| Tclin | Thyrotropin-releasing hormone receptor |
Receptor for thyrotropin-releasing hormone. This receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.
This gene encodes a G protein-coupled receptor for thyrotropin-releasing hormone (TRH). Upon binding to TRH, this receptor activates the inositol phospholipid-calcium-protein kinase C transduction pathway. Mutations in this gene have been associated with generalized thyrotropin-releasing hormone resistance. [provided by RefSeq, Sep 2011]
This gene encodes a G protein-coupled receptor for thyrotropin-releasing hormone (TRH). Upon binding to TRH, this receptor activates the inositol phospholipid-calcium-protein kinase C transduction pathway. Mutations in this gene have been associated with generalized thyrotropin-releasing hormone resistance. [provided by RefSeq, Sep 2011]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Hypothyroidism | 122 | 4.41 | 2.2 |
| Thyroid Hormone Resistance Syndrome | 5 | 0.0 | 0.0 |
| Disease | Target Count |
|---|---|
| Diagnostic Test for Thyroid Dysfunction | 3 |
| Pituitary Function Studies | 1 |
| Spinocerebellar disease | 1 |
| Disease | Target Count | P-value |
|---|---|---|
| medulloblastoma, large-cell | 6241 | 4.8e-04 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Osteoporosis | 363 | 0.0 | 3.0 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Congenital hypothyroidism | 26 | 0.0 | 5.0 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Adrenocorticotropic hormone deficiency | 1 | 3.531 | 1.8 |
| Disease | Target Count |
|---|---|
| Resistance to thyrotropin-releasing hormone syndrome | 1 |
| Species | Source | Disease |
|---|---|---|
| Inparanoid OMA | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| OMA EggNOG | ||
| Inparanoid EggNOG | ||
| Inparanoid OMA | ||
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG |
taltirelin
pKi 6.50
protirelin
pKi 7.70
chlordiazepoxide
pKi 4.82
diazepam
pKi 5.15
midazolam
pKi 5.49
MENETVSELNQTQLQPRAVVALEYQVVTILLVLIICGLGIVGNIMVVLVVMRTKHMRTPTNCYLVSLAVA 1 - 70 DLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIKAQFLCTFS 71 - 140 RAKKIIIFVWAFTSLYCMLWFFLLDLNISTYKDAIVISCGYKISRNYYSPIYLMDFGVFYVVPMILATVL 141 - 210 YGFIARILFLNPIPSDPKENSKTWKNDSTHQNTNLNVNTSNRCFNSTVSSRKQVTKMLAVVVILFALLWM 211 - 280 PYRTLVVVNSFLSSPFQENWFLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKPANYSV 281 - 350 ALNYSVIKESDHFSTELDDITVTDTYLSATKVSFDDTCLASEVSFSQS 351 - 398 //
