| Tbio | Ubiquitin-conjugating enzyme E2 E1 |
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes the covalent attachment of ISG15 to other proteins. Mediates the selective degradation of short-lived and abnormal proteins. In vitro also catalyzes 'Lys-48'-linked polyubiquitination.
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Three alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Arsenic Poisoning | 62 | 0.0 | 0.0 |
| Arthritis, Juvenile | 126 | 0.0 | 0.0 |
| Skin Diseases | 71 | 0.0 | 0.0 |
| Disease | Target Count |
|---|---|
| Dermatologic disorders | 93 |
| Juvenile arthritis | 126 |
| Disease | Target Count | P-value |
|---|---|---|
| Amyotrophic lateral sclerosis | 451 | 3.0e-06 |
| acute quadriplegic myopathy | 1158 | 6.3e-05 |
| Multiple myeloma | 1332 | 1.0e-04 |
| lung cancer | 4740 | 2.1e-03 |
| ovarian cancer | 8520 | 3.3e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Spinocerebellar ataxia type 1 | 16 | 4.407 | 2.2 |
| UV-sensitive syndrome | 10 | 4.288 | 2.1 |
| Autosomal recessive limb-girdle muscular dystrophy type 2H | 7 | 3.714 | 1.9 |
| Disease | log2 FC | p |
|---|---|---|
| acute quadriplegic myopathy | 1.150 | 6.3e-05 |
| Amyotrophic lateral sclerosis | 1.063 | 3.0e-06 |
| lung cancer | 1.400 | 2.1e-03 |
| Multiple myeloma | 1.712 | 1.0e-04 |
| ovarian cancer | 1.300 | 3.3e-02 |
