Property Summary

NCBI Gene PubMed Count 20
PubMed Score 55.41
PubTator Score 28.78

Knowledge Summary

Patent

No data available

Expression

  Differential Expression (20)

Disease log2 FC p
psoriasis -1.800 1.4e-04
osteosarcoma -3.113 3.5e-07
posterior fossa group A ependymoma 1.800 6.0e-05
cystic fibrosis 1.412 9.9e-04
glioblastoma 1.400 1.5e-03
adrenocortical carcinoma -1.214 5.2e-03
pancreatic ductal adenocarcinoma liver m... 1.631 4.7e-02
intraductal papillary-mucinous neoplasm ... 2.100 5.6e-03
X-linked cerebral adrenoleukodystrophy -1.100 4.7e-02
lung cancer -2.600 5.6e-06
active ulcerative colitis 1.787 1.2e-02
pancreatic cancer 1.500 3.3e-03
interstitial cystitis -1.100 4.7e-03
subependymal giant cell astrocytoma 1.342 2.7e-02
lung carcinoma -1.400 6.4e-22
gastric carcinoma 1.700 2.1e-02
mucosa-associated lymphoid tissue lympho... 1.438 4.6e-02
ovarian cancer 1.400 1.8e-07
Gaucher disease type 1 1.300 4.9e-03
head and neck cancer 1.400 2.4e-03

Synonym

Accession Q03169 Q86VI0 TNF alpha-induced protein 2
Symbols B94
EXOC3L3

Gene

PANTHER Protein Class (1)

  Ortholog (1)

Species Source Disease
Chimp OMA EggNOG Inparanoid

Gene RIF (15)

PMID Text
26347487 data suggest that TNFAIP2 is a novel inhibitor of NF-kappa-B that acts as an autoinhibitor of the TNFalpha response during septic shock.
26189798 findings collectively suggest that TNFAIP2 is a direct KLF5 target gene, and both KLF5 and TNFAIP2 promote breast cancer cell proliferation, migration and invasion through Rac1 and Cdc42
25383966 A functional TNFAIP2 3'-UTR rs8126 genetic polymorphism contributes to risk of esophageal squamous cell carcinoma.
23975427 the regulation of TNFAIP2 and its role in promoting NPC tumor progression
23724109 The TNFAIP2 miRNA binding site rs8126 T>C single nucleotide polymorphism may be a marker for susceptibility to gastric cancer.
21934093 A functional variant at the miR-184 binding site in TNFAIP2 is associated with squamous cell carcinoma of the head and neck.
21921781 TNFAIP2 may serve as a useful new marker of dendritic and histiocytic sarcomas.
21555518 TNFAIP2 is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells.
21057457 TNFAIP2 is a cell migration-promoting protein and its expression predicts distant metastasis. Our data suggest that TNFAIP2 may serve as an independent prognostic indicator for nasopharyngeal carcinoma.
20628624 Meta-analysis of gene-disease association. (HuGE Navigator)
20628086 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
20237496 Observational study of gene-disease association. (HuGE Navigator)
20157331 Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator)
19913121 Observational study of gene-disease association. (HuGE Navigator)
19339270 Observational study of gene-disease association. (HuGE Navigator)

AA Sequence

MSEASSEDLVPPLEAGAAPYREEEEAAKKKKEKKKKSKGLANVFCVFTKGKKKKGQPSSAEPEDAAGSRQ      1 - 70
GLDGPPPTVEELKAALERGQLEAARPLLALERELAAAAAAGGVSEEELVRRQSKVEALYELLRDQVLGVL     71 - 140
RRPLEAPPERLRQALAVVAEQEREDRQAAAAGPGTSGLAATRPRRWLQLWRRGVAEAAEERMGQRPAAGA    141 - 210
EVPESVFLHLGRTMKEDLEAVVERLKPLFPAEFGVVAAYAESYHQHFAAHLAAVAQFELCERDTYMLLLW    211 - 280
VQNLYPNDIINSPKLVGELQGMGLGSLLPPRQIRLLEATFLSSEAANVRELMDRALELEARRWAEDVPPQ    281 - 350
RLDGHCHSELAIDIIQITSQAQAKAESITLDLGSQIKRVLLVELPAFLRSYQRAFNEFLERGKQLTNYRA    351 - 420
NVIANINNCLSFRMSMEQNWQVPQDTLSLLLGPLGELKSHGFDTLLQNLHEDLKPLFKRFTHTRWAAPVE    421 - 490
TLENIIATVDTRLPEFSELQGCFREELMEALHLHLVKEYIIQLSKGRLVLKTAEQQQQLAGYILANADTI    491 - 560
QHFCTQHGSPATWLQPALPTLAEIIRLQDPSAIKIEVATYATCYPDFSKGHLSAILAIKGNLSNSEVKRI    561 - 630
RSILDVSMGAQEPSRPLFSLIKVG                                                  631 - 654
//

Text Mined References (21)

PMID Year Title
26347487 2016 TNFAIP2 Inhibits Early TNF?-Induced NF-x03BA;B Signaling and Decreases Survival in Septic Shock Patients.
26189798 2016 KLF5 promotes breast cancer proliferation, migration and invasion in part by upregulating the transcription of TNFAIP2.
25383966 2014 A functional TNFAIP2 3'-UTR rs8126 genetic polymorphism contributes to risk of esophageal squamous cell carcinoma.
23975427 2014 NF-?B-mediated transcriptional upregulation of TNFAIP2 by the Epstein-Barr virus oncoprotein, LMP1, promotes cell motility in nasopharyngeal carcinoma.
23724109 2013 The miR-184 binding-site rs8126 T>C polymorphism in TNFAIP2 is associated with risk of gastric cancer.
21934093 2011 A functional variant at the miR-184 binding site in TNFAIP2 and risk of squamous cell carcinoma of the head and neck.
21921781 2011 Aberrant expression of the dendritic cell marker TNFAIP2 by the malignant cells of Hodgkin lymphoma and primary mediastinal large B-cell lymphoma distinguishes these tumor types from morphologically and phenotypically similar lymphomas.
21555518 2011 The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle.
21399635 2011 Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis.
21057457 2011 A novel role for TNFAIP2: its correlation with invasion and metastasis in nasopharyngeal carcinoma.
20628624 2010 Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility "hot-spot".
20628086 2010 Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.
20237496 2010 New genetic associations detected in a host response study to hepatitis B vaccine.
20157331 2010 SNPs in genes coding for ROS metabolism and signalling in association with docetaxel clearance.
19913121 2009 Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.
19339270 2009 Genetic associations of 115 polymorphisms with cancers of the upper aerodigestive tract across 10 European countries: the ARCAGE project.
12508121 2003 The DNA sequence and analysis of human chromosome 14.
12477932 2002 Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.
10766166 2000 Identification of B94 (TNFAIP2) as a potential retinoic acid target gene in acute promyelocytic leukemia.
8106408 1994 B94, a primary response gene inducible by tumor necrosis factor-alpha, is expressed in developing hematopoietic tissues and the sperm acrosome.
1374453 1992 Cloning of a novel tumor necrosis factor-alpha-inducible primary response gene that is differentially expressed in development and capillary tube-like formation in vitro.