Tbio VAX1 Ventral anterior homeobox 1

Protein Summary

Description

Transcription factor that may function in dorsoventral specification of the forebrain. Required for axon guidance and major tract formation in the developing forebrain. May contribute to the differentiation of the neuroretina, pigmented epithelium and optic stalk (By similarity). This gene encodes a homeo-domain containing protein from a class of homeobox transcription factors which are conserved in vertebrates. Genes of this family are involved in the regulation of body development and morphogenesis. The most conserved genes, called HOX genes are found in special gene clusters. This gene belongs to the VAX subfamily and lies in the vicinity of the EMX homeobox gene family. Another member of VAX family is located on chromosome 2. The encoded protein may play an important role in the development of anterior ventral forebrain and visual system. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q5SQQ9
• B1AVW5
• Q6ZSX0

Gene Name

• VAX1

Ensembl ID

• ENST00000277905
• ENSP00000277905
• ENSG00000148704
• ENST00000369206
• ENSP00000358207

Symbol

• MCOPS11

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
microRNA	0.84
biological process	0.76
cell type or tissue	0.65
PubMedID	0.59
protein domain	0.58

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Helix-turn-helix Transcription Factor / Homeodomain Transcription Factor / Ventral Anterior Homeobox 1

Protein / Nucleic Acid Binding / Dna Binding Protein / Ventral Anterior Homeobox 1

DTO Classes

Protein / Transcription Factor / Helix-turn-helix Transcription Factor / Homeodomain Transcription Factor / Ventral Anterior Homeobox 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.62   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 130   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.62   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 130   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0