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Tdark tRNA wybutosine-synthesizing protein 2 homolog

S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to the C-7 position of 4-demethylwyosine (imG-14) to produce wybutosine-86.

Wybutosine (yW) is a hypermodified guanosine at the 3-prime position adjacent to the anticodon of phenylalanine tRNA that stabilizes codon-anticodon interactions during decoding on the ribosome. TRMT12 is the human homolog of a yeast gene essential for yW synthesis (Noma and Suzuki, 2006).[supplied by OMIM, Mar 2008]

 Comments

Property Summary

NCBI Gene PubMed Count 9
PubMed Score 4.79
PubTator Score 2.08

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (1)

Disease Target Count P-value
ovarian cancer 8520 7.5e-05
lung cancer 4740 3.1e-03
osteosarcoma 7950 3.2e-03
invasive ductal carcinoma 2951 1.0e-02

Expression

  Differential Expression (4)

Disease log2 FC p
invasive ductal carcinoma 1.300 1.0e-02
lung cancer 1.200 3.1e-03
osteosarcoma -1.219 3.2e-03
ovarian cancer 1.200 7.5e-05

Synonym

Accession Q53H54 Q6PKB9 Q96F21 Q9NWK6 tRNA-yW-synthesizing protein 2
Symbols TYW2
TRM12

Gene

TRMT12

PANTHER Protein Class (2)

  Ortholog (1)

Species Source Disease
Macaque OMA EggNOG Inparanoid

 UniProt Keyword (6)

 GO Function (1)

 GO Process (1)

 Compartment GO Term (2)

 GWAS Trait (2)

 HCA RNA Cell Line (55)

See all...

Pathway (5)

Protein-protein Interaction (3)

HSPA8   HSPA4   CCT2  

Gene RIF (1)

AA Sequence 

MRENVVVSNMERESGKPVAVVAVVTEPWFTQRYREYLQRQKLFDTQHRVEKMPDGSVALPVLGETLPEQH      1 - 70
LQELRNRVAPGSPCMLTQLPDPVPSKRAQGCSPAQKLCLEVSRWVEGRGVKWSAELEADLPRSWQRHGNL     71 - 140
LLLSEDCFQAKQWKNLGPELWETVALALGVQRLAKRGRVSPDGTRTPAVTLLLGDHGWVEHVDNGIRYKF    141 - 210
DVTQCMFSFGNITEKLRVASLSCAGEVLVDLYAGIGYFTLPFLVHAGAAFVHACEWNPHAVVALRNNLEI    211 - 280
NGVADRCQIHFGDNRKLKLSNIADRVILGLIPSSEEGWPIACQVLRQDAGGILHIHQNVESFPGKNLQAL    281 - 350
GVSKVEKEHWLYPQQITTNQWKNGATRDSRGKMLSPATKPEWQRWAESAETRIATLLQQVHGKPWKTQIL    351 - 420
HIQPVKSYAPHVDHIVLDLECCPCPSVG                                              421 - 448
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Text Mined References (10)

PMID Year Title