Tbio | Tumor necrosis factor receptor superfamily member 10C |
Receptor for the cytotoxic ligand TRAIL. Lacks a cytoplasmic death domain and hence is not capable of inducing apoptosis. May protect cells against TRAIL mediated apoptosis by competing with TRAIL-R1 and R2 for binding to the ligand.
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL. [provided by RefSeq, Jul 2008]
Comments
Disease | Target Count | Z-score | Confidence |
---|---|---|---|
Arthritis, Juvenile | 126 | 0.0 | 0.0 |
Disease | Target Count |
---|---|
Juvenile arthritis | 126 |
Disease | Target Count | P-value |
---|---|---|
non-small cell lung cancer | 2890 | 4.1e-12 |
juvenile dermatomyositis | 1187 | 3.0e-11 |
tuberculosis | 2010 | 5.8e-05 |
group 4 medulloblastoma | 1855 | 8.1e-04 |
adult high grade glioma | 3801 | 1.2e-03 |
pancreatic cancer | 2398 | 2.0e-03 |
pancreatic carcinoma | 562 | 2.0e-03 |
osteosarcoma | 7950 | 2.4e-03 |
lung cancer | 4740 | 1.0e-02 |
axial spondyloarthropathy | 28 | 1.5e-02 |
subependymal giant cell astrocytoma | 2287 | 4.2e-02 |
Disease | log2 FC | p |
---|---|---|
adult high grade glioma | -1.200 | 1.2e-03 |
axial spondyloarthropathy | 1.100 | 1.5e-02 |
group 4 medulloblastoma | -1.100 | 8.1e-04 |
juvenile dermatomyositis | -1.251 | 3.0e-11 |
lung cancer | -2.100 | 1.0e-02 |
non-small cell lung cancer | -1.438 | 4.1e-12 |
osteosarcoma | -2.185 | 2.4e-03 |
pancreatic cancer | 1.300 | 2.0e-03 |
pancreatic carcinoma | 1.300 | 2.0e-03 |
subependymal giant cell astrocytoma | 1.136 | 4.2e-02 |
tuberculosis | 1.900 | 5.8e-05 |
TTI2
SGPL1
ATP12A
SLC29A2
SLC38A2
FLVCR1
TMEM192
TCAF2
ORC5
PTRH2
SLC26A2
PTGFRN
SCAMP3
SCAMP1
HSDL1
SLC44A5
SLC29A1
FASTKD2
LRRC4B
TMEM186
SLC22A23
STX7
ATP11C
PLPP3
STX12
LAPTM4B
SLC44A1
MTCH2
MYORG
TMEM94
STEAP3
SLC6A6
SLC19A1
SLC41A1
CANT1
LPAR1
SLC47A1
PRAF2
ENDOD1
ALG14
SLC35F2
NCEH1
LGALS1
VAMP3
SLC15A4
SLC26A6
SLC6A8
MTDH
NR2F2
NR2F6
ANO6
TMEM245
ZDHHC18
TMEM175
AGTRAP
MARIPKTLKFVVVIVAVLLPVLAYSATTARQEEVPQQTVAPQQQRHSFKGEECPAGSHRSEHTGACNPCT 1 - 70 EGVDYTNASNNEPSCFPCTVCKSDQKHKSSCTMTRDTVCQCKEGTFRNENSPEMCRKCSRCPSGEVQVSN 71 - 140 CTSWDDIQCVEEFGANATVETPAAEETMNTSPGTPAPAAEETMNTSPGTPAPAAEETMTTSPGTPAPAAE 141 - 210 ETMTTSPGTPAPAAEETMITSPGTPASSHYLSCTIVGIIVLIVLLIVFV 211 - 259 //