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Tbio
TREML1
Trem-like transcript 1 protein

Protein Summary
Description
Cell surface receptor that may play a role in the innate and adaptive immune response. This gene encodes a member of the triggering receptor expressed on myeloid cells-like (TREM) family. The encoded protein is a type 1 single Ig domain orphan receptor localized to the alpha-granule membranes of platelets. The encoded protein is involved in platelet aggregation, inflammation, and cellular activation and has been linked to Gray platelet syndrome. Alternative splicing results in multiple transcript variants [provided by RefSeq, Nov 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373127
  • ENSP00000362219
  • ENSG00000161911
  • ENST00000426005
  • ENSP00000402855
  • ENST00000437044
  • ENSP00000400405

Symbol
  • TLT1
  • TLT1
  • TLT-1
  • PRO3438
  • GLTL1825
  • dJ238O23.3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cellular component
0.57
tissue sample
0.56
cell line
0.51
cell type or tissue
0.46
protein domain
0.41


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.36   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 268   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 38.36   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 268   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0