Tbio TUSC2 Tumor suppressor candidate 2

Protein Summary

Description

May function as a tumor suppressor, inhibiting colony formation, causing G1 arrest and ultimately inducing apoptosis in homozygous 3p21.3 120-kb region-deficient cells. This gene is a highly conserved lung cancer candidate gene. No other information about this gene is currently available. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• O75896
• B2R4Y9

Gene Name

• TUSC2

Ensembl ID

• ENST00000232496
• ENSP00000232496
• ENSG00000114383

Symbol

• C3orf11
• FUS1
• LGCC
• PDAP2
• PAP
• FUS1
• PDAP2
• C3orf11

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.96
disease perturbation	0.79
phenotype	0.79
cell type or tissue	0.77
biological process	0.71

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.24   (req: < 5)

Gene RIFs: 20   (req: <= 3)

Antibodies: 174   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 33.24   (req: >= 5)

Gene RIFs: 20   (req: > 3)

Antibodies: 174   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0