-A165b was detected in hippocampal and cortical neurons.
23838139 VEGF overexpression is associated with a more advanced TMN stage and shorter OS in EC patients.
23831629 VEGF and VEGF receptors 1 and 2 have roles in malignant colonic epithelial cell growth through an autocrine mechanism
23831623 Lysophosphatidic acid-induced VEGF-A expression is regulated by hypoxia-inducible factors (HIF)-1alpha and HIF-1beta in prostate cancer (PC)-3 cells.
23828162 High VEGF level was associated with inflammation.
23827227 Serum VEGF levels in Alzheimer disease patients were significantly lower than in patients with mild cognitive impairment, which were in turn lower than in controls.
23807724 These data demonstrate that Bmi-1 plays a vital role in HCC invasion and that Bmi-1 is a potential therapeutic target for HCC
23807031 These findings suggest that PGIS is induced by hypoxia and regulates the expression of VEGF in fibroblasts
23794399 Single nucleotide polymorphisms in VEGFA gene is associated with colorectal cancer risk.
23794239 VEGF did not accelerate or enhance differentiation of human MSCs towards endothelial cells but was vital for specification of arterial fate.
23790363 Data suggest that placental oxygen supply is capable of altering metabolism; varying oxygen tension appears to regulate gene expression of VEGFA and ABCG2 (breast cancer resistance protein) in first trimester placental villous explants.
23780896 Data indicate that expressions of PTHrP, EPO, and VEGF were respectively related to advanced stage of clear cell renal cell carcinoma (ccRCC).
23773968 High serum levels of TIMP-1 and VEGF-A were found to be associated with tumor progression and unfavorable prognosis in patients with esophageal cancer.
23772669 VEGF-A, VEGFR-1 and VEGFR-2 were statistically correlated with ramifications of blood vessels. No correlation with patient outcome was observed.
23772632 There was a statistically significant inverse association of CD34 expression with adverse histological features, and a positive correlation of VEGF and cytoplasmic beta-catenin staining with unfavourable microscopic parameters in breast phyllodes tumors.
23771673 Upregulation and maintenance of HIF-1alpha and NGF expression may attenuate VCI.
23767832 No difference was observed in terms of VEGF, PIGF and HIF-1alpha in a comparison of the early- and late-onset pre-eclampsia groups.
23765166 results demonstrated that VEGF enhanced the expression of MRP1, and the PI3K/Akt signaling pathway and SP1 may be involved in this modulation
23761723 The results suggest the VEGF-A rs1413711 and rs833061 polymorphisms may contribute to age-related macular degeneration susceptibility.
23760290 Inflammation mediators act through c-Fos to increase VEGF production in peritoneal mesothelium.
23759331 Silencing GRP78 not only inhibits tumor, but also decreases the expression of VEGF and VEGFR2 in colon cancer.
23756256 Forty-nine Grade I, 33 Grade II, and 6 Grade III meningiomas were observed. VEGF and Ki-67 expression was correlated with higher tumor grade. A correlation was observed between COX-2 expression and invasiveness to the brain or adjacent soft tissue.
23756092 Patients with survivin or VEGF mRNA positivity postoperation had markedly shorter disease-free survival.
23755151 Elevated plasma levels of Ang-1 and VEGF were found in patients with malaria resulting from in vivo platelet activation.
23754270 Oxymatrine decreased the expression of angiogenesis-associated factors, including nuclear factor kappaB (NF-kappaB) and vascular endothelial growth factor (VEGF).
23749886 VEGF and VEGFR1 mRNA levels were significantly higher in bladder cancer specimens than that of normal mucosa; results suggest that alterations in the expression of VEGF and VEGF receptors are associated with disease stage and recurrence
23749764 Ovarian endometrioma decreases VEGF levels in the surrounding ovarian tissues.
23748230 VEGF expression proved to be an independent negative predictor for LRC, MFS and OS in patients treated for locally advanced SCCHN with adjuvant radiotherapy or radiochemotherapy. FLT-1 expression was not significant in multivariate analyses.
23745581 A potential pharmacogenetic relationship between the VEGFA gene and treatment response to anti-VEGF therapy, is demonstrated.
23737650 Increased expression of VEGF and CD31 in postradiation rectal tissue: implications for radiation proctitis.
23737289 VEGF overexpression indicates a poor prognosis for patients with oral carcinoma of the salivary glands. [Meta-analysis]
23728502 different VEGF genotypes did not seem to significantly modify the main clinical features of the disease
23728336 Data indicate the role of osteopontin (OPN) under hypoxia and in breast tumor growth and angiogenesis through NF-kappaB-mediated HIF1alpha-dependent vascular endothelial growth factor (VEGF) expression.
