Tbio TRABD2B Metalloprotease TIKI2

Protein Summary

Description

Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the 8 N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oligomers, leading to their inactivation. Able to cleave WNT3A, WNT5, but not WNT11. Required for head formation.

Uniprot Accession IDs

• A6NFA1
• I6U4Y0

Gene Name

• TRABD2B

Ensembl ID

• ENST00000606738
• ENSP00000476820
• ENSG00000269113

Symbol

• HKAT
• TIKI2
• TIKI2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cellular component	0.76
microRNA	0.71
tissue	0.66
cell type or tissue	0.63
tissue sample	0.6

Protein Classes

PANTHER Classes

Protein / ... / Metalloprotease / Metalloprotease Tiki2

DTO Classes

Protein / Enzyme / Protease / Metalloprotease / Metalloprotease Tiki2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 6   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 6   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0