Tbio UBE2F NEDD8-conjugating enzyme UBE2F

Protein Summary

Description

Accepts the ubiquitin-like protein NEDD8 from the UBA3-NAE1 E1 complex and catalyzes its covalent attachment to other proteins. The specific interaction with the E3 ubiquitin ligase RBX2, but not RBX1, suggests that the RBX2-UBE2F complex neddylates specific target proteins, such as CUL5.

Uniprot Accession IDs

• Q969M7
• A8K1Z8
• B4DDT9
• B4DFI1
• B4DMK3
• B4DZU2
• B8ZZG2
• C9J212
• H9KVB9

Gene Name

• UBE2F

Ensembl ID

• ENST00000272930
• ENSP00000272930
• ENSG00000184182
• ENST00000409633
• ENSP00000387299
• ENST00000409953
• ENSP00000386680
• ENST00000414443
• ENSP00000399183
• ENST00000433241
• ENSP00000393515
• ENST00000441728
• ENSP00000409749
• ENST00000612130
• ENSP00000478474

Symbol

• NCE2
• NCE2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	1
molecular function	0.96
transcription factor binding site profile	0.93
disease perturbation	0.9
virus perturbation	0.88

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.67   (req: < 5)

Gene RIFs: 6   (req: <= 3)

Antibodies: 208   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.67   (req: >= 5)

Gene RIFs: 6   (req: > 3)

Antibodies: 208   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0