| Tbio | Trafficking protein particle complex subunit 4 |
May play a role in vesicular transport from endoplasmic reticulum to Golgi.
Comments
| Disease | Target Count | P-value |
|---|---|---|
| lung carcinoma | 2844 | 3.5e-17 |
| osteosarcoma | 7933 | 3.1e-08 |
| ovarian cancer | 8491 | 2.2e-05 |
| medulloblastoma, large-cell | 6234 | 3.9e-05 |
| Multiple myeloma | 1327 | 3.1e-03 |
| Waldenstrons macroglobulinemia | 764 | 5.4e-03 |
| Disease | log2 FC | p |
|---|---|---|
| Waldenstrons macroglobulinemia | 1.351 | 5.4e-03 |
| Multiple myeloma | 1.097 | 3.1e-03 |
| osteosarcoma | -2.723 | 3.1e-08 |
| medulloblastoma, large-cell | 1.100 | 3.9e-05 |
| lung carcinoma | 1.200 | 3.5e-17 |
| ovarian cancer | 2.200 | 2.2e-05 |
| PMID | Text | |
|---|---|---|
| 24104608 | Synbindin contributes to malignant phenotypes of GC by activating ERK on the Golgi, and synbindin is a potential biomarker and therapeutic target for GC. | |
| 23625650 | Overexpression of TRAPPC4 increased colorectal carcinogenesis. | |
| 21826244 | Data demonstrate that TRAPPC4 may regulate cell proliferation and apoptosis in CRC by interaction with ERK2 and phosphorylating ERK1/2 as well as modulating the subcellular location of pERK1/2 to activate the relevant signaling pathway. | |
| 20035503 | Observational study of gene-disease association. (HuGE Navigator) | |
| 18466758 | The three-dimensional structure of human synbindin, which contains a longin domain and an atypical PDZ domain is presented. |
| PMID | Year | Title | |
|---|---|---|---|
| 24104608 | 2013 | Synbindin in extracellular signal-regulated protein kinase spatial regulation and gastric cancer aggressiveness. | |
| 23625650 | 2014 | The role of ERK2 in colorectal carcinogenesis is partly regulated by TRAPPC4. | |
| 21826244 | 2011 | TRAPPC4-ERK2 interaction activates ERK1/2, modulates its nuclear localization and regulates proliferation and apoptosis of colorectal cancer cells. | |
| 21525244 | 2011 | C4orf41 and TTC-15 are mammalian TRAPP components with a role at an early stage in ER-to-Golgi trafficking. | |
| 21269460 | 2011 | Initial characterization of the human central proteome. | |
| 20035503 | 2009 | Single-cell expression profiling of dopaminergic neurons combined with association analysis identifies pyridoxal kinase as Parkinson's disease gene. | |
| 19416478 | 2009 | TRAPPC2L is a novel, highly conserved TRAPP-interacting protein. | |
| 18466758 | 2009 | Crystal structure of human synbindin reveals two conformations of longin domain. | |
| 17110339 | 2006 | The architecture of the multisubunit TRAPP I complex suggests a model for vesicle tethering. | |
| 16554811 | 2006 | Human chromosome 11 DNA sequence and analysis including novel gene identification. | |
| 15489334 | 2004 | The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). | |
| 15342556 | 2004 | Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. | |
| 14702039 | 2004 | Complete sequencing and characterization of 21,243 full-length human cDNAs. | |
| 12477932 | 2002 | Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. | |
| 11805826 | 2002 | Functional organization of the yeast proteome by systematic analysis of protein complexes. | |
| 11042152 | 2000 | Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells. | |
| 11018053 | 2000 | Synbindin, A novel syndecan-2-binding protein in neuronal dendritic spines. | |
| 10810093 | 2000 | Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. | |
| 8125298 | 1994 | Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |
