TMUB1
Transmembrane and ubiquitin-like domain-containing protein 1
Protein Summary
Involved in sterol-regulated ubiquitination and degradation of HMG-CoA reductase HMGCR (PubMed:21343306). Involved in positive regulation of AMPA-selective glutamate receptor GRIA2 recycling to the cell surface (By similarity). Acts as negative regulator of hepatocyte growth during regeneration (By similarity). iHOPS: May contribute to the regulation of translation during cell-cycle progression. May contribute to the regulation of cell proliferation (By similarity). May be involved in centrosome assembly. Modulates stabilization and nucleolar localization of tumor suppressor CDKN2A and enhances association between CDKN2A and NPM1 (By similarity).
- ENST00000297533
- ENSP00000297533
- ENSG00000164897
- ENST00000392818
- ENSP00000376565
- ENST00000462940
- ENSP00000417519
- ENST00000476627
- ENSP00000419214
- ENST00000482202
- ENSP00000418709
- C7orf21
- DULP
- HOPS
- DULP
- SB144
- C7orf21
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
cell type or tissue | 0.81 | ||
tissue sample | 0.65 | ||
cell line | 0.57 | ||
tissue | 0.55 | ||
transcription factor binding site profile | 0.51 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 12.51 (req: < 5)
Gene RIFs: 7 (req: <= 3)
Antibodies: 100 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 12.51 (req: >= 5)
Gene RIFs: 7 (req: > 3)
Antibodies: 100 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Term: 1
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0