UQCC3
Ubiquinol-cytochrome-c reductase complex assembly factor 3
Protein Summary
Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex), mediating cytochrome b recruitment and probably stabilization within the complex. Thereby, plays an important role in ATP production by mitochondria. Cardiolipin-binding protein, it may also control the cardiolipin composition of mitochondria membranes and their morphology. Complex III is a mitochondrial inner membrane protein complex that transfers electrons from ubiquinol to cytochrome c. This gene encodes a protein that functions in complex III assembly. Mutations in this gene result in Mitochondrial complex III deficiency, nuclear type 9. [provided by RefSeq, Dec 2014]
- ENST00000377953
- ENSP00000367189
- ENSG00000204922
- ENST00000531323
- ENSP00000432692
- C11orf83
- MC3DN9
- UNQ655
- C11orf83
- CCDS41658.1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.78 | ||
tissue sample | 0.57 | ||
transcription factor binding site profile | 0.56 | ||
cell line | 0.45 | ||
transcription factor | 0.45 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 6.42 (req: < 5)
Gene RIFs: 6 (req: <= 3)
Antibodies: 8 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 6.42 (req: >= 5)
Gene RIFs: 6 (req: > 3)
Antibodies: 8 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0