23727146 acute hypoxic exposure for up to 60 min does not induce a generalized inflammatory response, but does induce the expression of HIF-1a and VEGF
23725155 High vascular endothelial growth factor in bronchoalveolar lavage fluid is associated with primary lung cancer.
23725153 Vascular endothelial growth factor gene polymorphisms are associated with breast cancer risk.
23722461 Thalidomide significantly attenuated TGF-beta1-induced VEGF expression in human lung fibroblasts.
23719599 The polymorphism, +405G/C but not -460T/C and +936C/T, of VEGF gene is strongly associated with pancreatic adenocarcinoma, and this SNP has significant influence on serum VEGF level.
23714383 Autocrine IL-8 and VEGF synergistically activate ATF-2 mediated invasiveness in A549 lung cancer cells.
23713888 In contrast to current belief, platelet pro-angiogenic responses are independent of VEGF and appear to be the result of the combined action of several molecules.
23711571 Our data suggest a role of VEGF in the pathogenesis of Ppsoriatic arthritis.
23711375 VEGF-A-induced soluble VEGFR-1 upregulation can operate as a negative feedback system.
23701307 Plasma VEGF was significantly reduced in low birth weight (LBW) neonates while that of sVEGFR-1 and PF4 were significantly higher. VEGF/sVEGF/PF4 pathway seems to be involved in the endothelial progenitor cell dysfunction in LBW neonates.
23699597 These data identify a critical role for Wt1 in hematopoiesis and Vegf-a as a cellular RNA whose splicing is potentially regulated by Wt1.
23698113 Insulin regulates VEGF-A in the podocyte
23695013 Natural fungal bioactive compound chaetoglobosin K effectively inhibits angiogenesis through downregulation of vascular epithelial growth factor (VEGF)-binding hypoxia inducible factor (HIF)-1alpha.
23690937 TLR-4 and VEGF polymorphisms in chronic periaortitis
23688054 The level of VEGF showed significant correlations with lymph node metastasis and distant metastasis in in malignant pleural effusions of lung cancer patients.
23687977 Data show that the expressions of ER-alpha, PR, LIF, VEGF, iNOS and CB1 in fallopian tube and chorionic villi of tubal pregnancy were not altered by exposure to levonorgestrel emergency contraception.
23682725 VEGF induces oscillations in [Ca(2+)]i that are patterned by the interaction between inositol-1,4,5-trisphosphate-dependent Ca(2+) release and store-operated Ca(2+) entry.
23679318 High plasma level of VEGF-A is associated with prostate cancer.
23679262 High VEGFA expression is associated with breast cancer.
23674658 Studied the usefulness of (18)F-fluorodeoxyglucose FDG-PET/CT and the relationships among the expressions of HIF-1alpha, Glut-1 and VEGF, histological type, other clinical factors and FDG uptake in thymic epithelial tumours.
23673188 study showed higher levels of both VEGFA mRNA in the peripheral blood cells and serum VEGF in patients diagnosed with rDD than in healthy controls.
23667446 A pattern of high VEGFA expression with low expression of secreted semaphorins was associated with 60% of triple-negative breast tumors.
23665907 VEGF markedly induces CXCL1 release in A549 lung epithelial cells.
23661335 IL-17A, IL-17B, IL-17F and IL-23 in systemic lupus erythematosus patients were examined and the correlation between levels of the investigated cytokines and VEGF, PIGF, as well as number of endothelial cells, was investigated.
23656623 The stimulatory effect of roflumilast on VEGF release was replicated using primary healthy and COPD lung fibroblasts.
23654314 Serum level of VEGF increases in pre-eclampsia
23652833 In human ovarian epithelial carcinoma cells (HO-8910), resistin (10-150 ng/mL) enhanced both VEGF protein and mRNA expression in a time- and concentration-dependent manner, as well as promoter activity.
23651239 Data show expression of TGF-beta1, TGF-beta2, BMP-4, and BMP-7 was increased in tumor-associated macrophages (TAMs) cocultured with pancreatic cancer cells, and vasohibin-1, VEGF-A, and vVEGF-C expression in pancreatic cancer cells was upregulated by TAMs.
23650550 VEGF overexpression significantly alters extracellular matrix integrity in MCF-7 tumors, causing them to progress to an invasive and metastatic phenotype.
23649946 REVIEW: Soluble mediators of diabetic macular edema: the diagnostic role of aqueous VEGF and cytokine levels in diabetic macular edema
23648010 Increased CD16(+ ) NK cells were associated with IL-6 and VEGF deficiency in a high proportion of UI-IF(unexplained infertility with implantation failure) patients.
