Tbio TSSK4 Testis-specific serine/threonine-protein kinase 4

Protein Summary

Description

Serine/threonine kinase which is involved in male germ cell development and in mature sperm function (By similarity). May be involved in the Cre/Creb signaling pathway (By similarity). Phosphorylates CREB1 on 'Ser-133' in vitro and can stimulate Cre/Creb pathway in cells (PubMed:15964553). Phosphorylates CREM on 'Ser-116' in vitro (By similarity). Phosphorylates ODF2 on 'Ser-95' (By similarity). This gene encodes a member of the testis-specific serine/threonine kinase family. The encoded protein is thought to be involved in spermatogenesis via stimulation of the CREB/CRE responsive pathway through phosphorylation of the cAMP responsive element binding protein transcription factor. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]

Uniprot Accession IDs

• Q6SA08
• Q2TA60
• Q6ZNM2
• TSK-4

Gene Name

• TSSK4

Ensembl ID

• ENST00000287913
• ENSP00000287913
• ENSG00000139908
• ENST00000339917
• ENSP00000339179
• ENST00000556621
• ENSP00000452054
• ENST00000643387
• ENSP00000495573
• ENSG00000285140
• ENST00000645264
• ENSP00000496404
• ENST00000645272
• ENSP00000496710

Symbol

• C14orf20
• STK22E
• TSSK5
• TSK4
• TSK-4
• TSSK5
• STK22E
• C14orf20

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.95
protein domain	0.73
tissue sample	0.64
cellular component	0.58
virus perturbation	0.55

Protein Classes

PANTHER Classes

Protein / Transferase / Kinase / Protein Kinase / Non-receptor Serine/threonine Protein Kinase / Testis-specific Serine/threonine-protein Kinase 4

DTO Classes

Protein / Kinase / Protein Kinase / Camk Group / Tssk Family / Testis-specific Serine/threonine-protein Kinase 4

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.51   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 129   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9.51   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 129   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0