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Tbio
UBP1
Upstream-binding protein 1

Protein Summary
Description
Functions as a transcriptional activator in a promoter context-dependent manner. Modulates the placental expression of CYP11A1. Involved in regulation of the alpha-globin gene in erythroid cells. Activation of the alpha-globin promoter in erythroid cells is via synergistic interaction with TFCP2 (By similarity). Involved in regulation of the alpha-globin gene in erythroid cells. Binds strongly to sequences around the HIV-1 initiation site and weakly over the TATA-box. Represses HIV-1 transcription by inhibiting the binding of TFIID to the TATA-box.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000283628
  • ENSP00000283628
  • ENSG00000153560
  • ENST00000283629
  • ENSP00000283629
  • ENST00000447368
  • ENSP00000395558

Symbol
  • LBP1
  • LBP1A
  • LBP1B
  • LBP-1B
  • LBP-1a
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.88
transcription factor binding site profile
0.86
transcription factor perturbation
0.74
hub protein
0.71
transcription factor
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 100.73   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 271   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 100.73   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 271   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0