23645351 we explored heterogeneity in expression of EGFR, VEGF and NOTCH1 in head and neck squamous cell carcinomas
23644986 there is no association between the carrier states of gene polymorphisms VEGF +405, VEGF +936 and progression or spontaneous regression of ROP in preterm infants in Iranian population.
23639731 high VEGF levels have a potential application in predicting non-responder patients with CSF drainage for ventriculomegaly
23636606 NET-1 and VEGF silencing play a key role in inhibiting hepatocellular cell proliferation, promoting apoptosis, and reducing angiogenesis.
23625573 Polymorphism in VEGF gene is associated with breast cancer.
23624620 Primary cutaneous large B-cell lymphomas were characterized by significantly higher intratumoral expression levels of VEGF and its receptors in comparison with the indolent lymphoma subtypes.
23620752 The mRNA expressions of the proangiogenic growth factors VEGF, PDGF, bFGF and their receptors (VEGFR1, VEGFR2, PDGFRA, PDGFRB, FGFR1, FGFR2) were measured and compared in gastric ulcers of cirrhotic patients.
23618468 This study revealed no statistically significant prognostic or predictive value of VEGF expression for locally advanced prostate cancer
23613412 Serum VEGF levels may be used for assessing of the efficacy of anti-angiogenic therapies.
23613251 overexpression of survivin and VEGF accompany a higher risk of BTCC recurrence, making survivin and VEGF biomarkers for predicting the relapse of bladder cancer.
23613250 the rs3025039 (C>T) polymorphism of the VEGF gene increases the risk of endometriosis, but the rs699947 (A>C) and rs1570360 (G>A) polymorphisms might be protective factors for endometriosis.
23608225 The VEGF and COX-2 mRNAs were identified as the bona fide targets of miR-101 in cholangiocarcinoma cells.
23605255 indicative of good tumor blood supply and permeability of vasculature, are associated with high levels of collagen XVIII and VEGF expression
23604117 HIV-1 Tat upregulates VEGFA (VEGF) expression in HUVEC and EA.hy926 cells
23602531 Letter: serum VEGF was not elevated in chronic spontaneous urticaria.
23599627 galectin-1 has a role in regulating VEGF expression in gastric cancer
23592143 This study showed that overexpression of NOSTRIN had a significant effect on eNOS activity in HUVECs and resulted in significant cellular damage.
23592000 A polymorphism in VEGF and its protein level were associated with chronic periodontitis in a Chinese population
23591828 Heart-type fatty acid binding protein (hFABP) and VEGF CSF concentrations distinguished between healthy controls and patients with AD dementia with a sensitivity and specificity of 57 and 35%, and 76 and 84%, respectively
23589053 High VEGF expression is associated with osteosarcoma.
23588859 C-myc-dependent downregulation of VEGF induced by all-trans-retinoic acid contributes to the differentiation of HL-60 cells.
23586368 Our results suggest that the VEGF gene polymorphism (936 C>T) contributes increased susceptibility to oral cancer.
23572336 Increased plasma levels of the VEGF165b splice variant are associated with the severity of nailfold capillary loss in systemic sclerosis.
23569009 The present study findings suggested that the VEGF +936 TT genotype was associated with age-related macular degeneration among Han Chinese patients.
23564055 Preoperative serum levels of CA125 and VEGF were significantly higher in patients with epithelial ovarian cancers compared to those with ovarian cysts. The addition of VEGF to CA125 increased the sensitivity of early ovarian cancer detection.
23559636 Report lack of vascular growth responses after VEGF treatment in ischemic stroke under conditions of hyperlipidemia.
23555666 Mineralocorticoid receptor activation attenuates the expression of the VEGF receptor 2/KDR, possibly dampening the activation of a VEGFA/KDR dependent signaling pathway important for the survival of tumor cells under hypoxic conditions.
23554900 MCF7 and MDA-MB-231 cells treated with leptin secreted more VEGF than untreated cells, whereas adiponectin treatment inhibited VEGF secretion.
23553563 Mountain sickness was found significantly associated with VEGFA SNPs compared with Chinese control groups, indicating that base substitutions result in transcription factor binding site changes which have an effect on development of altitude sickness.
23552871 High levels of circulating VEGF predicts poor overall survival in lung cancer, yet it does not predict poor progression free survival. [Meta-analysis]
23552178 The serum levels of IL-33/sST2 were remarkably higher in the patients with ankylosing spondylitis than the healthy groups and significantly correlated with vascular endothelial growth factor and the Bath Ankylosing Spondylitis Disease Activity Index.
