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Tbio
TRAF3IP2
Adapter protein CIKS

Protein Summary
Description
Could be involved in the activation of both NF-kappa-B via a NF-kappa-B inhibitor kinase (IKK)-dependent mechanism and stress-activated protein kinase (SAPK)/JNK. This gene encodes a protein involved in regulating responses to cytokines by members of the Rel/NF-kappaB transcription factor family. These factors play a central role in innate immunity in response to pathogens, inflammatory signals and stress. This gene product interacts with TRAF proteins (tumor necrosis factor receptor-associated factors) and either I-kappaB kinase or MAP kinase to activate either NF-kappaB or Jun kinase. Several alternative transcripts encoding different isoforms have been identified. Another transcript, which does not encode a protein and is transcribed in the opposite orientation, has been identified. Overexpression of this transcript has been shown to reduce expression of at least one of the protein encoding transcripts, suggesting it has a regulatory role in the expression of this gene. [provided by ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000340026
  • ENSP00000345984
  • ENSG00000056972
  • ENST00000359831
  • ENSP00000352889
  • ENST00000368735
  • ENSP00000357724
  • ENST00000368761
  • ENSP00000357750
  • ENST00000392556
  • ENSP00000376339

Symbol
  • C6orf2
  • C6orf4
  • C6orf5
  • C6orf6
  • ACT1
  • CIKS
  • C6orf2
  • C6orf4
  • C6orf5
  • C6orf6
  • CANDF8
  • PSORS13
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
0.97
kinase perturbation
0.91
gene perturbation
0.83
virus perturbation
0.83
trait
0.75


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.66   (req: < 5)
Gene RIFs: 52   (req: <= 3)
Antibodies: 403   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.66   (req: >= 5)
Gene RIFs: 52   (req: > 3)
Antibodies: 403   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0