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  5. Heat shock protein 75 kDa, mitochondrial

Tchem Heat shock protein 75 kDa, mitochondrial

Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, downstream of PINK1 and mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA.

This gene encodes a mitochondrial chaperone protein that is member of the heat shock protein 90 (HSP90) family. The encoded protein has ATPase activity and interacts with tumor necrosis factor type I. This protein may function in regulating cellular stress responses. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]

 Comments

Property Summary

Ligand Count 12
NCBI Gene PubMed Count 80
PubMed Score 16.24
PubTator Score 84.89

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (5)

Disease Target Count Z-score Confidence
Disease Progression 136 0.0 0.0
Osteoarthritis 184 0.0 0.0
Stomach Neoplasms 300 0.0 0.0
Disease Target Count
Degenerative polyarthritis 115
Disease Target Count P-value
non-small cell lung cancer 2890 1.7e-18
ovarian cancer 8520 7.5e-05
lung cancer 4740 2.6e-03
medulloblastoma, large-cell 6241 6.1e-03
Disease Target Count Z-score Confidence
Carcinoma 11493 0.0 0.7
Disease Target Count Z-score Confidence
VACTERL association 26 3.303 1.7

Expression

  Differential Expression (4)

Disease log2 FC p
lung cancer 1.300 2.6e-03
medulloblastoma, large-cell 1.100 6.1e-03
non-small cell lung cancer 1.138 1.7e-18
ovarian cancer 1.100 7.5e-05

Synonym

Accession Q12931 B4DR68 D3DUC8 F5H897 O43642 O75235 Q9UHL5 HSP 75
Symbols HSP75
HSP 75
HSP90L
TRAP-1

Gene

TRAP1

PANTHER Protein Class (2)

  Ortholog (14)

Species Source Disease
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
OMA EggNOG
Inparanoid EggNOG
OMA EggNOG
Inparanoid OMA
OMA EggNOG
Inparanoid OMA EggNOG

 UniProt Keyword (14)

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 GO Function (5)

 GO Component (8)

 GO Process (6)

 Compartment GO Term (34)

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 MGI Phenotype (8)

 GWAS Trait (7)

 HCA RNA Cell Line (56)

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Pathway (8)

Protein-protein Interaction (3)

DYNC1H1   ARSF   FNBP4  

PDB (9)

Ligand (12)

Structure of CHEMBL560895

CHEMBL560895
pKi 6.10

Structure of CHEMBL278315

CHEMBL278315
pIC50 6.18

Structure of CHEMBL252164

CHEMBL252164
pIC50 6.27

Structure of CHEMBL3104859

CHEMBL3104859
pKi 6.49

Structure of CHEMBL1230584

CHEMBL1230584
pKi 6.59

Structure of CHEMBL200102

CHEMBL200102
pIC50 6.69

Structure of CHEMBL467399

CHEMBL467399
pIC50 7.05

Structure of CHEMBL2103879

CHEMBL2103879
pIC50 7.29

Structure of CHEMBL2419341

CHEMBL2419341
pKd 7.29

Structure of CHEMBL2419342

CHEMBL2419342
pKd 8.23

Structure of CHEMBL1910764

CHEMBL1910764
pKd 8.24

Structure of luminespib

luminespib
pIC50 7.80

Gene RIF (61)

AA Sequence 

MARELRALLLWGRRLRPLLRAPALAAVPGGKPILCPRRTTAQLGPRRNPAWSLQAGRLFSTQTAEDKEEP      1 - 70
LHSIISSTESVQGSTSKHEFQAETKKLLDIVARSLYSEKEVFIRELISNASDALEKLRHKLVSDGQALPE     71 - 140
MEIHLQTNAEKGTITIQDTGIGMTQEELVSNLGTIARSGSKAFLDALQNQAEASSKIIGQFGVGFYSAFM    141 - 210
VADRVEVYSRSAAPGSLGYQWLSDGSGVFEIAEASGVRTGTKIIIHLKSDCKEFSSEARVRDVVTKYSNF    211 - 280
VSFPLYLNGRRMNTLQAIWMMDPKDVREWQHEEFYRYVAQAHDKPRYTLHYKTDAPLNIRSIFYVPDMKP    281 - 350
SMFDVSRELGSSVALYSRKVLIQTKATDILPKWLRFIRGVVDSEDIPLNLSRELLQESALIRKLRDVLQQ    351 - 420
RLIKFFIDQSKKDAEKYAKFFEDYGLFMREGIVTATEQEVKEDIAKLLRYESSALPSGQLTSLSEYASRM    421 - 490
RAGTRNIYYLCAPNRHLAEHSPYYEAMKKKDTEVLFCFEQFDELTLLHLREFDKKKLISVETDIVVDHYK    491 - 560
EEKFEDRSPAAECLSEKETEELMAWMRNVLGSRVTNVKVTLRLDTHPAMVTVLEMGAARHFLRMQQLAKT    561 - 630
QEERAQLLQPTLEINPRHALIKKLNQLRASEPGLAQLLVDQIYENAMIAAGLVDDPRAMVGRLNELLVKA    631 - 700
LERH                                                                      701 - 704
//

Text Mined References (87)

PMID Year Title