23551429 None of the five VEGF and VEGFR-2 gene polymorphisms investigated in this study was found to be an independent prognostic marker for Korean patients with surgically resected GIST.
23548900 Endomembrane H-Ras controls vascular endothelial growth factor-induced nitric-oxide synthase-mediated endothelial cell migration.
23545315 CAD patients had significantly higher frequency of the VEGF rs699947 A allele.
23542734 Patients with influenza A/H1N1 infection and acute respiratory distress syndrome/acute kidney injury have an over-production of MCP-1, VEGF and IP-10 possibly contributing to kidney injury and are associated to a higher risk of death.
23522390 the increased levels of angiogenic factors VEGF in hydatidiform moles may link to the mechanism of developing very early onset preeclampsia
23520314 CFTR dysfunction triggers epithelial synthesis of VEGF-A, which may contribute to vascular remodelling
23511629 patients with TT polymorphism of rs833061, CC polymorphism of rs699947, CC polymorphism of rs2010963 and CG polymorphism of rs6877011 seem to have a worse PFS and OS when receiving first-line sunitinib.
23499421 This is the first study demonstrating an association between the VEGF +936 CC genotype and the risk to develop AKI in patients with severe sepsis.
23485997 Rac1, HIF-1alpha, and VEGF play an important role in tumor invasion and metastasis, especially in tumor angiogenesis.
23481572 Results suggest that lower doses of chemotherapeutic drugs decrease VEGF secretion from tumor cells without causing substantial cell killing.
23475388 analysis of expression of VEGF and its receptors VEGFR1 and VEGFR2 in primary and recurrent WHO grade III meningiomas
23470436 In contrast to the VEGF association of the previously-described aV DNA aptamer, where the binding is enthalpically driven and sequence-specific, the binding of the aHt aptamer to VEGF is entropically-driven and not abolished by scrambling of the sequence.
23467576 The simultaneous RNA interferencemediated downregulation of survivin and VEGF expression inhibited proliferation and induced the apoptosis of Panc1 cells and human umbilical vein endothelial cells.
23465821 Chorionic gonadotropin induces VEGFA-dependent downregulation of VE-cadherin, nectin 2, and claudin 5, which increase endothelial permeability in the coculture system.
23464465 PTEN, VEGF, HER2, p53 expressions were compared with bevacizumab response.
23464458 The prevalence of VEGF expression was 63.5%.
23463593 High VEGF expression is associated with low response to chemotherapy in non-small cell lung cancer.
23462604 Serum levels of VEGF, HIF-1alpha and IGF-I were significantly higher in the diabetic patients than in the controls.
23459872 Our data indicate that VEGF expression is efficiently inhibited in A549 cells by ASODN transfection and this inhibition leads to inhibited cell growth and impaired cell cycle distribution.
23454747 Tumor cells proliferation reduces in a VEGF/VEGFR2-dependent manner as long as the nutrient supply remains decreased.
23454149 6,6'-bis(2,3-dimethoxybenzoyl)-alpha,alpha-trehalos could inhibit invasion and angiogenesis by downregulation of VEGF and MMP-9 in MDA-MB-231 breast cancer cells.
23449351 High VEGF expression is associated with metastatic colorectal cancer.
23448535 Together, VEGF and NOS3 play an important role in the pathogenesis of the microvascular complications of diabetes. [review]
23444216 Studies indicate that as a decoy VEGF receptor, aflibercept (VEGF-Trap) has binding affinity for VEGF-A, VEGF-B and placenta growth factor PGF.
23435217 Data indicate that dual inhibition of EGFR with erlotinib and cetuximab, combined with the VEGF antibody bevacizumab, is well-tolerated, and merits further investigation.
23430447 Single nucleotide polymorphisms in the promoter region of VEGF gene are associated with bladder cancer risk.
23429999 Angiogenic responses to VEGF are compromised in hypercholesterolemia as a consequence of endosomal VEGFR2 degradation.
23429328 The correlation between T stage of gastric cancer and the higher expression of CD40, VEGF, AKT, and PI3K, along with lower S100 expression in DC, may provide insights into future targets for more effective immunotherapy for cancer.
23428182 In brain microvascular endothelial cells, VEGF is upregulated by advanced glycation end-products induction of basement membrane hypertrophy.
23421942 study demonstrates that correlation analysis of E2/VEGF-A and E2/PIGF serum levels may be able to distinguish a tubal ectopic pregnancy from a normal pregnancy
23421785 Serum concentrations of VEGF are increased in patients with unstable angina pectoris.
23413901 Studies indicate that VEGF is a potent angiogenic vasoactive molecule, and TNF-alpha augments angiogenesis through the expression of VEGF and its endothelial receptor (VEGF receptor 2).
