Property Summary

NCBI Gene PubMed Count 16
PubMed Score 88.97
PubTator Score 14.19

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (18)

Disease log2 FC p
nephrosclerosis 1.040 2.4e-05
psoriasis -1.100 2.6e-03
ependymoma 1.700 9.1e-06
group 3 medulloblastoma 2.600 5.8e-05
atypical teratoid / rhabdoid tumor 2.200 4.3e-04
glioblastoma 1.300 3.1e-03
primitive neuroectodermal tumor 1.400 4.5e-02
primary pancreatic ductal adenocarcinoma 1.165 4.8e-03
non-small cell lung cancer -1.728 3.2e-17
intraductal papillary-mucinous adenoma (... -1.200 1.1e-04
intraductal papillary-mucinous carcinoma... -1.200 1.4e-03
fibroadenoma -1.200 1.3e-02
pediatric high grade glioma 1.200 5.2e-04
pilocytic astrocytoma 1.400 5.0e-05
lung carcinoma -1.400 8.0e-26
ductal carcinoma in situ -1.600 2.6e-04
invasive ductal carcinoma -1.500 6.3e-03
ovarian cancer -1.900 1.2e-11

Synonym

Accession O14817 Q6IAP6 Tspan-4
Symbols NAG2
NAG-2
TM4SF7
TSPAN-4
TETRASPAN

Gene

  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG

Gene RIF (3)

PMID Text
23383108 A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 downregulates the expression of tetraspanin 4 (TSPAN4) in peptide-treated PBMCs
22236579 TM4SF4/il-TMP has the potential to be biomarker in a hepatocellular carcinoma and plays a crucial role in promotion of cancer cell proliferation
20237496 Observational study of gene-disease association. (HuGE Navigator)

AA Sequence

MARACLQAVKYLMFAFNLLFWLGGCGVLGVGIWLAATQGSFATLSSSFPSLSAANLLIITGAFVMAIGFV      1 - 70
GCLGAIKENKCLLLTFFLLLLLVFLLEATIAILFFAYTDKIDRYAQQDLKKGLHLYGTQGNVGLTNAWSI     71 - 140
IQTDFRCCGVSNYTDWFEVYNATRVPDSCCLEFSESCGLHAPGTWWKAPCYETVKVWLQENLLAVGIFGL    141 - 210
CTALVQILGLTFAMTMYCQVVKADTYCA                                              211 - 238
//

Text Mined References (18)

PMID Year Title
25416956 2014 A proteome-scale map of the human interactome network.
22236579 2012 Human tetraspanin transmembrane 4 superfamily member 4 or intestinal and liver tetraspan membrane protein is overexpressed in hepatocellular carcinoma and accelerates tumor cell growth.
21423176 2011 Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for ?-Pix in negative regulation of focal adhesion maturation.
20237496 2010 New genetic associations detected in a host response study to hepatitis B vaccine.
19159218 2009 Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
16959974 2006 The consensus coding sequences of human breast and colorectal cancers.
16341674 2005 Transcriptome analysis of human gastric cancer.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
14671302 2003 Inferring nonneutral evolution from human-chimp-mouse orthologous gene trios.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
11739647 2001 Complexes of tetraspanins with integrins: more than meets the eye.
11591653 2001 Protein-protein interaction panel using mouse full-length cDNAs.
10741407 2000 CD46 (membrane cofactor protein) associates with multiple beta1 integrins and tetraspans.
10734060 2000 Direct extracellular contact between integrin alpha(3)beta(1) and TM4SF protein CD151.
10229664 1999 Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactions.
9714763 1998 Sequences and expression of six new members of the tetraspanin/TM4SF family.
9360996 1997 NAG-2, a novel transmembrane-4 superfamily (TM4SF) protein that complexes with integrins and other TM4SF proteins.