Tbio ULBP3 UL16-binding protein 3

Protein Summary

Description

Binds and activates the KLRK1/NKG2D receptor, mediating natural killer cell cytotoxicity. The protein encoded by this gene is one of several related ligands of the KLRK1/NKG2D receptor, which is found in primary NK cells. Binding of these ligands to the receptor activates several signal transduction pathways, including the JAK2, STAT5, and ERK pathways. The encoded protein is expressed solubly and on the surface of many tumor cells, making it potentially an important target for therapeutics. [provided by RefSeq, Nov 2015]

Uniprot Accession IDs

• Q9BZM4
• Q5VY82
• Q8IZX5
• Q8TE75

Gene Name

• ULBP3

Ensembl ID

• ENST00000367339
• ENSP00000356308
• ENSG00000131019
• ENST00000438272
• ENSP00000403562

Symbol

• N2DL3
• RAET1N
• N2DL-3
• RAET1N
• NKG2DL3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.68
tissue sample	0.56
cell line	0.48
disease	0.47
tissue	0.46

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.86   (req: < 5)

Gene RIFs: 16   (req: <= 3)

Antibodies: 127   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 23.86   (req: >= 5)

Gene RIFs: 16   (req: > 3)

Antibodies: 127   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0