Property Summary

NCBI Gene PubMed Count 14
PubMed Score 6.42
PubTator Score 9.08

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (8)

Disease log2 FC p
astrocytic glioma -1.200 6.4e-03
ependymoma -1.200 6.7e-03
oligodendroglioma -1.300 3.1e-03
atypical teratoid / rhabdoid tumor -1.100 2.4e-06
glioblastoma -1.100 9.1e-06
primitive neuroectodermal tumor -1.100 2.3e-04
diabetes mellitus -1.500 3.6e-02
psoriasis -1.300 7.1e-35

Protein-protein Interaction (12)

Gene RIF (4)

PMID Text
20628086 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19913121 Observational study of gene-disease association. (HuGE Navigator)
19460752 Knockdown of troponin C type 2 (TNNC2) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells
1907279 HIV-1 protease hydrolyzes troponin C at amino acid residues 101-102

AA Sequence

MTDQQAEARSYLSEEMIAEFKAAFDMFDADGGGDISVKELGTVMRMLGQTPTKEELDAIIEEVDEDGSGT      1 - 70
IDFEEFLVMMVRQMKEDAKGKSEEELAECFRIFDRNADGYIDPEELAEIFRASGEHVTDEEIESLMKDGD     71 - 140
KNNDGRIDFDEFLKMMEGVQ                                                      141 - 160
//

Text Mined References (15)

PMID Year Title
25416956 2014 A proteome-scale map of the human interactome network.
20628086 2010 Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
19913121 2009 Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
17194691 2007 Mutations in fast skeletal troponin I, troponin T, and beta-tropomyosin that cause distal arthrogryposis all increase contractile function.
15489334 2004 The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
14702039 2004 Complete sequencing and characterization of 21,243 full-length human cDNAs.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
11780052 2001 The DNA sequence and comparative analysis of human chromosome 20.
9560191 1998 Crystal structure of troponin C in complex with troponin I fragment at 2.3-A resolution.
9459007 1997 Assignment of the human fast skeletal muscle troponin C gene (TNNC2) between D20S721 and GCT10F11 on chromosome 20 by somatic cell hybrid analysis.
9016781 1997 Fine mapping of five human skeletal muscle genes: alpha-tropomyosin, beta-tropomyosin, troponin-I slow-twitch, troponin-I fast-twitch, and troponin-C fast.
7869399 1994 Tissue restricted gene expression assayed by direct DNA injection into cardiac and skeletal muscle.
3166492 1988 Differential expression of slow and fast skeletal muscle troponin C. Slow skeletal muscle troponin C is expressed in human fibroblasts.
2373703 1990 Cloning, structural analysis, and expression of the human fast twitch skeletal muscle troponin C gene.
978749 1976 Human skeletal muscle proteins. The primary structure of troponin C.