23405237 Elevated circulating VEGF levels are associated with type 2 diabetes microvascular complications.
23404377 this study indicates that ROS and aberrant expression of Nrf2 play an important role in FSH-induced angiogenesis in OEC, and provides insight into the mechanisms of FSH-induced VEGF expression.
23403511 Data indicate that pretreatment with the MEK/ERK inhibitor U0126 prevented the rapamycin-induced increases in pCREB, Bcl-2, and VEGF-A expression.
23401860 VEGF and PKC promote degradation-independent protein ubiquitination of FLNB to control intracellular trafficking of HDAC7.
23401418 Serum VEGF was significantly higher in infants living at high altitude compared to low altitude residents.
23398358 The VEGF-A pathway and tumor capillary length may be essential for peritumoral brain edema (PTBE)-formation in meningiomas.
23392717 The influence of early-stage intensive insulin therapy on the plasma levels of vascular endothelial growth factor (VEGF) and the related parameters in patients with severe trauma and the clinical implication were investigated.
23390884 VEGF -2549 I/D polymorphism has a role in the susceptibility to breast cancer in the Amritsar region of Punjab, India
23384557 Elevated expression of LSD1, but not JMJD2A, correlates with prostate cancer recurrence and with increased VEGF-A expression.
23383089 a novel regulatory mechanism for VEGFA transcription by OASIS in human retinal pigment epithelial cells
23374253 Endorepellin binds through its proximal LG1/2 domains to VEGFR2 and inhibit VEGFA-dependent endothelial migration.
23374220 Data suggest that G/G genotype of VEGF -634 G/C polymorphism is related to the higher serum levels of VEGF, and poor clinical outcome in FOLFOX-treated advanced gastric cancer patients.
23370341 Conclusively, the result of this meta-analysis suggested that VEGF promoter polymorphisms (-2578C/A, -1154G/A) might not contribute to the susceptibility of Alzheimer's disease
23369005 Induction of VEGF expression in prostate cancer cells is mediated through the core promoter region and is dependent upon a critical Sp1 binding site.
23367565 VEGF expression is induced in human monocytes by Dengue Virus infection.
23364276 Plasma VEGF levels are elevated in women with metabolic syndrome.
23359195 Vascular endothelial growth factor concentrations in breast cancer patients do not correlate with recognized clinicopathological prognostic factors
23358800 It involved in the same cascade of the malignant progression of gliomas.
23353010 research confirmed the association between the VEGF -634G>C polymorphism and diabetic retinopathy in subjects with type 2 diabetes
23352645 a novel mechanism for hypoxia-induced FGF2 and VEGFA through HIF1alpha-mediated inhibition of miR-503
23350796 No robust association is found between plasma VEGF levels and cerebral deep white matter integrity in any area, adjusted for age and gender.
23350655 The increase in placental expression of the VEGF-A gene and the resultant stimulation of angiogenesis are a response to hypoxic environment developing in the placental tissue in intrauterine growth restriction.
23350126 Expression of VEGF-A genes in glioma cell lines U87 is significantly changed under hypoxia and ischemic conditions.
23346798 In patients with wet age related macular degeneration, a strong positive correlation between VEGF and PEDF concentrations was observed and significantly higher PEDF and VEGF plasma levels in patients with bilateral manifestations of the disease.
23340303 VEGFA amplification is associated with response to therapy in metastatic breast cancer.
23339636 Low VEGF and high sVEGFR-1 concentrations seem to be associated with the severity of Respiratory distress syndrome irrespective of preeclampsia, suggesting that VEGF may be one of the main components of lung maturation.
23335846 A model in which the sustained synthesis of VEGF in lens epithelial cells, maintained under hypoxic condition, is regulated by a compensatory inter-relationship between HIF-1alpha and HIF-2alpha
23335070 These results suggest the possible association of the VEGF polymorphism with high risk B cell chronic lymphocytic leukemia
23334331 Under hypoxic conditions, upregulation of EMP2 promoted vascular endothelial growth factors (VEGF) expression through a HIF-1alpha-dependent pathway and resulted in successful capillary-like tube formation
23332617 Increased VEGF-A levels were detected in patients with Fabry disease compared to the controls.
23332132 EpCAM, FR-alpha, and VEGF-A are the most promising molecules for use in targeted intraoperative fluorescence imaging of endometriotic lesions owing to their favorable expression patterns and biomarker characteristics
23329570 Increased expression of VEGF and its receptors might be crucial in the proliferation of thyrocytes and therefore may contribute to the development of goiter and goiter recurrence.
