| Tbio | Uracil-DNA glycosylase |
Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
This gene encodes one of several uracil-DNA glycosylases. One important function of uracil-DNA glycosylases is to prevent mutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosylic bond and initiating the base-excision repair (BER) pathway. Uracil bases occur from cytosine deamination or misincorporation of dUMP residues. Alternative promoter usage and splicing of this gene leads to two different isoforms: the mitochondrial UNG1 and the nuclear UNG2. The UNG2 term was used as a previous symbol for the CCNO gene (GeneID 10309), which has been confused with this gene, in the literature and some databases. [provided by RefSeq, Nov 2010]
This gene encodes one of several uracil-DNA glycosylases. One important function of uracil-DNA glycosylases is to prevent mutagenesis by eliminating uracil from DNA molecules by cleaving the N-glycosylic bond and initiating the base-excision repair (BER) pathway. Uracil bases occur from cytosine deamination or misincorporation of dUMP residues. Alternative promoter usage and splicing of this gene leads to two different isoforms: the mitochondrial UNG1 and the nuclear UNG2. The UNG2 term was used as a previous symbol for the CCNO gene (GeneID 10309), which has been confused with this gene, in the literature and some databases. [provided by RefSeq, Nov 2010]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Bloom syndrome | 29 | 0.0 | 0.0 |
| Colorectal Neoplasms | 243 | 0.0 | 0.0 |
| Hyper-IgM Immunodeficiency Syndrome | 3 | 0.0 | 0.0 |
| Disease | Target Count | P-value |
|---|---|---|
| non-small cell lung cancer | 2890 | 3.1e-17 |
| nasopharyngeal carcinoma | 1058 | 6.8e-05 |
| medulloblastoma, large-cell | 6241 | 1.1e-04 |
| osteosarcoma | 7950 | 1.1e-04 |
| ovarian cancer | 8520 | 1.2e-04 |
| group 3 medulloblastoma | 4104 | 3.1e-04 |
| lung cancer | 4740 | 8.4e-04 |
| acute myeloid leukemia | 783 | 3.8e-02 |
| Disease | Target Count |
|---|---|
| Immunodeficiency with hyper IgM type 5 | 1 |
| Disease | log2 FC | p |
|---|---|---|
| acute myeloid leukemia | -1.800 | 3.8e-02 |
| group 3 medulloblastoma | 1.500 | 3.1e-04 |
| lung cancer | 2.000 | 8.4e-04 |
| medulloblastoma, large-cell | 1.100 | 1.1e-04 |
| nasopharyngeal carcinoma | 1.100 | 6.8e-05 |
| non-small cell lung cancer | 1.230 | 3.1e-17 |
| osteosarcoma | -1.839 | 1.1e-04 |
| ovarian cancer | 1.900 | 1.2e-04 |
MIGQKTLYSFFSPSPARKRHAPSPEPAVQGTGVAGVPEESGDAAAIPAKKAPAGQEEPGTPPSSPLSAEQ 1 - 70 LDRIQRNKAAALLRLAARNVPVGFGESWKKHLSGEFGKPYFIKLMGFVAEERKHYTVYPPPHQVFTWTQM 71 - 140 CDIKDVKVVILGQDPYHGPNQAHGLCFSVQRPVPPPPSLENIYKELSTDIEDFVHPGHGDLSGWAKQGVL 141 - 210 LLNAVLTVRAHQANSHKERGWEQFTDAVVSWLNQNSNGLVFLLWGSYAQKKGSAIDRKRHHVLQTAHPSP 211 - 280 LSVYRGFFGCRHFSKTNELLQKSGKKPIDWKEL 281 - 313 //
