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Tdark Tumor necrosis factor alpha-induced protein 8-like protein 3

Acts as a lipid transfer protein. Preferentially captures and shuttles two lipid second messengers, i.e., phosphatidylinositol 4,5- bisphosphate and phosphatidylinositol 3,4,5-trisphosphate and increases their levels in the plasma membrane. Additionally, may also function as a lipid-presenting protein to enhance the activity of the PI3K-AKT and MEK-ERK pathways. May act as a regulator of tumorigenesis through its activation of phospholipid signaling.

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Property Summary

NCBI Gene PubMed Count 5
PubMed Score 4.23
PubTator Score 3.61

Knowledge Summary

Patent

No data available

Expression

Synonym

Accession Q5GJ75 Q6ZWD1 TNF alpha-induced protein 8-like protein 3
Symbols TIPE3

Gene

TNFAIP8L3

  Ortholog (12)

Species Source Disease
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid OMA EggNOG
Inparanoid EggNOG

 UniProt Keyword (9)

 GO Function (2)

 GO Component (3)

 GO Process (8)

 Compartment GO Term (24)

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 GWAS Trait (3)

 HCA RNA Cell Line (56)

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Pathway (4)

PDB (1)

Gene RIF (2)

AA Sequence 

MGKPRQNPSTLVSTLCEAEPKGKLWVNGYAGTQGTRDATLQTRLIPLSFHLQRGKGLAAPLSALSAPRLP      1 - 70
ERPADGRVAVDAQPAARSMDSDSGEQSEGEPVTAAGPDVFSSKSLALQAQKKILSKIASKTVANMLIDDT     71 - 140
SSEIFDELYKVTKEHTHNKKEAHKIMKDLIKVAIKIGILYRNNQFSQEELVIVEKFRKKLNQTAMTIVSF    141 - 210
YEVEYTFDRNVLSNLLHECKDLVHELVQRHLTPRTHGRINHVFNHFADVEFLSTLYSLDGDCRPNLKRIC    211 - 280
EGINKLLDEKVL                                                              281 - 292
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Text Mined References (7)

PMID Year Title