| Tbio | Tropomodulin-3 |
Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity).
Comments
| Disease | Target Count | P-value |
|---|---|---|
| juvenile dermatomyositis | 1187 | 2.3e-09 |
| ependymoma | 4679 | 8.6e-09 |
| osteosarcoma | 7950 | 1.0e-07 |
| ovarian cancer | 8520 | 1.0e-06 |
| atypical teratoid / rhabdoid tumor | 5112 | 1.6e-05 |
| medulloblastoma, large-cell | 6241 | 1.7e-05 |
| psoriasis | 6694 | 2.6e-05 |
| adult high grade glioma | 3801 | 1.5e-03 |
| glioblastoma | 5792 | 2.6e-03 |
| group 4 medulloblastoma | 1855 | 2.9e-03 |
| primary pancreatic ductal adenocarcinoma | 1109 | 1.2e-02 |
| intraductal papillary-mucinous neoplasm (IPMN) | 3291 | 2.0e-02 |
| aldosterone-producing adenoma | 665 | 2.4e-02 |
| spina bifida | 1074 | 4.0e-02 |
| Disease | Target Count | Z-score | Confidence |
|---|---|---|---|
| Amyotrophic lateral sclerosis type 5 | 13 | 3.92 | 2.0 |
| Gynecomastia | 64 | 3.476 | 1.7 |
| Estrogen excess | 4 | 3.23 | 1.6 |
| Disease | log2 FC | p |
|---|---|---|
| adult high grade glioma | 1.300 | 1.5e-03 |
| aldosterone-producing adenoma | -1.149 | 2.4e-02 |
| atypical teratoid / rhabdoid tumor | 1.500 | 1.6e-05 |
| ependymoma | 1.700 | 8.6e-09 |
| glioblastoma | 1.600 | 2.6e-03 |
| group 4 medulloblastoma | 1.200 | 2.9e-03 |
| intraductal papillary-mucinous neoplasm ... | 1.600 | 2.0e-02 |
| juvenile dermatomyositis | 1.079 | 2.3e-09 |
| medulloblastoma, large-cell | 1.500 | 1.7e-05 |
| osteosarcoma | -2.223 | 1.0e-07 |
| ovarian cancer | 1.200 | 1.0e-06 |
| primary pancreatic ductal adenocarcinoma | 1.291 | 1.2e-02 |
| psoriasis | 1.400 | 2.6e-05 |
| spina bifida | -2.216 | 4.0e-02 |
| Species | Source | Disease |
|---|---|---|
| Inparanoid OMA | ||
| Inparanoid OMA | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA | ||
| Inparanoid OMA | ||
| Inparanoid OMA | ||
| Inparanoid OMA | ||
| Inparanoid OMA | ||
| Inparanoid OMA | ||
| Inparanoid OMA EggNOG | ||
| Inparanoid OMA EggNOG | ||
| OMA EggNOG |
MALPFRKDLEKYKDLDEDELLGNLSETELKQLETVLDDLDPENALLPAGFRQKNQTSKSTTGPFDREHLL 1 - 70 SYLEKEALEHKDREDYVPYTGEKKGKIFIPKQKPVQTFTEEKVSLDPELEEALTSASDTELCDLAAILGM 71 - 140 HNLITNTKFCNIMGSSNGVDQEHFSNVVKGEKILPVFDEPPNPTNVEESLKRTKENDAHLVEVNLNNIKN 141 - 210 IPIPTLKDFAKALETNTHVKCFSLAATRSNDPVATAFAEMLKVNKTLKSLNVESNFITGVGILALIDALR 211 - 280 DNETLAELKIDNQRQQLGTAVELEMAKMLEENTNILKFGYQFTQQGPRTRAANAITKNNDLVRKRRVEGD 281 - 350 HQ 351 - 352 //
