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Tbio
TRIM55
Tripartite motif-containing protein 55

Protein Summary
Description
May regulate gene expression and protein turnover in muscle cells. The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. This protein associates transiently with microtubules, myosin, and titin during muscle sarcomere assembly. It may act as a transient adaptor and plays a regulatory role in the assembly of sarcomeres. Four alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000276573
  • ENSP00000276573
  • ENSG00000147573
  • ENST00000315962
  • ENSP00000323913
  • ENST00000350034
  • ENSP00000332302
  • ENST00000353317
  • ENSP00000297348

Symbol
  • MURF2
  • RNF29
  • RNF29
  • muRF2
  • MURF-2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
microRNA
0.6
cell line
0.57
transcription factor
0.55
kinase perturbation
0.54


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.11   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 167   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.11   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 167   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0