| Tchem | Serine/threonine-protein kinase TNNI3K |
This gene encodes a protein that belongs to the MAP kinase kinase kinase (MAPKKK) family of protein kinases. The protein contains ankyrin repeat, protein kinase and serine-rich domains and is thought to play a role in cardiac physiology. [provided by RefSeq, Sep 2012]
Comments
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| CARDIAC CONDUCTION DISEASE WITH OR WITHOUT DILATED CARDIOMYOPATHY | 1 | 0.0 | 0.0 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Acquired metabolic disease | 336 | 0.0 | 3.0 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Cardiomyopathy | 116 | 3.258 | 1.6 |
| Disease | Target Count |
|---|---|
| Familial atrial tachyarrhythmia-infra-Hisian cardiac conduction disease | 1 |
CHEMBL3815093
pIC50 7.60
CHEMBL3814923
pIC50 7.60
CHEMBL3814871
pIC50 7.60
CHEMBL3815116
pIC50 7.60
CHEMBL3814635
pIC50 7.60
CHEMBL3814442
pIC50 7.60
CHEMBL3613184
pIC50 7.60
CHEMBL3613193
pIC50 7.70
CHEMBL3613190
pIC50 7.70
CHEMBL3613307
pIC50 7.80
CHEMBL3814010
pIC50 7.80
CHEMBL3613309
pIC50 7.80
CHEMBL3814998
pIC50 7.89
CHEMBL3613199
pIC50 7.89
CHEMBL3813948
pIC50 7.89
CHEMBL3813957
pIC50 7.89
CHEMBL3613187
pIC50 7.89
CHEMBL3613189
pIC50 7.89
CHEMBL3613186
pIC50 7.89
CHEMBL3613185
pIC50 7.89
MGNYKSRPTQTCTDEWKKKVSESYVITIERLEDDLQIKEKELTELRNIFGSDEAFSKVNLNYRTENGLSL 1 - 70 LHLCCICGGKKSHIRTLMLKGLRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTALHI 71 - 140 ATIAGHLEAADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVSGEVGDRPLHLASAK 141 - 210 GFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSDLEVQPHVVNIYGDTPLHLACYN 211 - 280 GKFEVAKEIIQISGTESLTKENIFSETAFHSACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHSACYH 281 - 350 GHIRLVQFLLDNGADMNLVACDPSRSSGEKDEQTCLMWAYEKGHDAIVTLLKHYKRPQDELPCNEYSQPG 351 - 420 GDGSYVSVPSPLGKIKSMTKEKADILLLRAGLPSHFHLQLSEIEFHEIIGSGSFGKVYKGRCRNKIVAIK 421 - 490 RYRANTYCSKSDVDMFCREVSILCQLNHPCVIQFVGACLNDPSQFAIVTQYISGGSLFSLLHEQKRILDL 491 - 560 QSKLIIAVDVAKGMEYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFGESRFLQSLDEDNMTKQPGNLRW 561 - 630 MAPEVFTQCTRYTIKADVFSYALCLWEILTGEIPFAHLKPAAAAADMAYHHIRPPIGYSIPKPISSLLIR 631 - 700 GWNACPEGRPEFSEVVMKLEECLCNIELMSPASSNSSGSLSPSSSSDCLVNRGGPGRSHVAALRSRFELE 701 - 770 YALNARSYAALSQSAGQYSSQGLSLEEMKRSLQYTPIDKYGYVSDPMSSMHFHSCRNSSSFEDSS 771 - 835 //