23328414 Patients with diabetes type 2 with no-retinopathy and with non-proliferative retinopathy had high levels of inflammatory and angiogenic markers like VEGF, which decreased in patients with diabetic proliferative retinopathy.
23326500 This study is the first to demonstrate that Activin-A/BMP-4/VEGF protocol efficiently differentiates cardiomyocytes from human umbilical cord blood mononuclear cell derived hiPS
23326384 Data indicate an increase of VEGF, HIF-1alpha expression and microvessel density (MVD) in BRCA1-2 carriers and BRCAX compared to the sporadic control group.
23321170 Two SNPs, rs3025039 (which involves a C-->T allele variation at position 936 in the 3' untranslated region) and rs3025030 (which involves a G-->C allele variation in the intronic sequence), were associated with a decreased risk of acute mountain sickness.
23321169 Phosphorylated Akt and VEGF-A are involved in angiogenesis of gastric adenocarcinoma, and Akt activation may contribute to angiogenesis via VEGF-A upregulation.
23317892 Investigated the mechanism of expression and significance of vascular endothelial growth factor (VEGF) and p53 in degenerate intervertebral disc tissue.
23315815 The 1154 G/A polymorphism A/A genotype of the VEGF gene was found to be more frequent in women with recurrent pregnancy loss.
23313225 Serum VEGF concentrations are elevated and can serve as a surrogate marker of myocardial injury.
23303013 In 10 cases with RA and five OA, immunohistochemical stains were performed with CD31 and VEGF-A (Vascular Endothelial Growth Factor).
23303012 Human adipose depots show a different incidence of VEGF positive cells in relation with their disposal and the metabolic status.
23302311 VEGF was strongly expressed in adrenocortical carcinomas but only moderately expressed in adrenocortical adenomas.
23301033 HIV-1 Tat upregulates VEGFA (VEGF) expression in HUVEC and EA.hy926 cells
23295255 A high level of serum VEGF is an independent prognostic factor in patients with advanced gastric cancer treated with chemotherapy
23293323 Studies suggest that vascular endothelial growth factor may be responsible for upregulated P-glycoprotein expression.
23293030 DEAD-box RNA helicase 6 (DDX6) is a cellular modulator of vascular endothelial growth factor expression under hypoxia
23290762 Expression levels of VEGF and bFGF are significantly decreased in pressure ulcer wounds at stage III-IV.
23288726 Our study showed that the TT genotype of Vascular endothelial growth factor was associated with increased lung cancer risk than those with the CC genotype
23285958 VEGF induced angiogenesis in nasopharyngeal carcinoma tissue, and plays an important role in disease progression. There was positive correlation between VEGF and microvessel density in nasopharyngeal carcinoma tissue.
23280079 Thrombin mediates an excess in the production of neoangiogenetic (VEGF) and profibrotic (PAI-1) factors in human peritoneal mesothelial cells.
23279742 Largazole ameliorates liver fibrosis by disrupting angiogenic VEGF signalling.
23272609 Authors present the role of vascular-endothelial growth factor in the process of angiogenesis and the biology of the lung cancer and antiangiogenic therapy directions.[review]
23272057 CDF, a curcumin derivative, increases expression of VEGF, IL-6 and miR-21 and hypoxia-induced aggressiveness of pancreatic cancer cells
23269798 VEGF derived from tumor cells acts to increase Vaccinia virus internalization, resulting in increased replication and cytotoxicity in an AKT-dependent manner in both tumor cells and normal respiratory epithelial cells.
23269488 High expression of vascular endothelial growth factor is associated with squamous cell carcinoma of head and neck.
23265127 VGEFA expression my play a role in tumorigenesis in patient diagnosed with colorectal cancer.
23264219 The increased CD105/CD31 and VEGF/CD31 ratios in gingiva confirms an augmented proliferative fraction of the endothelium in gingiva with chronic periodontitis.
23264084 Positive association of the vascular endothelial growth factor-A +405 GG genotype and poor survival in stage I-II gastric cancer in the Northern Chinese population.
23257745 the results obtained in the study confirm the role of the VEGF gene in the pathogenesis of amyotrophic lateral sclerosis in a Russian population.
23254958 Treatment of breast cancer cells with PPAR-gamma agonists elevated the expression of leptin and VEGF mRNA and protein, and increased cell viability and migration.
23254951 Downregulation of VEGF-A and VEGFR-2 expression mediated by Jiedu Xiaozheng Yin, a Chinese herbal formula, inhibits tumor angiogenesis.
