Tbio UPF2 Regulator of nonsense transcripts 2

Protein Summary

Description

Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons by associating with the nuclear exon junction complex (EJC). Recruited by UPF3B associated with the EJC core at the cytoplasmic side of the nuclear envelope and the subsequent formation of an UPF1-UPF2-UPF3 surveillance complex (including UPF1 bound to release factors at the stalled ribosome) is believed to activate NMD. In cooperation with UPF3B stimulates both ATPase and RNA helicase activities of UPF1. Binds spliced mRNA. This gene encodes a protein that is part of a post-splicing multiprotein complex involved in both mRNA nuclear export and mRNA surveillance. mRNA surveillance detects exported mRNAs with truncated open reading frames and initiates nonsense-mediated mRNA decay (NMD). When translation ends upstream from the last exon-exon junction, this triggers NMD to degrade mRNAs containing premature stop codons. This protein is located in the perinuclear area. It interacts with translation release factors and the proteins that are functional homologs of yeast Upf1p and Upf3p. Two splice variants have been found for this gene; both variants encode the same protein. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• Q9HAU5
• A6NLJ5
• D3DRS0
• Q14BM1
• Q5W0J4
• Q8N8U1
• Q9H1J2
• Q9NWL1
• Q9P2D9
• Q9Y4M9

Gene Name

• UPF2

Ensembl ID

• ENST00000356352
• ENSP00000348708
• ENSG00000151461
• ENST00000357604
• ENSP00000350221
• ENST00000397053
• ENSP00000380244

Symbol

• KIAA1408
• RENT2
• HUPF2
• RENT2
• smg-3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.99
interacting protein	0.94
disease perturbation	0.87
histone modification site profile	0.67
transcription factor	0.67

Protein Classes

PANTHER Classes

Protein / Nucleic Acid Binding / Nuclease / Regulator Of Nonsense Transcripts 2

DTO Classes

Protein / Enzyme / Nuclease / Regulator Of Nonsense Transcripts 2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 92.72   (req: < 5)

Gene RIFs: 18   (req: <= 3)

Antibodies: 154   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 92.72   (req: >= 5)

Gene RIFs: 18   (req: > 3)

Antibodies: 154   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0