UQCC1
Ubiquinol-cytochrome-c reductase complex assembly factor 1
Protein Summary
Required for the assembly of the ubiquinol-cytochrome c reductase complex (mitochondrial respiratory chain complex III or cytochrome b-c1 complex). Involved in cytochrome b translation and/or stability. This gene encodes a transmembrane protein that is structurally similar to the mouse basic fibroblast growth factor repressed ZIC-binding protein. In mouse this protein may be involved in fibroblast growth factor regulated growth control. In humans, polymorphisms in this gene are associated with variation in human height and osteoarthritis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
- ENST00000349714
- ENSP00000335364
- ENSG00000101019
- ENST00000374380
- ENSP00000363501
- ENST00000374384
- ENSP00000363505
- ENST00000374385
- ENSP00000363506
- BZFB
- C20orf44
- UQCC
- BFZB
- CBP3
- UQCC
- C20orf44
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
histone modification site profile | 0.9 | ||
transcription factor perturbation | 0.8 | ||
cell type or tissue | 0.78 | ||
transcription factor binding site profile | 0.69 | ||
transcription factor | 0.66 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 38.6 (req: < 5)
Gene RIFs: 15 (req: <= 3)
Antibodies: 25 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 38.6 (req: >= 5)
Gene RIFs: 15 (req: > 3)
Antibodies: 25 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 2
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0