23254909 these results indicated that stimulation of ovarian cancer cell VEGF, Cox2 and survivin expression by FSH involves the microRNA27a: ZBTB10-specificity protein pathway
23250775 VEGF, VEGF-R1 and VEGF-R2 are over-expressed in tumour epithelial cells in oesophagogastric cancer.
23243026 Endocan is upregulated on tumor vessels in invasive bladder cancer where it mediates VEGF-A-induced angiogenesis.
23239744 Upregulation of Dll4 expression in acute myeloid leukemia cells suppressed VEGF-induced endothelial cell proliferation.
23236888 Delivery of the therapeutic genes VEGF and FGF2 to the damaged region and their expression in cell carriers stimulates vascularization and post-traumatic spinal cord regeneration.
23236677 Serum levels for Vascular Endothelial Growth Factor 1 above 158.5 pg/ml; Inhibin A above 98.50 ng/ml; PIGF levels above 30.01 pg/ml shows a diagnostic sensitivity 88.895 and diagnostic specificity 97.06% in prediction of preeclampsia.
23232696 Data indicate that the median levels of Ang-1, Ang-2 and VEGF mRNA were significantly higher in patients harboring BRCA1/2 germline mutations.
23227881 Possible reciprocal interactions between smoking and VEGF-SNP function were observed. Multivariate analysis confirmed VEGF +405 G/G genotype to be associated with poor survival in advanced OSCC; further use of this haplotype as biomarker needs discussion.
23225320 Histamine was able to synergistically augment bFGF-induced angiogenesis, and this action was linked to VEGF production through H1-receptor.
23224211 Differences in intravitreal cytokine levels in DRP, RVO and ARMD could be demonstrated.
23222716 Data indicate that Overexpression or knockdown of miR-145 altered both the mRNA and protein levels of HIF-2alpha and its downstream genes, cyclin D1, matrix metalloproteinase 14 and vascular endothelial growth factor, in neuroblastoma cells.
23221067 VEGF and VEGFR-2 was detected in macrophages and endothelia of abnormal vessels in eyes with Coats' disease.
23220088 delta-catenin overexpression in prostate cancer CWR22Rv-1 cells results in increased HIF-1alpha and VEGF expression
23217559 HDAC1, LL-37 and VHL can modulate the production of VEGF via HIF-1alpha in HaCaT cells
23213275 Genetic variations at VEGF-460C and IFN-gamma +874T might accelerate the pathogenesis of retinal neovascularization in proliferative diabetic retinopathy.
23212515 ZNF24 represses VEGF transcription through direct binding to an 11-bp fragment of the VEGF proximal promoter and that it functions as a negative regulator of tumor growth by inhibiting angiogenesis.
23211130 VEGF gene has a role in polymorphisms in recurrent spontaneous miscarriage
23206462 Elevated VEGF induced by Hantaan virus infection may play an important role in the vascular hyperpermeability.
23204297 contribution of VEGFA variants to the variation of blood lipid levels
23201159 MiR-145 suppressed AKT and ERK1/2 pathways and HIF-1 and VEGF expression by targeting N-RAS and IRS1
23192572 Local administration of VEGF and rhBMP-2 augments angiogenesis, osteoblastic activity and bone blood flow from implanted blood vessels of donor origin in vascularized bone allografts
23182805 Our data suggest that VEGF level is associated with progressive loss of cognitive function in patients with Alzheimer's disease.
23181555 Report up-regulation of VEGF expression in sarcoid granulomas.
23177780 The increased expression of VEGF in adenoid tissues suggests a possible role of the IL-6/VEGF axis in the pathogenesis of hypertrophied adenoids in children.
23176363 Results of this study provide evidence of VEGF involvement in endometrial carcinogenesis and indicate potential use as a molecular indicator of disease progression.
23172303 Data suggest that signaling via VEGFA-VEGFR1/FLT1 and VEGFA-VEGFR2/FLK1 plays central roles in regulation of angiogenesis and lymphangiogenesis; VEGFA-VEGFR/FLT1 and VEGFA-VEGFR2/FLK1 signaling is crucial for tumour angiogenesis. [REVIEW]
23169435 In this comprehensive evaluation, pretreatment total circulating VEGF-A was prognostic for outcome in metastatic colorectal, lung, and renal cell cancers, but it was not predictive for bevacizumab-based treatment benefit.
23169005 VEGF polymorphism is associated with colorectal cancer.
23168996 VEGF was reduced in the CSF of suicide attempters. CSF VEGF showed a significant negative correlation with depression severity.
