Tdark TOGARAM1 TOG array regulator of axonemal microtubules protein 1

Protein Summary

Description

Required for normal structure and function of primary cilia. Plays a role in the organization of axoneme microtubule bundles in primary cilia (By similarity). Interacts with microtubules and promotes microtubule polymerization via its HEAT repeat domains, especially those in TOG region 2 and 4 (By similarity).

Uniprot Accession IDs

• Q9Y4F4
• Q68D66
• Q6PG27

Gene Name

• TOGARAM1

Ensembl ID

• ENST00000361577
• ENSP00000355045
• ENSG00000198718
• ENST00000557423
• ENSP00000451829

Symbol

• FAM179B
• KIAA0423
• FAM179B
• KIAA0423

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0
biological term	0
cell line	0
cell type or tissue	0
cellular component	0

Protein Classes

PANTHER Classes

Protein / Structural Protein / Tog Array Regulator Of Axonemal Microtubules Protein 1

DTO Classes

Protein / Cellular Structure / Tog Array Regulator Of Axonemal Microtubules Protein 1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.47   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 11   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4.47   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 11   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0