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Tclin Thyrotropin-releasing hormone receptor

Receptor for thyrotropin-releasing hormone. This receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system.

This gene encodes a G protein-coupled receptor for thyrotropin-releasing hormone (TRH). Upon binding to TRH, this receptor activates the inositol phospholipid-calcium-protein kinase C transduction pathway. Mutations in this gene have been associated with generalized thyrotropin-releasing hormone resistance. [provided by RefSeq, Sep 2011]

 Comments

Property Summary

Ligand Count 9
NCBI Gene PubMed Count 30
PubMed Score 73.00
PubTator Score 82.78

Knowledge Summary

Patent (4,964)

TINX Plot

  Disease (9)

Disease Target Count Z-score Confidence
Hypothyroidism 122 4.41 2.2
Thyroid Hormone Resistance Syndrome 5 0.0 0.0
Disease Target Count P-value
medulloblastoma, large-cell 6241 4.8e-04
Disease Target Count Z-score Confidence
Carcinoma 11493 0.0 0.9
Disease Target Count Z-score Confidence
Osteoporosis 363 0.0 3.0
Disease Target Count Z-score Confidence
Congenital hypothyroidism 26 0.0 5.0
Disease Target Count Z-score Confidence
Adrenocorticotropic hormone deficiency 1 3.531 1.8

Expression

  Differential Expression (1)

Disease log2 FC p
medulloblastoma, large-cell 1.300 4.8e-04

Synonym

Accession P34981 Q2M339 TRH-R
Symbols TRH-R

Gene

TRHR

  Ortholog (14)

Species Source Disease
Inparanoid OMA
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
OMA EggNOG
Inparanoid EggNOG
Inparanoid OMA
OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG

 UniProt Keyword (12)

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 GO Function (1)

 GO Component (2)

 GO Process (1)

 Compartment GO Term (12)

 OMIM Phenotype (1)

 MGI Phenotype (4)

 GWAS Trait (5)

 HCA RNA Cell Line (22)

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 CSPA Cell Line (4)

Pathway (12)

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Protein-protein Interaction (1)

ACP2  

Drug (2)

Structure of taltirelin

taltirelin
pKi 6.50

Structure of protirelin

protirelin
pKi 7.70

Ligand (7)

Structure of CHEMBL224730

CHEMBL224730
pKi 8.52

Structure of taltirelin

taltirelin
- 6.50

Structure of MeTRH

MeTRH
- 8.50

Structure of IUPHAR2141

[3H]MeTRH
- 8.50

Structure of chlordiazepoxide

chlordiazepoxide
pKi 4.82

Structure of diazepam

diazepam
pKi 5.15

Structure of midazolam

midazolam
pKi 5.49

Gene RIF (14)

AA Sequence 

MENETVSELNQTQLQPRAVVALEYQVVTILLVLIICGLGIVGNIMVVLVVMRTKHMRTPTNCYLVSLAVA      1 - 70
DLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFTIERYIAICHPIKAQFLCTFS     71 - 140
RAKKIIIFVWAFTSLYCMLWFFLLDLNISTYKDAIVISCGYKISRNYYSPIYLMDFGVFYVVPMILATVL    141 - 210
YGFIARILFLNPIPSDPKENSKTWKNDSTHQNTNLNVNTSNRCFNSTVSSRKQVTKMLAVVVILFALLWM    211 - 280
PYRTLVVVNSFLSSPFQENWFLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKPANYSV    281 - 350
ALNYSVIKESDHFSTELDDITVTDTYLSATKVSFDDTCLASEVSFSQS                          351 - 398
//

Text Mined References (30)

PMID Year Title