TP53RK
EKC/KEOPS complex subunit TP53RK
Protein Summary
Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine (PubMed:22912744, PubMed:27903914). The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37 (PubMed:22912744, PubMed:27903914). TP53RK has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit OSGEP (By similarity). Atypical protein kinase that phosphorylates 'Ser-15' of p53/TP53 protein and may therefore participate in its activation (PubMed:11546806).
- ENST00000372114
- ENSP00000361186
- ENSG00000172315
- C20orf64
- PRPK
- PRPK
- BUD32
- GAMOS4
- Nori-2
- Nori-2p
- dJ101A2
- C20orf64
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.94 | ||
transcription factor binding site profile | 0.79 | ||
protein domain | 0.73 | ||
transcription factor | 0.64 | ||
hub protein | 0.63 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 36.72 (req: < 5)
Gene RIFs: 9 (req: <= 3)
Antibodies: 257 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 36.72 (req: >= 5)
Gene RIFs: 9 (req: > 3)
Antibodies: 257 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 8
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0