| Tbio | Ubiquitin-conjugating enzyme E2 E2 |
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-, as well as 'Lys-63'-linked polyubiquitination. Catalyzes the ISGylation of influenza A virus NS1 protein.
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Adenoma, Liver Cell | 8 | 0.0 | 0.0 |
| Carcinoma, Hepatocellular | 228 | 0.0 | 0.0 |
| Diabetes Mellitus, Type 2 | 142 | 0.0 | 0.0 |
| Disease | Target Count |
|---|---|
| Diabetes Mellitus, Non-Insulin-Dependent | 145 |
| Disease | Target Count | P-value |
|---|---|---|
| acute quadriplegic myopathy | 1158 | 4.5e-08 |
| tuberculosis | 2010 | 4.5e-07 |
| atypical teratoid / rhabdoid tumor | 5112 | 2.0e-05 |
| intraductal papillary-mucinous adenoma (IPMA) | 2955 | 6.5e-05 |
| ovarian cancer | 8520 | 8.7e-05 |
| ependymoma | 4679 | 1.8e-04 |
| Breast cancer | 3578 | 2.9e-04 |
| glioblastoma | 5792 | 4.4e-04 |
| intraductal papillary-mucinous carcinoma (IPMC) | 2989 | 7.8e-04 |
| pituitary cancer | 1972 | 1.2e-03 |
| pancreatic cancer | 2398 | 1.5e-03 |
| ulcerative colitis | 1819 | 6.8e-03 |
| group 3 medulloblastoma | 4104 | 9.1e-03 |
| medulloblastoma, large-cell | 6241 | 9.6e-03 |
| primitive neuroectodermal tumor | 3035 | 1.2e-02 |
| pancreatic ductal adenocarcinoma liver metastasis | 1962 | 1.3e-02 |
| astrocytic glioma | 2597 | 2.5e-02 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 3.2e-02 |
| invasive ductal carcinoma | 2951 | 3.4e-02 |
| acute myeloid leukemia | 783 | 4.5e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Kidney disease | 430 | 0.0 | 1.4 |
| Disease | log2 FC | p |
|---|---|---|
| acute myeloid leukemia | 2.200 | 4.5e-02 |
| acute quadriplegic myopathy | 1.712 | 4.5e-08 |
| astrocytic glioma | -1.300 | 2.5e-02 |
| atypical teratoid / rhabdoid tumor | -2.200 | 2.0e-05 |
| Breast cancer | -1.300 | 2.9e-04 |
| ependymoma | -1.300 | 1.8e-04 |
| glioblastoma | -1.200 | 4.4e-04 |
| group 3 medulloblastoma | -2.100 | 9.1e-03 |
| intraductal papillary-mucinous adenoma (... | -1.900 | 6.5e-05 |
| intraductal papillary-mucinous carcinoma... | -2.000 | 7.8e-04 |
| intraductal papillary-mucinous neoplasm ... | -1.400 | 3.2e-02 |
| invasive ductal carcinoma | -1.100 | 3.4e-02 |
| medulloblastoma, large-cell | -1.600 | 9.6e-03 |
| ovarian cancer | -1.300 | 8.7e-05 |
| pancreatic cancer | 1.300 | 1.5e-03 |
| pancreatic ductal adenocarcinoma liver m... | -1.032 | 1.3e-02 |
| pituitary cancer | -1.600 | 1.2e-03 |
| primitive neuroectodermal tumor | -1.400 | 1.2e-02 |
| tuberculosis | 1.100 | 4.5e-07 |
| ulcerative colitis | 1.100 | 6.8e-03 |
