Property Summary

NCBI Gene PubMed Count 16
PubMed Score 2.95
PubTator Score 52.07

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (11)

Disease log2 FC p
psoriasis 1.300 2.9e-03
glioblastoma 1.400 4.7e-05
group 3 medulloblastoma 2.000 1.2e-03
atypical teratoid/rhabdoid tumor 1.500 2.9e-05
medulloblastoma, large-cell 2.700 6.3e-06
primitive neuroectodermal tumor 1.200 4.7e-03
intraductal papillary-mucinous neoplasm ... 1.500 9.1e-03
lung cancer 1.700 7.8e-04
pediatric high grade glioma 1.600 5.4e-05
nasopharyngeal carcinoma 1.100 2.9e-04
ovarian cancer 1.300 9.7e-05

Gene RIF (7)

PMID Text
26356687 Mutations of TTF2 is associated with risk of Papillary Thyroid Cancer in Chinese. Patients with Multiplendular goiter and no metastasis are more likely to suffer PTC. G/A mutation of TTF2 had a high correlation with PTC in the overall population.
23110726 Depletion of transcription termination factor, RNA polymerase II (TTF2) by siRNA enhances HIV-1 Tat activation of HIV-1 LTR, which is not the results of increased Tat expression and release of CDK9/CCNT1 from 7SK snRNP, and activation of NF-kappaB
15467445 Importantly, the mitotic phenotype seen with TTF2-siRNA is rescued by expression of the siRNA-resistant GFP-tagged TTF2 proving that reduced TTF2 is responsible for the retention of RNA polymerase II on mitotic chromosomes.
15320969 Observational study of gene-disease association. (HuGE Navigator)
15125840 TTF2 is the only ATP-dependent termination activity associated with Pol II transcription elongation complexes, is largely unaffected by template position, and is impervious to the phosphorylation state of the polymerase.
12927788 hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing
12165566 Observational study of gene-disease association. (HuGE Navigator)

AA Sequence

MEEVRCPEHGTFCFLKTGVRDGPNKGKSFYVCRADTCSFVRATDIPVSHCLLHEDFVVELQGLLLPQDKK      1 - 70
EYRLFFRCIRSKAEGKRWCGSIPWQDPDSKEHSVSNKSQHASETFHHSSNWLRNPFKVLDKNQEPALWKQ     71 - 140
LIKGEGEEKKADKKQREKGDQLFDQKKEQKPEMMEKDLSSGLVPKKKQSVVQEKKQEEGAEIQCEAETGG    141 - 210
THKRDFSEIKSQQCQGNELTRPSASSQEKSSGKSQDVQRESEPLREKVTQLLPQNVHSHNSISKPQKGGP    211 - 280
LNKEYTNWEAKETKAKDGPSIQATQKSLPQGHFQERPETHSVPAPGGPAAQAAPAAPGLSLGEGREAATS    281 - 350
SDDEEEDDVVFVSSKPGSPLLFDSTLDLETKENLQFPDRSVQRKVSPASGVSKKVEPSDPVARRVYLTTQ    351 - 420
LKQKKSTLASVNIQALPDKGQKLIKQIQELEEVLSGLTLSPEQGTNEKSNSQVPQQSHFTKTTTGPPHLV    421 - 490
PPQPLPRRGTQPVGSLELKSACQVTAGGSSQCYRGHTNQDHVHAVWKITSEAIGQLHRSLESCPGETVVA    491 - 560
EDPAGLKVPLLLHQKQALAWLLWRESQKPQGGILADDMGLGKTLTMIALILTQKNQEKKEEKEKSTALTW    561 - 630
LSKDDSCDFTSHGTLIICPASLIHHWKNEVEKRVNSNKLRVYLYHGPNRDSRARVLSTYDIVITTYSLVA    631 - 700
KEIPTNKQEAEIPGANLNVEGTSTPLLRIAWARIILDEAHNVKNPRVQTSIAVCKLQACARWAVTGTPIQ    701 - 770
NNLLDMYSLLKFLRCSPFDEFNLWRSQVDNGSKKGGERLSILTKSLLLRRTKDQLDSTGRPLVILPQRKF    771 - 840
QLHHLKLSEDEETVYNVFFARSRSALQSYLKRHESRGNQSGRSPNNPFSRVALEFGSEEPRHSEAADSPR    841 - 910
SSTVHILSQLLRLRQCCCHLSLLKSALDPMELKGEGLVLSLEEQLSALTLSELRDSEPSSTVSLNGTFFK    911 - 980
MELFEGMRESTKISSLLAELEAIQRNSASQKSVIVSQWTNMLKVVALHLKKHGLTYATIDGSVNPKQRMD    981 - 1050
LVEAFNHSRGPQVMLISLLAGGVGLNLTGGNHLFLLDMHWNPSLEDQACDRIYRVGQQKDVVIHRFVCEG   1051 - 1120
TVEEKILQLQEKKKDLAKQVLSGSGESVTKLTLADLRVLFGI                               1121 - 1162
//

Text Mined References (21)

PMID Year Title
26356687 2015 Replication and Meta-Analysis of Common Gene Mutations in TTF1 and TTF2 with Papillary Thyroid Cancer.
23186163 2013 Toward a comprehensive characterization of a human cancer cell phosphoproteome.
21269460 2011 Initial characterization of the human central proteome.
20068231 2010 Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
18691976 2008 Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.
18669648 2008 A quantitative atlas of mitotic phosphorylation.
18029348 2008 Toward a confocal subcellular atlas of the human proteome.
17577209 2007 The interactome of the histone gene regulatory factor HiNF-P suggests novel cell cycle related roles in transcriptional control and RNA processing.
16710414 2006 The DNA sequence and biological annotation of human chromosome 1.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
15467445 2004 Rescue of the TTF2 knockdown phenotype with an siRNA-resistant replacement vector.
15320969 2004 Genetic analysis of TTF-2 gene in children with congenital hypothyroidism and cleft palate, congenital hypothyroidism, or isolated cleft palate.
15231748 2004 Functional proteomics mapping of a human signaling pathway.
15125840 2004 Involvement of transcription termination factor 2 in mitotic repression of transcription elongation.
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12927788 2003 hLodestar/HuF2 interacts with CDC5L and is involved in pre-mRNA splicing.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
12165566 2002 A novel loss-of-function mutation in TTF-2 is associated with congenital hypothyroidism, thyroid agenesis and cleft palate.
10455150 1999 Human transcription release factor 2 dissociates RNA polymerases I and II stalled at a cyclobutane thymine dimer.
9748214 1998 A human RNA polymerase II transcription termination factor is a SWI2/SNF2 family member.
1916263 1991 Chromosome tangling and breakage at anaphase result from mutations in lodestar, a Drosophila gene encoding a putative nucleoside triphosphate-binding protein.