Tchem TREH Trehalase

Protein Summary

Description

Intestinal trehalase is probably involved in the hydrolysis of ingested trehalose. This gene encodes an enzyme that hydrolyses trehalose, a disaccharide formed from two glucose molecules found mainly in fungi, plants, and insects. A partial duplication of this gene is located adjacent to this locus on chromosome 11. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

Uniprot Accession IDs

• O43280
• Q32MB9
• Q53FY8

Gene Name

• TREH

Ensembl ID

• ENST00000264029
• ENSP00000264029
• ENSG00000118094
• ENST00000397925
• ENSP00000381020

Symbol

• TREA
• TRE
• TREA
• TREHD

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	0.76
cell type or tissue	0.65
cellular component	0.6
gene perturbation	0.57
disease perturbation	0.56

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 259.98   (req: < 5)

Gene RIFs: 7   (req: <= 3)

Antibodies: 101   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 259.98   (req: >= 5)

Gene RIFs: 7   (req: > 3)

Antibodies: 101   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0