Tclin | Thyrotropin-releasing hormone receptor |
This gene encodes a G protein-coupled receptor for thyrotropin-releasing hormone (TRH). Upon binding to TRH, this receptor activates the inositol phospholipid-calcium-protein kinase C transduction pathway. Mutations in this gene have been associated with generalized thyrotropin-releasing hormone resistance. [provided by RefSeq, Sep 2011]
Comments
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Hypothyroidism | 122 | 4.41 | 2.2 |
Thyroid Hormone Resistance Syndrome | 5 | 0.0 | 0.0 |
Disease | Target Count |
---|---|
Diagnostic Test for Thyroid Dysfunction | 3 |
Pituitary Function Studies | 1 |
Spinocerebellar disease | 1 |
Disease | Target Count | P-value |
---|---|---|
medulloblastoma, large-cell | 6241 | 4.8e-04 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Osteoporosis | 363 | 0.0 | 3.0 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Congenital hypothyroidism | 26 | 0.0 | 5.0 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Adrenocorticotropic hormone deficiency | 1 | 3.531 | 1.8 |
Disease | Target Count |
---|---|
Resistance to thyrotropin-releasing hormone syndrome | 1 |
Species | Source | Disease |
---|---|---|
Inparanoid OMA | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
OMA EggNOG | ||
Inparanoid EggNOG | ||
Inparanoid OMA | ||
OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG |
CHEMBL224730
pKi 8.52
taltirelin
- 6.50
MeTRH
- 8.50
[3H]MeTRH
- 8.50
chlordiazepoxide
pKi 4.82
diazepam
pKi 5.15
midazolam
pKi 5.49
MENETVSELNQTQLQPRAVVALEYQVVTILLVLIICGLGIVGNIMVVLVVMRTKHMRTPTNCYLVSLAVA 1 - 70 DLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIKAQFLCTFS 71 - 140 RAKKIIIFVWAFTSLYCMLWFFLLDLNISTYKDAIVISCGYKISRNYYSPIYLMDFGVFYVVPMILATVL 141 - 210 YGFIARILFLNPIPSDPKENSKTWKNDSTHQNTNLNVNTSNRCFNSTVSSRKQVTKMLAVVVILFALLWM 211 - 280 PYRTLVVVNSFLSSPFQENWFLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKPANYSV 281 - 350 ALNYSVIKESDHFSTELDDITVTDTYLSATKVSFDDTCLASEVSFSQS 351 - 398 //