23167810 endometriosis is not associated with gene mutations for VEGF at codon 1154 G/A
23166713 The expression levels of microRNA-361-5p and its target VEGFA are inversely correlated in human cutaneous squamous cell carcinoma.
23161411 study demonstrated a significant relation between a lower incidence of grade 2 or higher bevacizumab-related hypertension and the VEGF-2578 C/C genotype for the entire treatment period in Japanese patients with metastatic colorectal cancer
23160675 vascular endothelial growth factor (VEGF), a promoter of angiogenesis, which is not significantly altered through compensation, and therefore would not need additional regulation for suppressive bcl-2 therapy to be effective
23155356 VEGF -634C/G is possibly predictive of long-term survival after treatment with a definitive 5-FU/CDDP-based CRT.
23155236 Lung cancer Adenocarcinoma and squamous cell carcinoma cell lines exhibit different VEGF-A responses to hypoxia
23155231 Protein kinase C is critically responsible for rapid VEGF secretion by gastrin-releasing peptide receptor signaling in neuroblastoma cells
23151382 By augmenting VEGFR2 expression in the placental amnion, PBEF primes the tissue for a VEGF-mediated increase in permeability.
23145112 Utilizing the information on Nrp ligand binding specificity, we demonstrate Nrp constructs that specifically sequester Sema3 in the presence of VEGF-A
23144758 Data indicate that inhibition of Nox4 expression inhibited the transcriptional activity of VEGF through HIF-1.
23137522 data show that higher levels of VEGF-A(CSF) are closely related to CNS leukemia (CNSL), and VEGF-A(CSF) may be a better predictor than the other risk factors elucidating the pathogenesis and development of CNSL
23132736 our results suggest that the VEGF -2578C>A variant may be a potential genetic marker for rectal cancer prognosis. Further large population studies are warranted to define whether the -2578C>A polymorphism is a prognostic marker of rectal cancer.
23129289 VEGF is an endothelial cell survival factor required for effective coupling of angiogenesis & osteogenesis. It has a role in postnatal bone repair. Review.
23128854 somatostatin limits VEGF release through its interaction with miR-361, indicating that miR-361 participates in the adaptive response of human umbilical vein endothelial cells to hypoxia
23118492 Findings suggest that HMGB1, VEGF, sVE-cadherin and sEng regulate the angiogenesis in proliferative diabetic retinopathy.
23117246 High VEGF expression is associated with progression of gastric carcinoma.
23114032 Exposure of SHED to EGM2-MV supplemented with VEGF induced activation of ERK/Akt signaling; inhibited phosphorylation of STAT3. analysis unveiled VEGF/MEK1/ERK signaling pathway as key regulator of endothelial differentiation of pulp stem cells.
23108136 We identified a novel mechanism of tumor escape by which VEGF-A directly triggers Treg proliferation.
23104894 VEGF-A splice isoforms may interfere with bevacizumab treatment of colorectal carcinoma.
23104639 The VEGF +405 G/C polymorphism may influence embryo implantation and VEGF + 405 C/C genotype may predispose to recurrent implantation failure after ICSI-ET.
23102786 VEGF inhibits starvation regulated endothelial lipase expression via SREBP-2.
23098453 High VEGF expression is associated with vulvar squamous cell carcinoma.
23098361 A higher serum VEGF level was found in tuberculous meningitis patients compared to controls.
23096096 Immunoreactivity for VEGF was enhanced in scleroderma patients, in contrast to restricted positive immunostaining in suprabasal keratinocytes observed in normal skin.
23094709 there is no association between the carrier states of gene promoter polymorphisms VEGF (-634) C, VEGF (-460) C, and VEGFR-2, and progression or spontaneous regression of ROP in preterm infants.
23093658 Data suggest that VEGFA is required for health of glomerular epithelial cells (i.e., to avoid apoptosis) and that this requirement is more critical in setting of hyperglycemia (i.e., to avoid diabetic nephropathy) than in euglycemia.
23089226 VEGF stimulates endothelial cell migration through increased S-glutathiolation of SERCA and calcium influx in a Nox4- and hydrogen peroxide-dependent manner, requiring Nox2 downstream.
23086933 beta-Catenin and peroxisome proliferator-activated receptor-delta coordinate dynamic chromatin loops for the transcription of vascular endothelial growth factor A gene in colon cancer cells
23086340 This work reveals an anti-angiogenic role of STAT1 activation that acts in Tie2-R849W-expressing endothelial cells to impair VEGF-A-mediated STAT3 signaling, bFGF production, and smooth muscle cell recruitment.
23086295 Combined whole-body vibration, resistance exercise, and sustained vascular occlusion increased skeletal muscle VEGF transcripts.