| Tbio | Mitochondrial uncoupling protein 2 |
UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat.
Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed in many tissues, with the greatest expression in skeletal muscle. It is thought to play a role in nonshivering thermogenesis, obesity and diabetes. Chromosomal order is 5'-UCP3-UCP2-3'. [provided by RefSeq, Jul 2008]
Mitochondrial uncoupling proteins (UCP) are members of the larger family of mitochondrial anion carrier proteins (MACP). UCPs separate oxidative phosphorylation from ATP synthesis with energy dissipated as heat, also referred to as the mitochondrial proton leak. UCPs facilitate the transfer of anions from the inner to the outer mitochondrial membrane and the return transfer of protons from the outer to the inner mitochondrial membrane. They also reduce the mitochondrial membrane potential in mammalian cells. Tissue specificity occurs for the different UCPs and the exact methods of how UCPs transfer H+/OH- are not known. UCPs contain the three homologous protein domains of MACPs. This gene is expressed in many tissues, with the greatest expression in skeletal muscle. It is thought to play a role in nonshivering thermogenesis, obesity and diabetes. Chromosomal order is 5'-UCP3-UCP2-3'. [provided by RefSeq, Jul 2008]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Obesity | 678 | 5.877 | 2.9 |
| BODY MASS INDEX QUANTITATIVE TRAIT LOCUS 4 | 1 | 0.0 | 0.0 |
| Brain Injuries | 65 | 0.0 | 0.0 |
| Brain Ischemia | 110 | 0.0 | 0.0 |
| Carcinoma | 11493 | 0.0 | 0.0 |
| Cardiomegaly | 116 | 0.0 | 0.0 |
| Diabetes Mellitus, Experimental | 108 | 0.0 | 0.0 |
| Diabetes Mellitus, Type 2 | 142 | 0.0 | 0.0 |
| Fatty Liver | 70 | 0.0 | 0.0 |
| Hypertension | 396 | 0.0 | 0.0 |
| Mammary Neoplasms, Animal | 136 | 0.0 | 0.0 |
| Mammary Neoplasms, Experimental | 154 | 0.0 | 0.0 |
| Stroke | 33 | 0.0 | 0.0 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Hyperinsulinemic hypoglycemia | 17 | 0.0 | 5.0 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| diabetes mellitus | 1728 | 5.008 | 2.5 |
| Hyperglycemia | 137 | 4.017 | 2.0 |
| Vascular disease | 319 | 3.821 | 1.9 |
| Fatty liver disease | 103 | 3.64 | 1.8 |
| Hyperinsulinism | 133 | 3.61 | 1.8 |
| Disease | Target Count |
|---|---|
| Hyperinsulinism due to UCP2 deficiency | 1 |
MVGFKATDVPPTATVKFLGAGTAACIADLITFPLDTAKVRLQIQGESQGPVRATASAQYRGVMGTILTMV 1 - 70 RTEGPRSLYNGLVAGLQRQMSFASVRIGLYDSVKQFYTKGSEHASIGSRLLAGSTTGALAVAVAQPTDVV 71 - 140 KVRFQAQARAGGGRRYQSTVNAYKTIAREEGFRGLWKGTSPNVARNAIVNCAELVTYDLIKDALLKANLM 141 - 210 TDDLPCHFTSAFGAGFCTTVIASPVDVVKTRYMNSALGQYSSAGHCALTMLQKEGPRAFYKGFMPSFLRL 211 - 280 GSWNVVMFVTYEQLKRALMAACTSREAPF 281 - 309 //
