Tchem | Heat shock protein 75 kDa, mitochondrial |
This gene encodes a mitochondrial chaperone protein that is member of the heat shock protein 90 (HSP90) family. The encoded protein has ATPase activity and interacts with tumor necrosis factor type I. This protein may function in regulating cellular stress responses. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]
Comments
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Disease Progression | 136 | 0.0 | 0.0 |
Osteoarthritis | 184 | 0.0 | 0.0 |
Stomach Neoplasms | 300 | 0.0 | 0.0 |
Disease | Target Count |
---|---|
Degenerative polyarthritis | 115 |
Disease | Target Count | P-value |
---|---|---|
non-small cell lung cancer | 2890 | 1.7e-18 |
ovarian cancer | 8520 | 7.5e-05 |
lung cancer | 4740 | 2.6e-03 |
medulloblastoma, large-cell | 6241 | 6.1e-03 |
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
VACTERL association | 26 | 3.303 | 1.7 |
Disease | log2 FC | p |
---|---|---|
lung cancer | 1.300 | 2.6e-03 |
medulloblastoma, large-cell | 1.100 | 6.1e-03 |
non-small cell lung cancer | 1.138 | 1.7e-18 |
ovarian cancer | 1.100 | 7.5e-05 |
Species | Source | Disease |
---|---|---|
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
Inparanoid OMA EggNOG | ||
OMA EggNOG | ||
Inparanoid EggNOG | ||
OMA EggNOG | ||
Inparanoid OMA | ||
OMA EggNOG | ||
Inparanoid OMA EggNOG |
CHEMBL560895
pKi 6.10
CHEMBL278315
pIC50 6.18
CHEMBL252164
pIC50 6.27
CHEMBL3104859
pKi 6.49
CHEMBL1230584
pKi 6.59
CHEMBL200102
pIC50 6.69
CHEMBL467399
pIC50 7.05
CHEMBL2103879
pIC50 7.29
CHEMBL2419341
pKd 7.29
CHEMBL2419342
pKd 8.23
CHEMBL1910764
pKd 8.24
luminespib
pIC50 7.80
MARELRALLLWGRRLRPLLRAPALAAVPGGKPILCPRRTTAQLGPRRNPAWSLQAGRLFSTQTAEDKEEP 1 - 70 LHSIISSTESVQGSTSKHEFQAETKKLLDIVARSLYSEKEVFIRELISNASDALEKLRHKLVSDGQALPE 71 - 140 MEIHLQTNAEKGTITIQDTGIGMTQEELVSNLGTIARSGSKAFLDALQNQAEASSKIIGQFGVGFYSAFM 141 - 210 VADRVEVYSRSAAPGSLGYQWLSDGSGVFEIAEASGVRTGTKIIIHLKSDCKEFSSEARVRDVVTKYSNF 211 - 280 VSFPLYLNGRRMNTLQAIWMMDPKDVREWQHEEFYRYVAQAHDKPRYTLHYKTDAPLNIRSIFYVPDMKP 281 - 350 SMFDVSRELGSSVALYSRKVLIQTKATDILPKWLRFIRGVVDSEDIPLNLSRELLQESALIRKLRDVLQQ 351 - 420 RLIKFFIDQSKKDAEKYAKFFEDYGLFMREGIVTATEQEVKEDIAKLLRYESSALPSGQLTSLSEYASRM 421 - 490 RAGTRNIYYLCAPNRHLAEHSPYYEAMKKKDTEVLFCFEQFDELTLLHLREFDKKKLISVETDIVVDHYK 491 - 560 EEKFEDRSPAAECLSEKETEELMAWMRNVLGSRVTNVKVTLRLDTHPAMVTVLEMGAARHFLRMQQLAKT 561 - 630 QEERAQLLQPTLEINPRHALIKKLNQLRASEPGLAQLLVDQIYENAMIAAGLVDDPRAMVGRLNELLVKA 631 - 700 LERH 701 - 704 //