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Tbio
USP53
Inactive ubiquitin carboxyl-terminal hydrolase 53

Protein Summary
Description
Tight junction-associated protein that is involved in the survival of auditory hair cells and hearing. Maybe by modulating the barrier properties and mechanical stability of tight junctions (By similarity). Has no peptidase activity (PubMed:14715245).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000274030
  • ENSP00000274030
  • ENSG00000145390
  • ENST00000450251
  • ENSP00000409906

Symbol
  • KIAA1350
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.8
transcription factor binding site profile
0.71
virus perturbation
0.68
cell type or tissue
0.67
transcription factor
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.5   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 92   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.5   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 92   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0