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Tbio
UGT1A8
UDP-glucuronosyltransferase 1-8

Protein Summary
Description
UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. Isoform 2 lacks transferase activity but acts as a negative regulator of isoform 1. This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5' exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has glucuronidase activity with many sub ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373450
  • ENSP00000362549
  • ENSG00000242366

Symbol
  • GNT1
  • UGT1
  • GNT1
  • UGT1
  • UDPGT
  • UGT1A
  • UGT1H
  • UGT-1A
  • UGT-1H
  • UGT1.1
  • UGT1.8
  • UGT1A1
  • UGT1-01
  • UGT1-08
  • UGT1A8S
  • hUG-BR1
  • UDPGT 1-8
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.97
chemical
0.96
molecular function
0.91
cell type or tissue
0.88
disease
0.65


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 931.96   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 5   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 931.96   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 5   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0