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Tchem
TRIM24
Transcription intermediary factor 1-alpha

Protein Summary
Description
Transcriptional coactivator that interacts with numerous nuclear receptors and coactivators and modulates the transcription of target genes. Interacts with chromatin depending on histone H3 modifications, having the highest affinity for histone H3 that is both unmodified at 'Lys-4' (H3K4me0) and acetylated at 'Lys-23' (H3K23ac). Has E3 protein-ubiquitin ligase activity. Promotes ubiquitination and proteasomal degradation of p53/TP53. Plays a role in the regulation of cell proliferation and apoptosis, at least in part via its effects on p53/TP53 levels. Up-regulates ligand-dependent transcription activation by AR, GCR/NR3C1, thyroid hormone receptor (TR) and ESR1. Modulates transcription activation by retinoic acid (RA) receptors, including RARA. Plays a role in regulating retinoic acid-dependent proliferation of hepatocytes (By similarity). The protein encoded by this gene mediates transcriptional control by interaction with the activation function 2 (AF2) region of several nuclear rec ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000343526
  • ENSP00000340507
  • ENSG00000122779
  • ENST00000415680
  • ENSP00000390829

Symbol
  • RNF82
  • TIF1
  • TIF1A
  • PTC6
  • TF1A
  • TIF1
  • RNF82
  • TIF1A
  • hTIF1
  • TIF1ALPHA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
molecular function
0.99
transcription factor perturbation
0.98
co-expressed gene
0.97
hub protein
0.97


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 228.69   (req: < 5)
Gene RIFs: 58   (req: <= 3)
Antibodies: 468   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 228.69   (req: >= 5)
Gene RIFs: 58   (req: > 3)
Antibodies: 468   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 44
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0