Tchem TRPC3 Short transient receptor potential channel 3

Protein Summary

Description

Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G-protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol 1,4,5-triphosphate receptors (ITPR) with bound IP3. May also be activated by internal calcium store depletion. The protein encoded by this gene is a membrane protein that can form a non-selective channel permeable to calcium and other cations. The encoded protein appears to be induced to form channels by a receptor tyrosine kinase-activated phosphatidylinositol second messenger system and also by depletion of intracellular calcium stores. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Uniprot Accession IDs

• Q13507
• A7VJS1
• E9PCJ9
• O00593
• Q15660
• Q52M35
• Q5G1L5
• TrpC3

Gene Name

• TRPC3

Ensembl ID

• ENST00000264811
• ENSP00000264811
• ENSG00000138741
• ENST00000379645
• ENSP00000368966

Symbol

• TRP3
• TRP3
• SCA41

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	0.92
molecular function	0.9
hub protein	0.82
metabolite	0.82
biological process	0.72

Protein Classes

PANTHER Classes

Protein / Transporter / Ion Channel / Short Transient Receptor Potential Channel 3

DTO Classes

Protein / Ion Channel / Transient Receptor Potential Calcium Channel (Trp-cc) Family / Strpc Subfamily / Trpc3 Sub-subfamily / Short Transient Receptor Potential Channel 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 425.68   (req: < 5)

Gene RIFs: 116   (req: <= 3)

Antibodies: 257   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 425.68   (req: >= 5)

Gene RIFs: 116   (req: > 3)

Antibodies: 257   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 35

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2