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Tbio E3 ubiquitin-protein ligase TRIM62

E3 ubiquitin ligase whose activity is dependent on E2 ubiquitin-conjugating enzyme UBE2D2.

 Comments

Property Summary

NCBI Gene PubMed Count 18
PubMed Score 7.51
PubTator Score 6.93

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (1)

Disease Target Count P-value
ovarian cancer 8520 1.4e-09
ependymoma 4679 2.3e-09
atypical teratoid/rhabdoid tumor 357 3.4e-07
psoriasis 6694 7.6e-04
osteosarcoma 7950 3.2e-03

Expression

  Differential Expression (5)

Disease log2 FC p
atypical teratoid/rhabdoid tumor -1.300 3.4e-07
ependymoma -1.100 2.3e-09
osteosarcoma -1.307 3.2e-03
ovarian cancer 1.100 1.4e-09
psoriasis 1.400 7.6e-04

Synonym

Accession Q9BVG3 B3KVH5 B4DTE4 D3DPR1 Q9NVG0
Symbols DEAR1

Gene

TRIM62

  Ortholog (1)

Species Source Disease
Macaque OMA EggNOG Inparanoid

 UniProt Keyword (11)

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 GO Function (2)

 GO Component (2)

 GO Process (9)

 Compartment GO Term (10)

 MGI Phenotype (5)

 HCA RNA Cell Line (56)

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Pathway (5)

Gene RIF (10)

AA Sequence 

MACSLKDELLCSICLSIYQDPVSLGCEHYFCRRCITEHWVRQEAQGARDCPECRRTFAEPALAPSLKLAN      1 - 70
IVERYSSFPLDAILNARRAARPCQAHDKVKLFCLTDRALLCFFCDEPALHEQHQVTGIDDAFDELQRELK     71 - 140
DQLQALQDSEREHTEALQLLKRQLAETKSSTKSLRTTIGEAFERLHRLLRERQKAMLEELEADTARTLTD    141 - 210
IEQKVQRYSQQLRKVQEGAQILQERLAETDRHTFLAGVASLSERLKGKIHETNLTYEDFPTSKYTGPLQY    211 - 280
TIWKSLFQDIHPVPAALTLDPGTAHQRLILSDDCTIVAYGNLHPQPLQDSPKRFDVEVSVLGSEAFSSGV    281 - 350
HYWEVVVAEKTQWVIGLAHEAASRKGSIQIQPSRGFYCIVMHDGNQYSACTEPWTRLNVRDKLDKVGVFL    351 - 420
DYDQGLLIFYNADDMSWLYTFREKFPGKLCSYFSPGQSHANGKNVQPLRINTVRI                   421 - 475
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Text Mined References (18)

PMID Year Title