| Tbio | Synaptic vesicle membrane protein VAT-1 homolog |
Possesses ATPase activity (By similarity). Plays a part in calcium-regulated keratinocyte activation in epidermal repair mechanisms. Has no effect on cell proliferation. Negatively regulates mitochondrial fusion in cooperation with mitofusin proteins (MFN1-2).
Synaptic vesicles are responsible for regulating the storage and release of neurotransmitters in the nerve terminal. The protein encoded by this gene is an abundant integral membrane protein of cholinergic synaptic vesicles and is thought to be involved in vesicular transport. It belongs to the quinone oxidoreductase subfamily of zinc-containing alcohol dehydrogenase proteins. [provided by RefSeq, Jul 2008]
Synaptic vesicles are responsible for regulating the storage and release of neurotransmitters in the nerve terminal. The protein encoded by this gene is an abundant integral membrane protein of cholinergic synaptic vesicles and is thought to be involved in vesicular transport. It belongs to the quinone oxidoreductase subfamily of zinc-containing alcohol dehydrogenase proteins. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | P-value |
|---|---|---|
| atypical teratoid / rhabdoid tumor | 5112 | 2.4e-09 |
| posterior fossa group A ependymoma | 468 | 9.2e-06 |
| medulloblastoma, large-cell | 6241 | 1.8e-05 |
| primitive neuroectodermal tumor | 3035 | 1.9e-04 |
| Astrocytoma, Pilocytic | 3081 | 2.9e-04 |
| osteosarcoma | 7950 | 4.2e-04 |
| astrocytoma | 1146 | 5.5e-04 |
| glioblastoma | 5792 | 7.0e-04 |
| breast carcinoma | 1638 | 8.6e-04 |
| subependymal giant cell astrocytoma | 2287 | 1.2e-03 |
| group 4 medulloblastoma | 1855 | 2.7e-03 |
| adult high grade glioma | 3801 | 6.9e-03 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Immature cataract | 3 | 4.579 | 2.3 |
| Disease | log2 FC | p |
|---|---|---|
| adult high grade glioma | 1.100 | 6.9e-03 |
| astrocytoma | 1.500 | 5.5e-04 |
| Astrocytoma, Pilocytic | 1.100 | 2.9e-04 |
| atypical teratoid / rhabdoid tumor | 1.600 | 2.4e-09 |
| breast carcinoma | -1.100 | 8.6e-04 |
| glioblastoma | 1.300 | 7.0e-04 |
| group 4 medulloblastoma | 1.300 | 2.7e-03 |
| medulloblastoma, large-cell | 1.400 | 1.8e-05 |
| osteosarcoma | -1.376 | 4.2e-04 |
| posterior fossa group A ependymoma | 1.100 | 9.2e-06 |
| primitive neuroectodermal tumor | 1.400 | 1.9e-04 |
| subependymal giant cell astrocytoma | 2.237 | 1.2e-03 |
| Species | Source | Disease |
|---|---|---|
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG |
MSDEREVAEAATGEDASSPPPKTEAASDPQHPAASEGAAAAAASPPLLRCLVLTGFGGYDKVKLQSRPAA 1 - 70 PPAPGPGQLTLRLRACGLNFADLMARQGLYDRLPPLPVTPGMEGAGVVIAVGEGVSDRKAGDRVMVLNRS 71 - 140 GMWQEEVTVPSVQTFLIPEAMTFEEAAALLVNYITAYMVLFDFGNLQPGHSVLVHMAAGGVGMAAVQLCR 141 - 210 TVENVTVFGTASASKHEALKENGVTHPIDYHTTDYVDEIKKISPKGVDIVMDPLGGSDTAKGYNLLKPMG 211 - 280 KVVTYGMANLLTGPKRNLMALARTWWNQFSVTALQLLQANRAVCGFHLGYLDGEVELVSGVVARLLALYN 281 - 350 QGHIKPHIDSVWPFEKVADAMKQMQEKKNVGKVLLVPGPEKEN 351 - 393 //
