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Tbio Tumor necrosis factor receptor superfamily member 10C

Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. May protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand.

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL. [provided by RefSeq, Jul 2008]

 Comments

Property Summary

NCBI Gene PubMed Count 63
PubMed Score 407.69
PubTator Score 87.32

Knowledge Summary

Patent

No data available

TINX Plot

  Disease (5)

Disease Target Count Z-score Confidence
Arthritis, Juvenile 126 0.0 0.0
Disease Target Count
Juvenile arthritis 126
Disease Target Count Z-score Confidence
Carcinoma 11493 0.0 0.5
Disease Target Count Z-score Confidence
Shellfish allergy 3 4.39 2.2
Chagas disease 39 3.714 1.9
Cancer 2499 3.655 1.8

Expression

  Differential Expression (11)

Disease log2 FC p
adult high grade glioma -1.200 1.2e-03
axial spondyloarthropathy 1.100 1.5e-02
group 4 medulloblastoma -1.100 8.1e-04
juvenile dermatomyositis -1.251 3.0e-11
lung cancer -2.100 1.0e-02
non-small cell lung cancer -1.438 4.1e-12
osteosarcoma -2.185 2.4e-03
pancreatic cancer 1.300 2.0e-03
pancreatic carcinoma 1.300 2.0e-03
subependymal giant cell astrocytoma 1.136 4.2e-02
tuberculosis 1.900 5.8e-05

Synonym

Accession O14798 O14755 Q08AS6 Q6FH98 Q6UXM5
Symbols LIT
DCR1
TRID
CD263
TRAILR3
TRAIL-R3
DCR1-TNFR

Gene

TNFRSF10C

  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG

 UniProt Keyword (14)

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 GO Function (3)

 GO Component (3)

 GO Process (9)

 Compartment GO Term (14)

 MGI Phenotype (7)

 GWAS Trait (7)

 HCA RNA Cell Line (55)

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Pathway (17)

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Protein-protein Interaction (55)

TTI2   SGPL1   ATP12A   SLC29A2   SLC38A2   FLVCR1   TMEM192   TCAF2   ORC5   PTRH2   SLC26A2   PTGFRN   SCAMP3   SCAMP1   HSDL1   SLC44A5   SLC29A1   FASTKD2   LRRC4B   TMEM186   SLC22A23   STX7   ATP11C   PLPP3   STX12   LAPTM4B   SLC44A1   MTCH2   MYORG   TMEM94   STEAP3   SLC6A6   SLC19A1   SLC41A1   CANT1   LPAR1   SLC47A1   PRAF2   ENDOD1   ALG14   SLC35F2   NCEH1   LGALS1   VAMP3   SLC15A4   SLC26A6   SLC6A8   MTDH   NR2F2   NR2F6   ANO6   TMEM245   ZDHHC18   TMEM175   AGTRAP  

Gene RIF (40)

AA Sequence 

MARIPKTLKFVVVIVAVLLPVLAYSATTARQEEVPQQTVAPQQQRHSFKGEECPAGSHRSEHTGACNPCT      1 - 70
EGVDYTNASNNEPSCFPCTVCKSDQKHKSSCTMTRDTVCQCKEGTFRNENSPEMCRKCSRCPSGEVQVSN     71 - 140
CTSWDDIQCVEEFGANATVETPAAEETMNTSPGTPAPAAEETMNTSPGTPAPAAEETMTTSPGTPAPAAE    141 - 210
ETMTTSPGTPAPAAEETMITSPGTPASSHYLSCTIVGIIVLIVLLIVFV                         211 - 259
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Text Mined References (64)

PMID Year Title