| Tbio | E3 ubiquitin-protein ligase TRIM56 |
E3 ubiquitin-protein ligase that plays a key role in innate antiviral immunity (PubMed:21289118). In response to pathogen- and host-derived double-stranded DNA (dsDNA), targets TMEM173/STING to 'Lys-63'-linked ubiquitination, thereby promoting its homodimerization, a step required for the production of type I interferon IFN-beta (By similarity). Independently of its E3 ubiquitin ligase activity, positive regulator of TLR3 signaling. Potentiates extracellular double stranded RNA (dsRNA)-induced expression of IFNB1 and interferon-stimulated genes ISG15, IFIT1/ISG56, CXCL10, OASL and CCL5/RANTES. Promotes establishment of an antiviral state by TLR3 ligand and TLR3-mediated chemokine induction following infection by hepatitis C virus (PubMed:22948160).
Comments
| Disease | Target Count | P-value |
|---|---|---|
| juvenile dermatomyositis | 1187 | 2.6e-13 |
| astrocytoma | 1146 | 1.4e-11 |
| ependymoma | 4679 | 1.2e-08 |
| acute quadriplegic myopathy | 1158 | 6.1e-08 |
| hepatocellular carcinoma | 547 | 2.0e-06 |
| osteosarcoma | 7950 | 3.4e-05 |
| Astrocytoma, Pilocytic | 3081 | 3.7e-05 |
| invasive ductal carcinoma | 2951 | 2.0e-04 |
| cystic fibrosis | 1696 | 4.5e-04 |
| gastric cancer | 459 | 6.7e-04 |
| ovarian cancer | 8520 | 1.5e-03 |
| glioblastoma | 5792 | 3.3e-03 |
| group 4 medulloblastoma | 1855 | 4.4e-03 |
| medulloblastoma, large-cell | 6241 | 5.5e-03 |
| adult high grade glioma | 3801 | 1.8e-02 |
| subependymal giant cell astrocytoma | 2287 | 2.1e-02 |
| lung cancer | 4740 | 3.2e-02 |
| pancreatic ductal adenocarcinoma liver metastasis | 1962 | 4.5e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Endometritis | 21 | 3.023 | 1.5 |
| Disease | log2 FC | p |
|---|---|---|
| acute quadriplegic myopathy | 1.059 | 6.1e-08 |
| adult high grade glioma | 1.300 | 1.8e-02 |
| astrocytoma | 1.300 | 1.4e-11 |
| Astrocytoma, Pilocytic | 1.600 | 3.7e-05 |
| cystic fibrosis | -1.037 | 4.5e-04 |
| ependymoma | 1.200 | 1.2e-08 |
| gastric cancer | 1.300 | 6.7e-04 |
| glioblastoma | 1.400 | 3.3e-03 |
| group 4 medulloblastoma | -1.400 | 4.4e-03 |
| hepatocellular carcinoma | 1.200 | 2.0e-06 |
| invasive ductal carcinoma | -1.200 | 2.0e-04 |
| juvenile dermatomyositis | 1.237 | 2.6e-13 |
| lung cancer | -1.400 | 3.2e-02 |
| medulloblastoma, large-cell | -1.300 | 5.5e-03 |
| osteosarcoma | -2.460 | 3.4e-05 |
| ovarian cancer | -1.100 | 1.5e-03 |
| pancreatic ductal adenocarcinoma liver m... | 1.098 | 4.5e-02 |
| subependymal giant cell astrocytoma | 1.778 | 2.1e-02 |
MVSHGSSPSLLEALSSDFLACKICLEQLRAPKTLPCLHTYCQDCLAQLADGGRVRCPECRETVPVPPEGV 1 - 70 ASFKTNFFVNGLLDLVKARACGDLRAGKPACALCPLVGGTSTGGPATARCLDCADDLCQACADGHRCTRQ 71 - 140 THTHRVVDLVGYRAGWYDEEARERQAAQCPQHPGEALRFLCQPCSQLLCRECRLDPHLDHPCLPLAEAVR 141 - 210 ARRPGLEGLLAGVDNNLVELEAARRVEKEALARLREQAARVGTQVEEAAEGVLRALLAQKQEVLGQLRAH 211 - 280 VEAAEEAARERLAELEGREQVARAAAAFARRVLSLGREAEILSLEGAIAQRLRQLQGCPWAPGPAPCLLP 281 - 350 QLELHPGLLDKNCHLLRLSFEEQQPQKDGGKDGAGTQGGEESQSRREDEPKTERQGGVQPQAGDGAQTPK 351 - 420 EEKAQTTREEGAQTLEEDRAQTPHEDGGPQPHRGGRPNKKKKFKGRLKSISREPSPALGPNLDGSGLLPR 421 - 490 PIFYCSFPTRMPGDKRSPRITGLCPFGPREILVADEQNRALKRFSLNGDYKGTVPVPEGCSPCSVAALQS 491 - 560 AVAFSASARLYLINPNGEVQWRRALSLSQASHAVAALPSGDRVAVSVAGHVEVYNMEGSLATRFIPGGKA 561 - 630 SRGLRALVFLTTSPQGHFVGSDWQQNSVVICDGLGQVVGEYKGPGLHGCQPGSVSVDKKGYIFLTLREVN 631 - 700 KVVILDPKGSLLGDFLTAYHGLEKPRVTTMVDGRYLVVSLSNGTIHIFRVRSPDS 701 - 755 //
