| Tbio | Ubiquitin carboxyl-terminal hydrolase 22 |
Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation and cell cycle progression.
Comments
| Disease | Target Count | P-value |
|---|---|---|
| juvenile dermatomyositis | 1187 | 9.8e-13 |
| lung carcinoma | 2843 | 1.6e-04 |
| ovarian cancer | 8520 | 1.7e-04 |
| Multiple myeloma | 1332 | 2.8e-04 |
| diabetes mellitus | 1728 | 1.0e-03 |
| acute myeloid leukemia | 783 | 1.9e-02 |
| astrocytoma | 1146 | 2.4e-02 |
| Disease | log2 FC | p |
|---|---|---|
| acute myeloid leukemia | 1.500 | 1.9e-02 |
| astrocytoma | 1.100 | 2.4e-02 |
| diabetes mellitus | 2.500 | 1.0e-03 |
| juvenile dermatomyositis | 1.124 | 9.8e-13 |
| lung carcinoma | 1.100 | 1.6e-04 |
| Multiple myeloma | 1.133 | 2.8e-04 |
| ovarian cancer | -1.100 | 1.7e-04 |
MVSRPEPEGEAMDAELAVAPPGCSHLGSFKVDNWKQNLRAIYQCFVWSGTAEARKRKAKSCICHVCGVHL 1 - 70 NRLHSCLYCVFFGCFTKKHIHEHAKAKRHNLAIDLMYGGIYCFLCQDYIYDKDMEIIAKEEQRKAWKMQG 71 - 140 VGEKFSTWEPTKRELELLKHNPKRRKITSNCTIGLRGLINLGNTCFMNCIVQALTHTPLLRDFFLSDRHR 141 - 210 CEMQSPSSCLVCEMSSLFQEFYSGHRSPHIPYKLLHLVWTHARHLAGYEQQDAHEFLIAALDVLHRHCKG 211 - 280 DDNGKKANNPNHCNCIIDQIFTGGLQSDVTCQVCHGVSTTIDPFWDISLDLPGSSTPFWPLSPGSEGNVV 281 - 350 NGESHVSGTTTLTDCLRRFTRPEHLGSSAKIKCSGCHSYQESTKQLTMKKLPIVACFHLKRFEHSAKLRR 351 - 420 KITTYVSFPLELDMTPFMASSKESRMNGQYQQPTDSLNNDNKYSLFAVVNHQGTLESGHYTSFIRQHKDQ 421 - 490 WFKCDDAIITKASIKDVLDSEGYLLFYHKQFLEYE 491 - 525 //
