| Tbio | Thyrotropin subunit beta |
Indispensable for the control of thyroid structure and metabolism.
The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. Thyroid stimulating hormone functions in the control of thyroid structure and metabolism. The protein encoded by this gene is the beta subunit of thyroid stimulating hormone. Mutations in this gene are associated with congenital central and secondary hypothyroidism and Hashimoto's thyroiditis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]
The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. Thyroid stimulating hormone functions in the control of thyroid structure and metabolism. The protein encoded by this gene is the beta subunit of thyroid stimulating hormone. Mutations in this gene are associated with congenital central and secondary hypothyroidism and Hashimoto's thyroiditis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2013]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Hypothyroidism | 122 | 6.367 | 3.2 |
| Bipolar Disorder | 666 | 0.0 | 0.0 |
| Coma | 5 | 0.0 | 0.0 |
| Hypothermia | 12 | 0.0 | 0.0 |
| Hypothyroidism, Congenital, Nongoitrous, 4 | 1 | 0.0 | 0.0 |
| Disease | Target Count | P-value |
|---|---|---|
| psoriasis | 6694 | 2.1e-06 |
| pituitary cancer | 1972 | 1.4e-05 |
| Disease | Target Count |
|---|---|
| Secondary hypothyroidism | 15 |
| Disease | log2 FC | p |
|---|---|---|
| pituitary cancer | -6.000 | 1.4e-05 |
| psoriasis | -1.500 | 2.1e-06 |
