| Tclin | Tubulin beta-2A chain |
Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).
Microtubules, key participants in processes such as mitosis and intracellular transport, are composed of heterodimers of alpha- and beta-tubulins. The protein encoded by this gene is a beta-tubulin. Defects in this gene are associated with complex cortical dysplasia with other brain malformations-5. Two transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2015]
Microtubules, key participants in processes such as mitosis and intracellular transport, are composed of heterodimers of alpha- and beta-tubulins. The protein encoded by this gene is a beta-tubulin. Defects in this gene are associated with complex cortical dysplasia with other brain malformations-5. Two transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2015]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Arthritis, Juvenile | 126 | 0.0 | 0.0 |
| CORTICAL DYSPLASIA, COMPLEX, WITH OTHER BRAIN MALFORMATIONS 5 | 1 | 0.0 | 0.0 |
| Creutzfeldt-Jakob Syndrome | 10 | 0.0 | 0.0 |
| Leukemia, Myeloid, Acute | 105 | 0.0 | 0.0 |
| Disease | Target Count | P-value |
|---|---|---|
| juvenile dermatomyositis | 1187 | 9.8e-11 |
| Duchenne muscular dystrophy | 601 | 1.1e-07 |
| Astrocytoma, Pilocytic | 3081 | 8.3e-07 |
| hepatocellular carcinoma | 547 | 2.0e-06 |
| medulloblastoma, large-cell | 6241 | 3.7e-05 |
| fascioscapulohumeral muscular dystrophy | 100 | 4.7e-04 |
| limb girdle muscular dystrophy 2A | 213 | 6.6e-04 |
| Amyotrophic lateral sclerosis | 451 | 7.2e-04 |
| psoriasis | 6694 | 9.6e-04 |
| dermatomyositis | 966 | 1.6e-03 |
| interstitial cystitis | 2312 | 1.9e-03 |
| nasopharyngeal carcinoma | 1058 | 3.5e-03 |
| ovarian cancer | 8520 | 4.2e-03 |
| autosomal dominant Emery-Dreifuss muscular dystrophy | 510 | 6.2e-03 |
| pancreatic carcinoma | 562 | 6.6e-03 |
| pancreatic cancer | 2398 | 6.6e-03 |
| astrocytic glioma | 2597 | 7.9e-03 |
| acute quadriplegic myopathy | 1158 | 8.5e-03 |
| gastric cancer | 459 | 9.0e-03 |
| Becker muscular dystrophy | 191 | 9.6e-03 |
| atypical teratoid / rhabdoid tumor | 5112 | 1.1e-02 |
| Pick disease | 1894 | 1.2e-02 |
| oligodendroglioma | 2850 | 3.4e-02 |
| ependymoma | 4679 | 3.6e-02 |
| active ulcerative colitis | 764 | 4.7e-02 |
| Disease | log2 FC | p |
|---|---|---|
| active ulcerative colitis | 2.220 | 4.7e-02 |
| acute quadriplegic myopathy | 1.219 | 8.5e-03 |
| Amyotrophic lateral sclerosis | 1.300 | 7.2e-04 |
| astrocytic glioma | -1.900 | 7.9e-03 |
| Astrocytoma, Pilocytic | -1.100 | 8.3e-07 |
| atypical teratoid / rhabdoid tumor | -1.600 | 1.1e-02 |
| autosomal dominant Emery-Dreifuss muscul... | 1.834 | 6.2e-03 |
| Becker muscular dystrophy | 1.731 | 9.6e-03 |
| dermatomyositis | 2.000 | 1.6e-03 |
| Duchenne muscular dystrophy | 2.219 | 1.1e-07 |
| ependymoma | -1.500 | 3.6e-02 |
| fascioscapulohumeral muscular dystrophy | 1.407 | 4.7e-04 |
| gastric cancer | -1.300 | 9.0e-03 |
| hepatocellular carcinoma | -2.100 | 2.0e-06 |
| interstitial cystitis | 1.200 | 1.9e-03 |
| juvenile dermatomyositis | 2.093 | 9.8e-11 |
| limb girdle muscular dystrophy 2A | 1.381 | 6.6e-04 |
| medulloblastoma, large-cell | -1.800 | 3.7e-05 |
| nasopharyngeal carcinoma | -1.700 | 3.5e-03 |
| oligodendroglioma | -1.400 | 3.4e-02 |
| ovarian cancer | -1.700 | 4.2e-03 |
| pancreatic cancer | -1.900 | 6.6e-03 |
| pancreatic carcinoma | -1.900 | 6.6e-03 |
| Pick disease | -1.300 | 1.2e-02 |
| psoriasis | 1.600 | 9.6e-04 |
MREIVHIQAGQCGNQIGAKFWEVISDEHGIDPTGSYHGDSDLQLERINVYYNEAAGNKYVPRAILVDLEP 1 - 70 GTMDSVRSGPFGQIFRPDNFVFGQSGAGNNWAKGHYTEGAELVDSVLDVVRKESESCDCLQGFQLTHSLG 71 - 140 GGTGSGMGTLLISKIREEYPDRIMNTFSVMPSPKVSDTVVEPYNATLSVHQLVENTDETYSIDNEALYDI 141 - 210 CFRTLKLTTPTYGDLNHLVSATMSGVTTCLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTSRGSQQ 211 - 280 YRALTVPELTQQMFDSKNMMAACDPRHGRYLTVAAIFRGRMSMKEVDEQMLNVQNKNSSYFVEWIPNNVK 281 - 350 TAVCDIPPRGLKMSATFIGNSTAIQELFKRISEQFTAMFRRKAFLHWYTGEGMDEMEFTEAESNMNDLVS 351 - 420 EYQQYQDATADEQGEFEEEEGEDEA 421 - 445 //
