TRIT1
tRNA dimethylallyltransferase
Protein Summary
Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 of both cytosolic and mitochondrial tRNAs, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A). This gene encodes a protein that that is targeted to the mitochondrion and modifies transfer RNAs (tRNAs) by adding a dimethylallyl group onto the adenine at position 37. This modification is important for maintaining the correct reading frame during protein translation. This gene is considered a tumor suppressor and its expression can decrease cell growth. Alternative splicing results in multiple transcripts variants, most of which are likely non-functional. [provided by RefSeq, Aug 2015]
- ENST00000316891
- ENSP00000321810
- ENSG00000043514
- ENST00000372818
- ENSP00000361905
- ENST00000441669
- ENSP00000388333
- ENST00000537440
- ENSP00000437700
- IPT
- MOD5
- IPT
- GRO1
- IPPT
- MOD5
- hGRO1
- IPTase
- COXPD35
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 0.93 | ||
molecular function | 0.88 | ||
ligand (protein) perturbation | 0.83 | ||
kinase perturbation | 0.71 | ||
cell line | 0.67 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 466.23 (req: < 5)
Gene RIFs: 14 (req: <= 3)
Antibodies: 115 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 466.23 (req: >= 5)
Gene RIFs: 14 (req: > 3)
Antibodies: 115 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 6
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0