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  5. Tubulin polyglutamylase TTLL7

Tbio Tubulin polyglutamylase TTLL7

Polyglutamylase which preferentially modifies beta-tubulin (PubMed:25959773). Mediates both ATP-dependent initiation and elongation of polyglutamylation of microtubules (PubMed:25959773). Required for neurite growth; responsible for the strong increase in tubulin polyglutamylation during postnatal neuronal maturation (By similarity).

 Comments

Property Summary

NCBI Gene PubMed Count 11
PubMed Score 11.66
PubTator Score 2.70

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (3)

Disease Target Count Z-score Confidence
Carcinoma 11493 0.0 0.9
Kidney cancer 2613 0.0 0.6
Disease Target Count Z-score Confidence
Alzheimer's disease 658 0.0 1.7

Expression

  Differential Expression (28)

Disease log2 FC p
adult high grade glioma -1.500 3.2e-06
astrocytic glioma -1.500 1.1e-02
Astrocytoma, Pilocytic -1.300 2.5e-06
atypical teratoid / rhabdoid tumor -1.600 9.6e-05
Breast cancer 1.200 4.8e-04
colon cancer -2.100 6.7e-04
cystic fibrosis 2.133 1.4e-05
diabetes mellitus -1.100 3.2e-03
Down syndrome 1.300 4.9e-03
ependymoma -2.400 1.1e-02
glioblastoma -1.100 1.8e-03
group 4 medulloblastoma -1.800 3.4e-07
intraductal papillary-mucinous adenoma (... -1.400 1.4e-04
intraductal papillary-mucinous carcinoma... -1.400 3.3e-02
intraductal papillary-mucinous neoplasm ... -1.200 3.1e-03
invasive ductal carcinoma -1.200 4.1e-02
lung adenocarcinoma -1.900 1.3e-14
lung cancer 1.700 1.2e-02
lung carcinoma 1.200 2.7e-11
malignant mesothelioma -3.800 9.3e-09
medulloblastoma, large-cell -1.400 1.2e-03
non diabetic and post-ischemic heart fai... 1.100 3.9e-02
non-small cell lung carcinoma -2.100 1.1e-36
oligodendroglioma -1.300 2.1e-02
Pick disease -1.600 1.1e-02
primitive neuroectodermal tumor -1.200 8.5e-03
progressive supranuclear palsy -2.200 4.8e-03
urothelial carcinoma -1.300 2.3e-04

Synonym

Accession Q6ZT98 Q5TAX8 Q5TAX9 Q6P990 Q86YS1 Q9H5U4
Symbols

Gene

TTLL7

PANTHER Protein Class (2)

  Ortholog (13)

Species Source Disease
OMA EggNOG
OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid EggNOG
OMA EggNOG
Inparanoid OMA EggNOG

 UniProt Keyword (15)

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 GO Function (4)

 GO Component (5)

 GO Process (3)

 Compartment GO Term (31)

See all...

 GWAS Trait (1)

 HCA RNA Cell Line (52)

See all...

Pathway (3)

Protein-protein Interaction (3)

ZMYM1   CSNK2A2   CSNK2A1  

PDB (2)

AA Sequence 

MPSLPQEGVIQGPSPLDLNTELPYQSTMKRKVRKKKKKGTITANVAGTKFEIVRLVIDEMGFMKTPDEDE      1 - 70
TSNLIWCDSAVQQEKISELQNYQRINHFPGMGEICRKDFLARNMTKMIKSRPLDYTFVPRTWIFPAEYTQ     71 - 140
FQNYVKELKKKRKQKTFIVKPANGAMGHGISLIRNGDKLPSQDHLIVQEYIEKPFLMEGYKFDLRIYILV    141 - 210
TSCDPLKIFLYHDGLVRMGTEKYIPPNESNLTQLYMHLTNYSVNKHNEHFERDETENKGSKRSIKWFTEF    211 - 280
LQANQHDVAKFWSDISELVVKTLIVAEPHVLHAYRMCRPGQPPGSESVCFEVLGFDILLDRKLKPWLLEI    281 - 350
NRAPSFGTDQKIDYDVKRGVLLNALKLLNIRTSDKRRNLAKQKAEAQRRLYGQNSIKRLLPGSSDWEQQR    351 - 420
HQLERRKEELKERLAQVRKQISREEHENRHMGNYRRIYPPEDKALLEKYENLLAVAFQTFLSGRAASFQR    421 - 490
ELNNPLKRMKEEDILDLLEQCEIDDEKLMGKTTKTRGPKPLCSMPESTEIMKRPKYCSSDSSYDSSSSSS    491 - 560
ESDENEKEEYQNKKREKQVTYNLKPSNHYKLIQQPSSIRRSVSCPRSISAQSPSSGDTRPFSAQQMISVS    561 - 630
RPTSASRSHSLNRASSYMRHLPHSNDACSTNSQVSESLRQLKTKEQEDDLTSQTLFVLKDMKIRFPGKSD    631 - 700
AESELLIEDIIDNWKYHKTKVASYWLIKLDSVKQRKVLDIVKTSIRTVLPRIWKVPDVEEVNLYRIFNRV    701 - 770
FNRLLWSRGQGLWNCFCDSGSSWESIFNKSPEVVTPLQLQCCQRLVELCKQCLLVVYKYATDKRGSLSGI    771 - 840
GPDWGNSRYLLPGSTQFFLRTPTYNLKYNSPGMTRSNVLFTSRYGHL                           841 - 887
//

Text Mined References (12)

PMID Year Title