Property Summary

NCBI Gene PubMed Count 20
PubMed Score 7.01
PubTator Score 10.05

Knowledge Summary


No data available


  Differential Expression (15)

Disease log2 FC p
Rheumatoid Arthritis 2.500 1.1e-02
astrocytic glioma -2.200 4.4e-02
oligodendroglioma -2.100 4.9e-02
osteosarcoma -2.333 1.7e-06
atypical teratoid / rhabdoid tumor -2.100 3.8e-06
glioblastoma -1.700 5.1e-05
medulloblastoma -1.800 2.4e-05
medulloblastoma, large-cell -2.100 5.1e-04
primitive neuroectodermal tumor -1.300 1.3e-03
juvenile dermatomyositis 1.057 3.9e-08
acute quadriplegic myopathy 1.253 5.2e-05
Breast cancer 2.400 3.4e-02
adult high grade glioma -1.200 1.1e-02
invasive ductal carcinoma 1.200 1.2e-03
ovarian cancer 1.400 4.2e-03

Protein-protein Interaction (2)

Gene RIF (5)

26101372 TRIM5alpha requires Ube2W to anchor Lys63-linked ubiquitin chains and restrict reverse transcription.
25436519 We show the ubequitin-conjugating enzyme (E2) Ube2w uses a unique mechanism to facilitate the specific ubiquitination of the alpha-amino group
23696636 Ube2w has novel enzymatic properties that direct ubiquitination of the N terminus of substrates
21229326 UBE2W regulates FANCD2 monoubiquitination by mechanisms different from UBE2T and HRR6.
16368532 human Ubiquitin-conjugating enzyme (E2) is homologous to the Arabidopsis thaliana UBC-16 gene product and contains 2 nuclear localization signals

AA Sequence

KTKWWYHDDTC                                                               141 - 151

Text Mined References (23)

PMID Year Title
26101372 2015 TRIM5? requires Ube2W to anchor Lys63-linked ubiquitin chains and restrict reverse transcription.
25436519 2015 Intrinsic disorder drives N-terminal ubiquitination by Ube2w.
25416956 2014 A proteome-scale map of the human interactome network.
23696636 2013 The ubiquitin-conjugating enzyme (E2) Ube2w ubiquitinates the N terminus of substrates.
23560854 2013 Ube2W conjugates ubiquitin to ?-amino groups of protein N-termini.
22496338 2012 A human ubiquitin conjugating enzyme (E2)-HECT E3 ligase structure-function screen.
22157707 2011 Profiling of autoantibodies in IgA nephropathy, an integrative antibiomics approach.
21855799 2011 Ube2w and ataxin-3 coordinately regulate the ubiquitin ligase CHIP.
21516116 2011 Next-generation sequencing to generate interactome datasets.
21229326 2011 UBE2W interacts with FANCL and regulates the monoubiquitination of Fanconi anemia protein FANCD2.
20061386 2010 The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines.
19851334 2009 Building ubiquitin chains: E2 enzymes at work.
19690564 2009 A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system.
19549727 2009 Analysis of the human E2 ubiquitin conjugating enzyme protein interaction network.
19111657 2008 Mechanistic insight into site-restricted monoubiquitination of FANCD2 by Ube2t, FANCL, and FANCI.
17873885 2007 E2-BRCA1 RING interactions dictate synthesis of mono- or specific polyubiquitin chain linkages.
16421571 2006 DNA sequence and analysis of human chromosome 8.
16368532 2006 Cloning, characterization and subcellular localization of a gene encoding a human Ubiquitin-conjugating enzyme (E2) homologous to the Arabidopsis thaliana UBC-16 gene product.
16344560 2006 Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
8125298 1994 Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.